Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polymannuronic acid sulfate

A technology of uronic acid sulfate and nectar, applied in the field of new polymer compounds, can solve the problems of high price, easy drug resistance, single link, etc., and achieve the effect of cheap price

Inactive Publication Date: 2003-06-18
OCEAN UNIV OF CHINA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are only a dozen anti-AIDs drugs approved by the FDA, and generally have a single action link, are prone to drug resistance, have large toxic and side effects, and are expensive, and cannot effectively control the rapid spread of AIDs. AIDS medicine is a very urgent task

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] Take kelp, soak it in water to remove impurities and soften it, cut it into pieces for liquefaction, wash it with Na 2 CO 3 After liquefaction, impurities with a specific gravity close to 1 float to the upper layer for coarse filtration, and then fine filtration with a 300-500-mesh filter to filter out the residue. Coagulate by calcification method (or acidification method), and then squeeze and dehydrate so that the moisture content of the generated alginic acid is 60-65% (by weight). Neutralize with base in an alcoholic medium, then filter off the solid sodium alginate. Wash the sodium alginate with 95% alcohol, and then dehydrate it so that its water content is controlled at about 20%. Dissolve the sodium alginate to make it a 1% (by weight) aqueous solution, add alginase at a pH of 7 and React at 35°C for 5 hours, then heat to inactivate the enzyme, cool, centrifuge, grade with ethanol, then dissolve the degraded sodium alginate obtained by grade to make it a 2% a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A polymannuronic acid sulfate with anti-AIDS activity contains the primary molecular skeletons: the mannuronic acid linked with beta-D (1-4) and the guluronic acid linked with beta-L (1-4). The SO3Na is introduced to the hydroxy position on C2 and C3 of carbon ring. Its preparing process includes dewatering sodium alginate, dissolving, centrifugal separation, classifying with alcohol, dissolving the classified and degradated alginic acid, neutralizing with alkali, separating out solid, dewatering with alcohol, sulforating with chlorosulfonic acid, neutralizing with alkali, dewatering with alcohol and drying. It can be used to prepare anti-AIDS medicines.

Description

technical field [0001] The invention relates to a new high molecular compound, in particular to a medicinal polymannuronic acid sulfate. technical background [0002] AIDS (AIDs) is one of the most dangerous infectious diseases in the world. Since the first patient was discovered in 1981, the number of people infected worldwide has reached nearly 40 million, and the number of new infections is still increasing at a rate of 16,000 every day. At present, there are only a dozen anti-AIDs drugs approved by the FDA, and generally have a single action link, are prone to drug resistance, have large toxic and side effects, and are expensive, and cannot effectively control the rapid spread of AIDs. AIDS medicine is a very urgent task. Contents of the invention [0003] The purpose of this invention is to provide a polymannuronic acid sulfate, which is a new compound capable of treating various diseases including AIDS. [0004] A method for preparing polymannuronic acid sulfate, w...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/715A61P1/16A61P37/00C08B37/00
Inventor 管华诗
Owner OCEAN UNIV OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com