Preparation method and application of tricyclohexyltin quinoline-6-carboxylate complex
A technology based on hexyltinquinoline and tricyclohexyl, applied in tin organic compounds, pharmaceutical formulations, organic chemical methods, etc., can solve problems such as application limitations and strong toxicity, and achieve simple preparation methods, low cost, and high anticancer activity Effect
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Embodiment 1
[0030] Preparation of tricyclohexyltinquinoline-6-carboxylate complex:
[0031] Add 0.3857 g (1 mmol) of tricyclohexyl tin hydroxide, 0.1735 g (1 mmol) of quinoline-6-carboxylic acid, and 10 mL of anhydrous methanol as a solvent to the microwave reaction tank in sequence. The microwave reaction was carried out at 800 W and 100 °C for 60 min. After the reaction is completed, it is naturally cooled, filtered, and the solvent is naturally volatilized and crystallized at room temperature to obtain a white crystal, which is a tricyclohexyltinquinoline-6-carboxylate complex. Yield: 62%, melting point: 94-96 °C.
[0032] Elemental Analysis (C 28 H 39 NO 2 Sn): Theoretical: C, 62.24; H, 7.28; N, 2.59. Found: C, 62.22; H, 7.25; N, 2.56.
[0033] IR(KBr, v / cm -1 ): 2920.23 (s), 2846.93 (s), 2362.80 (m), 1602.85 (s), 1498.69 (w), 1446.61 (m), 1365.60 (s), 1313.52 (m), 1172.72 (w), 993.34 (w) ), 906.54 (w), 844.82 (w), 798.53 (s), 640.37 (w), 607.58 (w), 478.35 (w), 416.62 (m).
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Embodiment 2
[0038] Preparation of tricyclohexyl tin quinoline-6-carboxylate complex:
[0039] Add 0.3846 g (1 mmol) of tricyclohexyltin hydroxide, 0.1823 g (1.05 mmol) of quinoline-6-carboxylic acid, and 15 mL of anhydrous methanol into the microwave reaction tank in sequence. Microwave reaction was performed at 800 W at 100 °C for 60 min. After the reaction, cool naturally, filter, and the solvent volatilizes naturally at room temperature to crystallize to obtain white crystals, which are tricyclohexyltinquinoline-6-carboxylate complexes. Yield: 63%, melting point: 94-96 °C.
[0040] Elemental analysis (C 28 h 39 NO 2 Sn): theoretical values: C, 62.24; H, 7.28; N, 2.59. Found: C, 62.22; H, 7.25; N, 2.56.
[0041] IR(KBr, v / cm -1 ): 2920.23 (s), 2846.93 (s), 2362.80 (m), 1602.85 (s), 1498.69 (w), 1446.61 (m), 1365.60 (s), 1313.52 (m), 1172.72 (w), 993.34 (w ), 906.54 (w), 844.82 (w), 798.53 (s), 640.37 (w), 607.58 (w), 478.35 (w), 416.62 (m).
[0042] 1 H NMR (CDCl 3 , 500 MHz)...
Embodiment 3
[0046] Preparation of tricyclohexyl tin quinoline-6-carboxylate complex:
[0047] Add 0.3848 g (1 mmol) of tricyclohexyltin hydroxide, 0.1739 g (1 mmol) of quinoline-6-carboxylic acid, and 12 mL of anhydrous methanol into the microwave reaction tank in sequence. Microwave reaction was performed at 800 W and 100 °C for 120 min. After the reaction, cool naturally, filter, and the solvent volatilizes naturally at room temperature to crystallize to obtain white crystals, which are tricyclohexyltinquinoline-6-carboxylate complexes. Yield: 63%, melting point: 94-96 °C.
[0048] Elemental analysis (C 28 h 39 NO 2 Sn): theoretical values: C, 62.24; H, 7.28; N, 2.59. Found: C, 62.22; H, 7.25; N, 2.56.
[0049] IR(KBr, v / cm -1 ): 2920.23 (s), 2846.93 (s), 2362.80 (m), 1602.85 (s), 1498.69 (w), 1446.61 (m), 1365.60 (s), 1313.52 (m), 1172.72 (w), 993.34 (w ), 906.54 (w), 844.82 (w), 798.53 (s), 640.37 (w), 607.58 (w), 478.35 (w), 416.62 (m).
[0050] 1 H NMR (CDCl 3 , 500 MHz) ...
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