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A kind of preparation method and application of polyglycerol modified zein

A technology for modifying zein and polyglycerol, which is applied in the field of chemical modification of natural proteins, can solve the problems of poor water solubility of zein and achieve the effect of improving water solubility

Active Publication Date: 2021-08-24
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The main purpose of the present invention is to propose a preparation method and application of polyglycerol modified zein, aiming at solving the problem of poor water solubility of zein

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  • A kind of preparation method and application of polyglycerol modified zein
  • A kind of preparation method and application of polyglycerol modified zein
  • A kind of preparation method and application of polyglycerol modified zein

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[0037] Polyglycerol is a flexible hydrophilic aliphatic polyether polyol with good water solubility, biocompatibility and thermal stability. Compared with polyethylene glycol commonly used for hydrophilic modification, polyglycerol has lower It has great potential in replacing hydrophilic polymers such as polyethylene glycol. In order to enhance the hydrophilicity of zein or modify it into an amphiphilic protein, and break through the limitation of zein in aqueous solution, the present invention proposes a method for preparing polyglycerol-modified zein, Using polyglycerol as a hydrophilic substance to chemically modify zein to synthesize a zein-polyglycerol graft with excellent water solubility, figure 1 Shown is an embodiment of the preparation method of the polyglycerol-modified zein proposed by the present invention. see figure 1 , in this embodiment, the preparation method of the polyglycerol modified zein comprises the following steps:

[0038] S10, mixing polyglycero...

Embodiment 1

[0058] Weigh 5g decaglycerin and dissolve it in 100mL distilled water, add 1.4g sodium periodate, and react in the dark for 30min at room temperature; in addition, weigh 5g zein and dissolve it in 100mL KCl-NaOH buffer solution (pH=12.0) . Add the zein solution to the decaglycerol solution after the reaction, stir at room temperature for 30 minutes to make it evenly mixed, and then put the mixed solution in an oil bath at 80° C. to mix and react for 4 hours. After the reaction, the pH was adjusted to 7.0, centrifuged at 5000rmp / min for 10min, the obtained supernatant was dialyzed with deionized water for 24h, and the retentate was freeze-dried to obtain decaglycerol-modified zein.

Embodiment 2

[0060] Weigh 5g hexaglycerin and dissolve it in 100mL distilled water, add 2.32g sodium periodate, and react in the dark for 40min at room temperature; in addition, weigh 5g zein and dissolve it in 100mL KCl-NaOH buffer solution (pH=12.0) . The zein solution was added to the reacted hexaglycerol solution, stirred at room temperature for 30 minutes to make it evenly mixed, and then the mixed solution was placed in an oil bath at 80° C., mixed and stirred for 5 hours. After the reaction, the pH was adjusted to 7.0, centrifuged at 5000rmp / min for 10min, the obtained supernatant was dialyzed with deionized water for 24h, and the retentate was freeze-dried to obtain hexaglycerol-modified zein.

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Abstract

The invention discloses a preparation method and application of polyglycerol modified zein, and relates to the field of chemical modification of natural proteins. The preparation method of the polyglycerol-modified zein comprises the following steps: mixing polyglycerol, sodium periodate and water to undergo an oxidation reaction to obtain a polyglyceraldehyde solution; preparing the zein into a solution, adding it to In the polyglyceraldehyde solution, a dehydration condensation reaction occurs to obtain polyglycerol modified zein. The invention changes the surface hydrophilicity of the zein by oxidizing the polyglycerin to polyglyceraldehyde, and then reacts with the zein, thereby improving the water solubility of the zein.

Description

technical field [0001] The invention belongs to the field of chemical modification of natural proteins, and in particular relates to a preparation method and application of polyglycerol-modified zein. Background technique [0002] Zein is an alcohol-soluble protein derived from corn. It has biodegradability and biocompatibility. It is suitable for the fields of food and medical materials and is a good carrier for the delivery system of biologically active substances. However, its non-polar amino acid ratio exceeds 50%, and its isoelectric point is 6.8, which makes zein insoluble and aggregates in neutral solutions close to the isoelectric point, resulting in the instability of the delivery system, which greatly limits Its application in food, medicine and other industries. Contents of the invention [0003] The main purpose of the present invention is to propose a preparation method and application of polyglycerol modified zein, aiming at solving the problem of poor water...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08H1/00C08J3/03C08L91/00C08L89/00
CPCC08H1/00C08J3/03C08J2391/00C08J2489/00
Inventor 贺军波朱佩佩黄双双韩立娟张维农
Owner WUHAN POLYTECHNIC UNIVERSITY
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