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Lignan compound and preparation method and application thereof

A technology of lignans and compounds, applied in the field of medicine, can solve problems such as unreported anti-tumor activity

Active Publication Date: 2020-04-07
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the anti-neuroinflammatory and anti-tumor activities of lignans in tung tree

Method used

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  • Lignan compound and preparation method and application thereof
  • Lignan compound and preparation method and application thereof
  • Lignan compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) 1 kg of tung tree seed shells were extracted 3 times with 75% ethanol, each time for 2 hours (each dosage: 12 L), and the extract was recovered under reduced pressure to obtain a crude extract;

[0029] (2) The ethanol extract obtained in step (1) is dissolved in water, and then extracted with sherwood oil, ethyl acetate, and n-butanol. The volume ratio of the extract and the extraction solvent is 1:1, and each solvent is extracted 5 times to obtain Extracts of different polar parts;

[0030] (3) The ethyl acetate extract obtained in step (2) was separated by silica gel column chromatography, and eluted successively with petroleum ether: ethyl acetate 100:1, 100:2, 100:4, 100:6, 100:10;

[0031] (4) Petroleum ether obtained in the above step (3): Ethyl acetate 100:1~100:4 fraction is separated by ODS chromatography, and methanol / water 10:90, 20:80, 40:60, 60:40 For mobile phase gradient elution;

[0032] (5) The methanol:water (2:8~8:2) fraction obtained in the ab...

Embodiment 2

[0055] (1) 1 kg of tung tree seed shells were extracted 3 times with 85% ethanol, each time for 2 hours (each dosage: 15 L), and the extract was recovered under reduced pressure to obtain a crude extract;

[0056] (2) The ethanol extract obtained in step (1) is dissolved in water, and then extracted with sherwood oil, ethyl acetate, and n-butanol. The volume ratio of the extract to the extraction solvent is 1:1, and each solvent is extracted 4 times to obtain Extracts of different polar parts;

[0057] (3) The ethyl acetate extract obtained in step (2) was separated by silica gel column chromatography, and eluted successively with petroleum ether: acetone 100:2, 100:4, 100:6, 100:10;

[0058] (4) Petroleum ether obtained in the above step (3): Acetone 100:2~100:4 Fractions are separated by ODS chromatography, using methanol / water 10:90, 20:80, 40:60, 60:40 as the flow Phase gradient elution;

[0059] (5) The methanol:water (2:8~8:2) fraction obtained in the above step (4) wa...

Embodiment 3

[0063] (1) 1 kg of tung tree seed shells were extracted 3 times with 75% ethanol, each time for 2 hours (each dosage: 12 L), and the extract was recovered under reduced pressure to obtain a crude extract;

[0064] (2) The ethanol extract obtained in step (1) is dissolved in water, and then extracted with sherwood oil, ethyl acetate, and n-butanol. The volume ratio of the extract and the extraction solvent is 1:1, and each solvent is extracted 5 times to obtain Extracts of different polar parts;

[0065] (3) The ethyl acetate extract obtained in step (2) was separated by silica gel column chromatography, and eluted successively with dichloromethane:methanol 100:1, 100:2, 100:4, 100:6, and 100:10;

[0066] (4) Dichloromethane obtained in the above step (3): Methanol 100:1~100:4 fraction is separated by ODS chromatography, with acetonitrile / water 10:90, 20:80, 40:60, 60:40 as Mobile phase gradient elution;

[0067] (5) The acetonitrile:water (2:8~8:2) fraction obtained in the a...

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Abstract

The invention belongs to the technical field of medicines, and relates to a lignan compound and a preparation method and medical application thereof, in particular to a diploid lignan and monoploid lignan compound and a preparation method thereof and application in the field of preparation of drugs for preventing or treating neurodegenerative diseases. The structure of the compound is shown as described in the specifications, and R1, R2, R3 and R4 are hydroxymethyl or 3, 4-dihydroxyphenyl.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to lignan compounds and their preparation methods and applications, in particular to diplo-lignans and haploid lignans in tung tree seed shells and their preparation methods and applications. Background technique [0002] Tung tree (Vernicia fordii), also known as three-year tung tree, tung tree, tung oil tree, tung tree, and light tung tree, is a plant of the genus Tung tree in Euphorbiaceae. Tung Tung is cold in nature, sweet in taste, slightly pungent, and poisonous. Its roots, leaves and seeds can be used as medicine. There are 3 species in the world, distributed in eastern Asia, and 2 species in my country, mainly produced in Hunan, Sichuan, Guizhou and other provinces. [0003] Tung tung was first recorded in the Dictionary of Traditional Chinese Medicine published by Shanghai Science and Technology Press in 1986. Its leaves, roots and seeds all have anti-inflammatory effects...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04C07D319/20A61P25/00A61P25/28A61K31/357
CPCA61P25/00A61P25/28C07B2200/07C07D319/20C07D493/04
Inventor 李宁陈刚周地
Owner SHENYANG PHARMA UNIVERSITY