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Method of treatment

A method of treatment, subject's technology, applied in the field of therapy, capable of solving problems affecting ghrelin levels, etc.

Pending Publication Date: 2020-05-08
泰德尔塔有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art does not teach that consumption of exogenous ketones can affect ghrelin levels

Method used

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Examples

Experimental program
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Embodiment

[0193] The invention is described by reference to the following non-limiting examples.

[0194] Study design and participants:

[0195] A randomized, single-blind, crossover study examined the effects of isocaloric ketoester (KE) and dextrose beverages on hunger in healthy normal-weight participants (n = 15) ( Figure 1A ). An external Research Ethics Committee (14 / LO / 0288) approved the study, which was conducted at the University of Oxford in accordance with the Declaration of Helsinki. Participants were healthy, aged 21-42 years, and had no history of major illnesses (anthropometric characteristics in Table 1). Participants provided written informed consent prior to enrollment. The order of drinks is randomized before starting.

[0196] Table 1. Physical Characteristics of Subjects (n=15)

[0197]

[0198] Access protocol:

[0199] Participants should abstain from alcohol and caffeine 24 hours before each visit and eat the same dinner at the same time before each vi...

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PUM

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Abstract

The present invention provides a method of suppressing hunger by lowering plasma ghrelin levels comprising administration of a compound to a human or animal body, wherein the compound is selected from: (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer of (R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof. The invention also provides a method of administering such a compound in a dosage effective to reduce hunger in order that a cosmetically beneficial loss or maintenance of body weight occurs, wherein in the method, plasma ghrelin levels are lowered. The aforementioned compound is also provided for use in a method of treatment of the human or animal body wherein the compound is administered and hunger is suppressed by lowering of plasma ghrelin levels. The compound is particularly useful for subjects having conditions associated with overeating, such as overweight, obese, severely obese patients or diabetic patients.

Description

[0001] field of invention [0002] The present invention relates to methods and compounds for suppressing hunger in a subject by modulating ghrelin levels, and to the treatment of disorders such as obesity. The invention also relates to prophylactic treatment of subjects to avoid or reduce the risk of developing conditions associated with overeating, such as obesity and diabetes. [0003] Background of the invention [0004] Overeating can lead to excess weight. In some cases, overeating can lead to obesity, which in turn has been linked to conditions such as prediabetes, diabetes, metabolic syndrome, high blood pressure, heart disease, heart failure and stroke. Public health can be improved by reducing excess body weight to normal levels in subjects with excess body weight, regardless of whether they are healthy or suffering from diseases associated with excess body weight. [0005] In cases where a subject is not overweight in such an amount as to endanger their health, bei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/191A61K8/36A61K8/362A61K8/37A61K31/215A61K31/70A61P3/00A61P3/04A61P3/10
CPCA61K8/37A61K31/191A61K31/215A61K31/70A61K8/365A61Q19/06A61K8/85A61K2800/92A61P3/04A23L33/30A61P3/10A61K31/22A61K45/06A61K9/0095
Inventor K·克拉克B·斯塔布斯
Owner 泰德尔塔有限公司
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