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Preparation method of anti-respiratory-system-virosis fiber

A technology for viral diseases and respiratory system, applied in the field of preparation of functional fibers, can solve the problems of cross infection, accelerated spread of germs, high infection activity of germs, etc., and achieves the effects of good stability, easy control of reaction, and broad prospects for promotion.

Inactive Publication Date: 2020-04-28
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, N95, N99 protective masks and microfiber protective clothing materials (Chinese invention patents: CN1539531A, CN106102863A, CN104757710A) commonly used in the medical and health field can effectively intercept and block the above-mentioned bacteria, but the bacteria intercepted on the surface are still It has high infectious activity, and it is very easy to cause cross-infection and accelerate the spread of germs when it contacts with healthy people and removes protective equipment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of anti-respiratory viral disease fiber, the fiber uses polyethylene terephthalate (PET) as the base material, uses exogenous lung surfactant, modifies long-chain phospholipid molecules on the surface, and further absorbs phosphoric acid Glycerides, acidic phospholipids and pulmonary surfactant antiviral drugs with specific protein composition, the exogenous pulmonary surfactants are phospholipids, triglycerides, cholesterol, free fatty acids and proteins, prepared according to the following steps:

[0022] (1) Soak PET in concentrated sodium hydroxide, stir for 24 hours, wash and dry, and then place it in a concentration of K 2 Cr 2 o 7 :H 2 SO 4 :H 2 O = 1:20:2 (w / v / w) chromic acid solution, sonicate at 60°C for 15 minutes, then wash with deionized water until the washing solution is neutral, and dry at room temperature;

[0023] (2) Disperse the PET obtained in step (1) in 0.1 mol / L sodium hydroxide aqueous solution, add 0.1 mol EDC and 0.1 mol NHS, stir ...

Embodiment 2

[0026] A kind of anti-respiratory virus disease fiber, similar to embodiment 1, is prepared according to the following steps:

[0027] (1) Soak PET in concentrated sodium hydroxide, stir for 24 hours, wash and dry, and then place it in a concentration of K 2 Cr 2 o 7 :H 2 SO 4 :H 2 O = 1:20:2 (w / v / w) chromic acid solution, sonicate at 60°C for 15 minutes, then wash with deionized water until the washing solution is neutral, and dry at room temperature;

[0028] (2) Disperse the PET obtained in step (1) in 0.1 mol / L sodium bicarbonate aqueous solution, add 0.3 mol EDC and 0.3 mol NHS, stir at room temperature for 3 hours, add 0.1 mol dilauroylphosphatidylcholine, and After stirring for 3 hours, wash and dry with water to obtain a surface-treated PET material;

[0029] (3) Disperse the surface-treated PET material in a mixed solvent with a volume ratio of 1:1 toluene and ethanol to form a suspension solution, add 60% dilauroylphosphatidylcholine, 3% triglyceride, 1 % chol...

Embodiment 3

[0032] A kind of anti-respiratory virus disease fiber, similar to embodiment 1, is prepared according to the following steps:

[0033] (1) Soak PET in concentrated sodium hydroxide, stir for 24 hours, wash and dry, and then place it in a concentration of K 2 Cr 2 o 7 :H 2 SO 4 :H 2 O = 1:20:2 (w / v / w) chromic acid solution, sonicate at 60°C for 15 minutes, then wash with deionized water until the washing solution is neutral, and dry at room temperature;

[0034](2) Disperse the PET obtained in step (1) in 0.1 mol / L ammonia solution, add 0.5 mol of EDC and 0.5 mol of NHS, stir at room temperature for 3 hours, then add 0.3 mol of 1-stearoyl-2-palmitoyl phospholipid Acylcholine, stirred at room temperature for 3 hours, washed with water and dried to obtain the surface-treated PET material;

[0035] (3) Disperse the surface-treated PET material in a mixed solvent of toluene and ethanol (1:1 by volume) to form a suspension solution, and add 90% by weight of 1-stearoyl-2-palmit...

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Abstract

The invention provides a preparation method of an anti-respiratory-system-virosis fiber. According to the fiber, polyethylene terephthalate (PET) is used as a substrate, exogenous pulmonary surfactantis used, by surface modifying long-chain phospholipid molecules, and glycerol phosphate, acidic phospholipids and a pulmonary surfactant antiviral drug composed of specific proteins are further adsorbed. The protection and treatment of respiratory system virosis are realized. The fiber can be used to prepare products such as protective masks, wherein exogenous pulmonary surfactant are loaded on the surface of the fiber by means of adsorption and can enter a body through breathing to play an antiviral effect. The preparation method is simple in preparation procss, the reaction is easy to control, the stability is good, and the preparation method can be industrialized and has a broad promotion prospect.

Description

technical field [0001] The invention relates to the field of preparation of functional fibers, in particular to a preparation method of anti-respiratory virus disease fibers. Background technique [0002] Haze not only brings inconvenience to people's lives, but also brings great harm to people's health. Studies have shown that harmful substances in smog can damage the nervous system, cardiovascular system, respiratory system, and endocrine system. The reason is that the aerosol particles in the smog, such as mineral particles, sea salt, sulfate, nitrate, organic aerosol particles, fuel and vehicle exhaust, etc., absorb a large number of toxic components, bacteria and viruses, and can directly enter the environment with breathing. And adhere to the human respiratory tract and alveoli. [0003] Therefore, products with antibacterial and antivirus protection are widely concerned. Because the main infection route of germs is air droplets and body fluid contact transmission, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M13/463D06M13/224D06M13/144D06M13/188D06M15/15D06M11/38D06M11/48D06M11/55D06M101/32
CPCD06M13/463D06M13/2243D06M13/144D06M13/188D06M15/15D06M11/38D06M11/48D06M11/55D06M16/00D06M2101/32
Inventor 崔大祥朱君刘睿朱竞尧金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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