A kind of antibody-conjugated drug against claudin 6 and its application

Abstract

The invention discloses an antibody-conjugated drug against claudin 6 and its application. The invention relates to an antigen sequence for preparing claudin 6 (CLDN6) antibody, its corresponding nucleotide sequence and a method for expressing the nucleoside Genetic engineering carrier, engineering bacteria or cell line of acid sequence; animal immunization through the antigenic polypeptide can produce highly specific claudin 6 antibody; further prepare hybridoma cells by immunizing animal cells to obtain corresponding monoclonal antibodies; Combining the anti-claudin 6 antibody with a linking structure and a drug can form an antibody-conjugated drug; the antibody-coupled drug can carry the drug to the tumor expressing positive claudin 6 according to the targeting effect of claudin 6 cells, so as to achieve the effect of specifically killing tumor cells, which is of great significance to the treatment of tumors.

Description

technical field

[0001] The invention belongs to the field of biomedicine, relates to an antigen and its corresponding antibody application, in particular to an antibody-coupled drug against claudin 6 and its application. Background technique

[0002] In the 20th century, primary liver cancer has risen to become the second cancer killer in my country, and more than 1 million patients die from liver cancer every year in the world, and the incidence of liver cancer in my country accounts for 40% of the world's total. The treatment of liver cancer is mainly based on surgery, but clinically 90% of liver cancer patients have lost the chance of surgery when they are diagnosed with liver cancer. Moreover, the recurrence rate within 5 years after hepatectomy is as high as 80%, and the long-term survival rate is still not high. Examples of other liver cancer treatments include tissue transplantation, systemic chemotherapy, radiation therapy, and electrocautery. However, these method...

Images