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Modular integrated bone regeneration and repair capacity test chip and preparation method and application thereof

An ability testing, integrated bone technology, applied in the field of biomedical engineering, can solve the problems of low screening efficiency, inconspicuous comparison, waste of animal resources, etc., to reduce the influence of uncontrollable variables, ensure experimental results, and reduce experimental costs. Effect

Pending Publication Date: 2020-05-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to individual differences in animals, the comparison between different experimental groups is not obvious
In addition, the screening efficiency of each single factor is not high, which will cause a waste of economic, human and animal resources

Method used

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  • Modular integrated bone regeneration and repair capacity test chip and preparation method and application thereof
  • Modular integrated bone regeneration and repair capacity test chip and preparation method and application thereof
  • Modular integrated bone regeneration and repair capacity test chip and preparation method and application thereof

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Embodiment

[0048] A modular integrated bone regeneration and repair ability test chip regeneration and repair ability test chip, including a substrate and a plurality of test units, the substrate is used to integrate and fix the test units, and each test unit corresponds to a specific test parameter , the test unit body and the substrate are provided with a mutually fitting structure, which is used to ensure the assembly between the unit body and the substrate and the stability of the chip after assembly.

[0049] As an option, in the above test chip, different test units are isolated from each other, so as to ensure that the environment of a single test unit is relatively independent and avoid mutual influence.

[0050] As an optional mode, in the above-mentioned test chip, the test unit body and the substrate are connected in a detachable manner, which not only facilitates the assembly of the chip, but also facilitates the removal of each test unit body after the completion of the in vi...

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Abstract

The invention discloses a modular integrated bone regeneration and repair capacity test chip, and belongs to the technical field of biomedical engineering. The invention provides a modular assembled integrated bone regeneration and repair capacity test chip by combining a 3D printing technology with a computer chip modular integration theory. Test body units corresponding to different test parameters are integrated together, and key parameters beneficial to bone regeneration and repair are screened out in a high-throughput manner through in-vivo or in-vitro experiments, so that the optimization design screening efficiency of biological materials is greatly improved, experimental animals are reduced, the experimental expenditure and manpower resources are saved, meanwhile, the influence ofuncontrollable difference factors in many experiments on experimental results is avoided, and the modular integrated bone regeneration and repair capacity test chip can be used for high-throughput accurate screening of bone tissue regeneration biological materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to a test chip for bone regeneration and repair ability, a preparation method and application thereof. [0002] technical background [0003] Bone defect, that is, the destruction of the structural integrity of bone, is a common clinical disease. Irreversible bone defects caused by bone defects and osteoporosis, bone tumor resection, accident trauma, and congenital deformities have always been one of the major clinical challenges, resulting in a high demand for bone repair materials. According to statistics, more than 3.5 million patients need bone transplantation every year in my country, and the number is growing rapidly. With the improvement of people's health level, patients are no longer satisfied with orthopedic implants to relieve pain and restore basic motor functions, but to restore their original functions to the maximum extent. [0004] Current...

Claims

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Application Information

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IPC IPC(8): A61F2/46G01N33/50
CPCA61F2/468G01N33/5044
Inventor 周长春樊渝江张勃庆雷皓远李正勇宋平吴丽娜
Owner SICHUAN UNIV
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