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Application of ketone compound in treatment of fatty liver

Active Publication Date: 2020-06-12
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the clinical treatment of alcoholic fatty liver mainly requires patients to abstain from alcohol, and there is no specific drug treatment

Method used

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  • Application of ketone compound in treatment of fatty liver
  • Application of ketone compound in treatment of fatty liver
  • Application of ketone compound in treatment of fatty liver

Examples

Experimental program
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Embodiment

[0037] Heat and reflux the whole plant of Pseudomonas gentiana (3kg) in an ethanol solution with a net volume fraction of 70% to obtain 1053.4g of extract, extract with chloroform-water, and pass the water layer (670g) through D101 macroporous adsorption resin Treatment (water-volume fraction 95% ethanol solution-acetonitrile) yielded 332.4 g, 294.9 g and 5.1 g of water, 95% ethanol solution and acetonitrile eluates, respectively. The eluate (200 g) with a volume fraction of 95% ethanol solution was separated by silica gel column chromatography to obtain 16 components in total. Component 9-6 (3 g) was separated and prepared by HPLC to obtain the compound demethyl gentianone (76.9 mg). In this embodiment, desmethyl gentianone (DMB) represented by the following formula is obtained, which can be used as an active ingredient of a medicine.

[0038]

[0039]The model of alcoholic fatty liver was induced by feeding mice with chronic and acute ethanol to simulate the alcoholic fa...

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Abstract

The invention provides an application of a medicinal composition in preparation of a medicine for treating fatty liver. The medicinal composition comprises a ketone compound represented by the following formula, wherein R is H or C1-C6 alkyl groups.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a pharmaceutical composition for treating fatty liver (especially alcoholic fatty liver), wherein the pharmaceutical composition comprises Ketones. Background technique [0002] Fatty liver (fatty liver) refers to the pathological changes caused by excessive accumulation of fat in liver cells due to various reasons. Fatty liver is a common disease, especially with the continuous improvement of people's living standards, the way, way and amount of people's drinking have also undergone tremendous changes. Alcoholism and alcohol dependence are common, which virtually increases The likelihood that people will develop alcoholic liver disease (fatty liver disease) and eventually alcoholic cirrhosis. Among inpatients in hospitals, the proportion of patients with alcoholic liver disease is increasing year by year, and the degree of disease is proportional to the total amount of alcohol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P1/16
CPCA61K31/352A61P1/16Y02A50/30
Inventor 刘梦扬王涛张祎赵先银徐婧淇王丹韩立峰贾博娜
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE