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Application of protein tyrosine phosphatase SHP2 inhibitor in preparation of medicine for treating psoriasis

A technology of tyrosine phosphatase and inhibitor is applied in the application field of preparing medicines for treating psoriasis, and can solve problems such as unreported

Active Publication Date: 2020-06-12
NANJING UNIV
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Problems solved by technology

There has been no report about its unique pharmacological effects in the treatment of immune diseases, especially in the treatment of psoriasis

Method used

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  • Application of protein tyrosine phosphatase SHP2 inhibitor in preparation of medicine for treating psoriasis
  • Application of protein tyrosine phosphatase SHP2 inhibitor in preparation of medicine for treating psoriasis
  • Application of protein tyrosine phosphatase SHP2 inhibitor in preparation of medicine for treating psoriasis

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Embodiment 1

[0021] 1. Pharmacological experiment of SHP099: imiquimod-induced mouse psoriasis model [1]

[0022] C57BL / 6 female mice, aged 6-8 weeks, weighing 18-22 grams, were raised in an SPF animal room at 21±2°C, free to drink and eat, and alternate day and night for 12 hours. After the mouse was anesthetized with 1% pentobarbital sodium, the hair on the back of the mouse was shaved in an area of ​​about 2 cm×2 cm to expose the back skin. Two days later, the mice were randomly divided into 6 groups, normal group (Sham group), model group (Imiquimod, IMQ group), positive control group (Secukinumab group) 10mg / kg, SHP099 low, middle and high dose groups (1mg / kg). kg, 3mg / kg, 10mg / kg). In recent years, more and more studies have proved that the "IL-23 / Th17 cell axis" plays a vital role in the pathogenesis of psoriasis. Among them, IL-17A is highly expressed in psoriasis-affected skin, and drugs targeting this target have also shown excellent effects. The positive control drug Secukin...

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Abstract

The invention belongs to the technical field of pharmacy. According to the application of a protein tyrosine phosphatase SHP2 inhibitor SHP099 in preparation of the medicine for treating psoriasis, aiming at an imiquimod-induced mouse psoriasis-like disease model, the SHP099 can effectively improve epidermal thickening of mouse skin lesion tissues, inflammatory cell infiltration and the level of inflammatory factors in mouse serum. At the cellular level, the SHP099 can significantly reduce the release of inflammatory factors related to psoriasis.

Description

technical field [0001] The present invention relates to a new application of SHP099, an inhibitor of protein tyrosine phosphatase SHP2, in particular to the application of SHP099 in the preparation of medicines for treating psoriasis. Background technique [0002] SHP099 was developed as an allosteric inhibitor of the protein tyrosine phosphatase SHP2 in 2016, and the research on this compound mainly focuses on antitumor aspects. So far, there is no report about its unique pharmacological effect in treating immune diseases, especially in treating psoriasis. The present invention mainly finds that SHP099 has a significant improvement effect on the mouse psoriasis-like model. [0003] The structural formula of SHP099 is as follows: [0004] Contents of the invention [0005] Purpose of the invention: [0006] The present invention provides a new application of SHP2 inhibitor SHP099. [0007] Technical solutions: [0008] Application of protein tyrosine phosphatase SH...

Claims

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Application Information

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IPC IPC(8): A61K31/497A61P17/06
CPCA61K31/497A61P17/06
Inventor 孙洋徐强朱雨雨郭文洁
Owner NANJING UNIV
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