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Circulating circular RNA markers and applications for the diagnosis of invasive papillary thyroid carcinoma

A technology of papillary cancer and markers, applied in the field of biomedicine, can solve the problem of few studies on the diagnostic effect of circulating circRNAs, and achieve the effect of reducing the waste of medical resources, reducing medical costs, and improving patient survival

Active Publication Date: 2022-06-07
JIANGSU CANCER HOSPITAL
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  • Claims
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Problems solved by technology

[0006] To date, although biomarkers for PTC have been extensively studied, few studies have focused on the diagnostic efficacy of circulating circRNAs in aggressive PTC

Method used

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  • Circulating circular RNA markers and applications for the diagnosis of invasive papillary thyroid carcinoma
  • Circulating circular RNA markers and applications for the diagnosis of invasive papillary thyroid carcinoma
  • Circulating circular RNA markers and applications for the diagnosis of invasive papillary thyroid carcinoma

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Embodiment 1

[0040] 1. Experimental Design

[0041] A total of 120 invasive PTC patients and 120 non-invasive PTC patients from the head and neck surgery of Nanjing Medical University Affiliated Cancer Hospital from 2014 to 2018 were included in the present invention. The study was conducted in accordance with the World Medical Association Declaration of Helsinki (5th revision, October 2000) and was approved by the Ethics Committee of the Cancer Hospital Affiliated to Nanjing Medical University. Written informed consent was provided by all study participants. These patients were all newly diagnosed patients. Postoperative pathology confirmed papillary thyroid carcinoma. Each tissue specimen was stored in liquid nitrogen, and blood samples were stored in a -80 °C freezer. Each blood sample was placed in an EDTA-anticoagulant tube, centrifuged at 800g at room temperature for 10 minutes to separate plasma, followed by high-speed centrifugation at 10,000g at room temperature for 15 minutes ...

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Abstract

The invention belongs to the technical field of biological detection, and specifically discloses a circulating circular RNA marker for diagnosing invasive papillary thyroid carcinoma and its application. The biomarker for diagnosing invasive papillary thyroid carcinoma is circulating circular RNA, The circulating circular RNAs are circ_0058090 and circ_0014188. The biomarker of the invention has high sensitivity and specificity, can be effectively used in the diagnosis of invasive PTC, and can significantly improve the survival of patients.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to a biomarker for diagnosing invasive papillary thyroid carcinoma and its application. Background technique [0002] Thyroid cancer is one of the common endocrine system malignancies, and its incidence is increasing year by year. There are over 53,990 new cases every year. Its main histological type is papillary carcinoma, accounting for more than 75% of all cases. Although most patients with papillary thyroid carcinoma (PTC) have a good prognosis with a 5-year survival rate as high as 95%, there are still 13% to 15% of patients with extrathyroidal invasive features that easily invade the larynx, trachea, esophagus, and neck. Important organ structures such as large blood vessels are prone to regional lymph nodes and distant metastasis. This aggressive feature leads to a higher recurrence rate and mortality rate of the disease. Severe local uncontrollable external invasion is ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/178C12Q2600/158C12Q2600/118
Inventor 张园陈云姚瑶陈心源闫忠义冯东举练森林程帅徐昕媛仲达刘苏钱亦淳陈伟
Owner JIANGSU CANCER HOSPITAL
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