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Antibacterial antifungal composition

A technology of composition and carbon number, applied in detergent compositions, antibacterial drugs, non-surface-active detergent compositions, etc., to achieve the effects of high antibacterial properties, high safety, and excellent moisturizing properties

Pending Publication Date: 2020-04-21
ADEKA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Parabens have been used as such antibacterial and antifungal agents. However, in recent years, the number of people allergic to parabens has increased. Antibacterial and antifungal agent with high safety

Method used

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  • Antibacterial antifungal composition
  • Antibacterial antifungal composition
  • Antibacterial antifungal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～2、 comparative example 1～11

[0076]

[0077] According to the mass ratio of the components shown in Table 1 and Table 2 (the sum of the mass ratios of the components in each example is 1.0), the antibacterial and antifungal compositions made of three components of the present invention are prepared respectively, and the antibacterial and antifungal compositions as comparative examples An antibacterial and antifungal composition composed of only two components, only one component, or other three components.

[0078] [Table 1]

[0079] Table 1

[0080]

[0081] [Table 2]

[0082] Table 2

[0083]

[0084]

[0085] ingredient (A)

[0086] A-1: 1,2-octanediol (caprylyl glycol)

[0087] ingredient (B)

[0088] B-1: 2-Ethylhexylglycerin Ether (Ethylhexylglycerin)

[0089] ingredient (C)

[0090] C-1: Phenylethyl alcohol

[0091] C-2: Benzyl alcohol

[0092] Component (D) (comparison component)

[0093] D-1: sodium benzoate

[0094] D-2: Phenoxyethanol

[0095]

[0096]

[0097] E. coli...

Embodiment 3～6、 comparative example 12

[0117]

[0118] The wet tissue drug solutions of Examples 3 to 6 and Comparative Example 12 having the compositions shown below were prepared. It should be noted that the figures in Table 5 are the mass % of the drug solution relative to the wet tissue.

[0119]

[0120]

[0121] [table 5]

[0122] table 5

[0123] Example 3 Example 4 Example 5 Example 6 Comparative Example 12 A-1 0.20 0.25 0.30 0.30 0.30 B-1 0.20 0.25 0.30 0.30 0.30 C-1 0.20 0.25 0.30 C-2 0.30

[0124]

[0125] Add 20 g of the wet tissue drug solution produced in Examples 3 to 6 and Comparative Example 12, and 0.20 mL of live bacteria to a sterilized glass bottle with a cap of 30 mL capacity so that the concentration is 1.0×10 8 cfu / mL level of bacteria liquid, mixed evenly. The day when the glass bottle was stored in a constant temperature tank at 25°C was regarded as day 0, and samples were taken after 2 days and 7 days, and the co...

Embodiment 7～13、 comparative example 13～14

[0140]

[0141] According to the mass ratio of the components shown in Table 7 (the sum of the mass ratios of the components in each example is 1.0), the antibacterial and antifungal compositions composed of three components of the present invention, and the antibacterial and antifungal compositions composed of only two An antibacterial and antifungal composition composed of several ingredients. For each antibacterial and antifungal composition, the minimum inhibitory concentration to fungi was measured by the same method as the test method of Example 1, and the FIC (Fractional Inhibitory Concentration: fractional inhibitory concentration) index was calculated according to the following formula. The FIC index is an index for evaluating the synergistic effect of antibacterial properties on a composition composed of two or more components. If the FIC index is less than 1, it indicates that there is a synergistic effect, and when it is greater than 1, it indicates that there is ...

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PUM

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Abstract

An antibacterial antifungal composition containing: (A) at least one 1,2-alkanediol having a linear alkyl group of 6 to 8 carbons; (B) at least one monoalkyl glyceryl ether having a linear alkyl groupof 6 to 8 carbons, a branched alkyl group of 6 to 8 carbons, or a cycloalkyl group of 6 to 8 carbons; and (C) at least one aromatic alcohol represented by general formula (1) (in the formula, n represents a natural number from 1 to 4).

Description

technical field [0001] The invention relates to an antibacterial and antimildew composition with high safety to human body and high antibacterial and antifungal properties. Background technique [0002] In cosmetics, cleaning agents, etc., antibacterial agents and antifungal agents are generally used for the purpose of preservation and the like. Parabens have been used as such antibacterial and antifungal agents. However, in recent years, the number of people allergic to parabens has increased. Antibacterial and antifungal agent with high safety. [0003] Therefore, glycol compounds such as alkanediols and alkyl glyceryl ethers, and mixtures thereof are known as antibacterial agents. Patent Document 1 discloses an antibacterial agent composed of a diol compound having a residue obtained by removing one hydroxyl group from a trihydric or higher alcohol. Patent Document 2 discloses an external composition containing 1,2-pentanediol and 2-phenoxyethanol. In Patent Document ...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61Q19/10C11D7/26
CPCA61K8/34A61Q19/10C11D7/26A61Q17/005A61K8/345A61K2800/5922A61Q19/00A61P31/04C11D3/48C11D17/049C11D7/261C11D7/263A01N31/04
Inventor 津岛康宏铃木裕之八泽麻贵子山下小丹
Owner ADEKA CORP
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