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An expandable stent and a method for promoting a natural intracranial angiogenesis process, and use of the expandable stent in the method for promoting a natural intracranial angiogenesis process

A technique for intracranial blood vessels and blood vessels, applied in the field of expandable stents, which can solve problems such as obstruction

Pending Publication Date: 2020-06-16
CEROFLO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some studies suggest that the use of metal stents may push plaque into adjacent, previously unaffected blood vessels through a process called "snow plowing."
The arterial structure in the brain is highly branched, and a recognized problem with existing stents is shoveling material from the stenosis into arterial side branches, or so-called "perforator" arteries, thereby blocking them and causing stroke

Method used

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  • An expandable stent and a method for promoting a natural intracranial angiogenesis process, and use of the expandable stent in the method for promoting a natural intracranial angiogenesis process
  • An expandable stent and a method for promoting a natural intracranial angiogenesis process, and use of the expandable stent in the method for promoting a natural intracranial angiogenesis process
  • An expandable stent and a method for promoting a natural intracranial angiogenesis process, and use of the expandable stent in the method for promoting a natural intracranial angiogenesis process

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0204] enter

[0205]

[0206] calculate

[0207]

[0208] in conclusion

[0209] For a 92% stenosis, the stent 200 of this example can increase the cross-sectional area of ​​the stenotic hole by more than 3000%, while enlarging the vessel diameter by only 10%.

example 2

[0211] enter

[0212]

[0213] calculate

[0214]

[0215] in conclusion

[0216] For a stenosis of 88%, the stent 200 of this example can increase the cross-sectional area of ​​the stenotic hole by more than 1500%, while expanding the vessel diameter by only 10.3%.

example 3

[0218] enter

[0219]

[0220]

[0221] calculate

[0222]

[0223] in conclusion

[0224] For a 75% stenosis, the exemplary stent 200 can increase the stenotic hole cross-sectional area by more than 384%, while only expanding the vessel diameter by 11.4%.

[0225] Therefore, as can be seen from the above three examples, when used for stenosis of different pore diameters, the stent 200 according to the present invention having different sizes can significantly increase the cross-sectional area of ​​the stenosis hole, while the central portion 5 of the stent 200 The radially outward action on the stenosis-forming material produced a smaller increase in vessel diameter. Typically, the increase in cross-sectional area of ​​a hole extending through a stenosis may range from 300% to over 3000%, while the increase in diameter of a blood vessel adjacent to a stenosis ranges from 10% to 12%.

[0226] In embodiments of the invention in which the stent is not described as be...

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Abstract

An expandable stent (1) to enhance the supply of blood to downstream tissue which is being supplied with blood through a diseased intracranial artery (100) with a stenosis (102) formed therein by plaque with a bore (103) therethrough. The expandable stent (1) comprises first and second end portions (3,4) joined by a central portion (5). The central portion (5) is configured in the expanded state of the stent (1) to be 10 located in the bore (103) of the stenosis (102) with the first and second end portions (3,4) abutting non- diseased parts (104,106) of the artery (100) adjacent the proximal and distal ends (105,107) of the stenosis (102) for anchoring the stent (1) in the artery (100). The central portion (5) with the stent (1) in the expanded state is configured to apply a radial outwardpressure to the stenosis (102) such that the diameter of the bore (103) of the stenosis (102) is maintained at its current diameter or increased to 15 approximately 50% of the non-diseased parts (104,106) of the artery (100).

Description

technical field [0001] The present invention relates to an expandable stent, in particular, but not limited to, an expandable stent for the treatment of intracranial atherosclerotic disease (ICAD). Stents provide a means of restoring sufficient blood flow velocity to mitigate the risk of hypoxia, ischemia, and infarction, while mechanically controlling the stent to prevent snow-ploughing of the lesion. Additionally, the stents of the present invention are configured to perfuse downstream tissue to a hypovolemic state to promote natural intracranial angiogenesis. [0002] The present invention also relates to a method of promoting the natural intracranial angiogenesis process, and the present invention also relates to the use of an expandable stent in a method for promoting the natural intracranial angiogenesis process. The present invention also relates to methods of treating intracranial atherosclerotic disease (ICAD). The invention also relates to the use of the expandable...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61F2/91
CPCA61F2/90A61F2/91A61F2230/001A61F2250/0039A61F2210/0014A61F2002/8486A61F2/848A61F2/94A61F2230/0067A61F2250/0098
Inventor S·T·安德松E·O·布拉迪
Owner CEROFLO LTD
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