Traditional Chinese medicine composition for treating knee osteoarthritis

Abstract

The invention provides a traditional Chinese medicine composition for treating osteoarthritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from from the following raw material medicines in parts by weight: 10-20 parts of poria cocos, 5-15 parts of cassia twigs, 2-8 parts of rhizoma atractylodis, 2-8 parts of cortex phellodendri, 2-8 parts of radix stephaniae tetrandrae, 2-8 parts of polyporus umbellatus, 2-8 parts of rhizoma drynariae, 5-15 parts of rhizoma corydalis and 3-9 parts of radix cyathulae. The composition disclosed by the invention has the functions of tonifying spleen, promoting diuresis, dispelling wind, clearing heat, dredging collaterals and relieving pain, and is clinically applicable to patients suffering from rheumatic fever arthralgia in the attack stage of knee osteoarthritis, wherein the patients have the symptoms of swelling, pain, unfavorable flexion and extension and even local pyrexia, redness and swelling of joints, fat and big tongue body with tooth prints, yellow and greasy tongue coating and few pulse strings. When the composition provided by the invention is used for intervening in a rabbit with knee osteoarthritis, results show that the composition can relieve symptoms like joint swelling and skin temperature rise of the rabbit with knee osteoarthritis, improve joint functions, reduce the contents of IL-1[beta], TNF[alpha], PGE2 and NO in joints, relieve synovitis and delay the progress of knee osteoarthritis. Clinical observation results show that the composition provided by the invention has theeffects of relieving swelling and pain and improving joint functions for patients with knee osteoarthritis.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating osteoarthritis. Background technique [0002] Osteoarthritis is a multi-directional, multi-level, and varying degrees of chronic inflammation involving bone, synovium, joint capsule, and other joint structures with articular cartilage degeneration as the core. The main clinical manifestations are joint pain, swelling and functional limitation, the pain is aggravated after activities and weight-bearing, relieved after rest, and there are morning stiffness and stickiness, which can be divided into symptomatic (acute attack period) and asymptomatic (also known as Radiological Osteoarthritis), in particular, ictal osteoarthritis seriously affects the quality of life of patients. For the treatment of osteoarthritis, especially at the attack stage, there is still no effective treatment. Western medicine mostly uses non...

AI Technical Summary

Problems solved by technology

As mentioned above, most of the current TCM clinical treatment drugs focus on nourishing the liver and kidney, and have the functions of invigorating the spleen and expelling dampness, clearing heat and diuresis, dredging collaterals and relieving pain, and can obviously relieve the symptoms of osteoarthritis joint swelling, pain, and functional limitation during the attack stage, and improve The quality of life of patients, no effective drugs to delay the progression of the disease

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