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Elasto-optic modulation polarization imaging biosensing system of double-period nanopore chip

An elastic-optical modulation and biosensing technology, applied in the field of biosensing systems, can solve the problems of limited dynamic range of SPR sensors, inability to achieve high-throughput detection, etc., to ensure sensitivity and detection accuracy, good work stability, high performance The effect of sensitive biosensing

Pending Publication Date: 2020-06-05
ZHONGBEI UNIV
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Problems solved by technology

[0005] Aiming at the above-mentioned technical problems that the dynamic range of SPR sensor detection is limited and high-throughput detection cannot be realized, the present invention provides a high-precision, high-sensitivity, multi-channel, high-throughput dual-period nanopore chip elasto-optic modulation polarization imaging biosensing system

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Embodiment Construction

[0025] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

[0026] A dual-period nanopore chip elasto-optical modulation polarization imaging biological sensor system, such as figure 1 As shown, it includes detection laser light source 1, expanded beam collimation module 2, 45° polarizer 3, elastic-light modulator 4, dual-period nanopore biosensing chip 5, -45° analyzer 6, CCD imaging detection Detector 7, the side of the detection laser light source 1 is sequentially provided with a beam expandin...

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Abstract

The invention belongs to the technical field of biosensing systems, and especially relates to an elasto-optic modulation polarization imaging biosensing system of a double-cycle nanopore chip. A beamexpanding collimation module, a 45-degree polarizer, an elasto-optical modulator, a double-period nanopore biosensor chip, a-45-degree analyzer and a CCD imaging detector are sequentially arranged onone side of the detection laser light source. The CCD imaging detector is connected with the control computer and a elasto-optical modulator driving controller; the control computer is connected withthe elasto-optical modulator driving controller, the detection laser light source is connected with a programmable control pulse generator, the programmable control pulse generator is connected with the elasto-optical modulator driving controller, and the elasto-optical modulator driving controller is connected with the elasto-optical modulator. According to the invention, real-time polarization imaging detection of the double-cycle nanopore array is realized, and in-situ, rapid, real-time, non-labeled, high-precision, high-sensitivity, multi-channel and high-flux sensing measurement of biomolecules is realized. The biosensor is used for biosensing measurement.

Description

Technical field [0001] The invention belongs to the technical field of biological sensing systems, and specifically relates to a elasto-optical modulation polarization imaging biological sensing system of a double-period nanopore chip. Background technique [0002] Information analysis such as biomolecular recognition, affinity kinetics, and marker concentration can not only provide reliable experimental basis for drug development and testing, but also provide reasonable guidance for disease diagnosis, disease monitoring and control. In recent years, biosensors developed based on technologies such as radioimmunoassay, fluorescent labeling, micro-mass measurement, electrochemistry, and plasmon enhancement have been widely used in food safety, pharmaceuticals, clinical testing, biomedicine, environmental toxin monitoring and other fields . At the same time, the development of high-precision, high-sensitivity, rapid, miniaturized, low-cost, and high-throughput biosensing methods an...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/21G01N21/17
CPCG01N21/21G01N21/1717G01N2021/1725
Inventor 李克武王爽
Owner ZHONGBEI UNIV
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