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Drug-loaded composite hernia patch

A drug-loading and hernia technology, applied in medical science, conjugated synthetic polymer rayon, single-component polyester rayon, etc., can solve problems such as strong foreign body sensation, local bleeding, inflammation, etc., and achieve simplified production Process, avoiding organ adhesion, and good biocompatibility

Pending Publication Date: 2020-06-19
杭州爱多倍生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] To sum up, although the hernia mesh patch has been considered as the safest and most effective way to treat hernia, there are still many problems, such as strong foreign body sensation after surgery, local bleeding, inflammation, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A drug-loaded composite hernia patch, which includes a polylactic acid / polypropylene sheath-core structural fiber base sheet and a drug-loaded slow-release layer, is combined by heat and pressure, and has a thickness of 0.2mm to 3.5mm. The specific preparation method is as follows:

[0025] Step 1: Add 0.1w% developer to medical-grade polypropylene raw materials, add other processing aids appropriately, granulate, and dry for later use; dry polylactic acid raw materials at 105°C for 2 hours for later use, and select polylactic acid with a molecular weight of 50,000- 200000;

[0026] Step 2: take the above-mentioned polypropylene mixed with developer as the core layer, polylactic acid as the skin layer, and spin through the composite spinning box with composite spinneret components to obtain fibers with a diameter of 0.1-0.25mm, which are further wound, After warping and weaving, the polylactic acid / polypropylene sheath-core structure fiber substrate is obtained;

[002...

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PUM

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Abstract

The invention discloses a drug-loaded composite hernia patch and a preparation method thereof. The composite hernia patch comprises a polylactic acid / polypropylene skin-core structure fiber substrateand a drug-loaded slow-release layer which are combined together through hot pressing. The invention further provides a preparation method of the composite hernia patch. The method comprises the following steps: 1) preparing developer-doped polypropylene; 2) preparing polylactic acid / polypropylene skin-core structure fibers, and performing weaving to obtain the substrate; 3) preparing drug-loadedmicrospheres of an antibacterial drug, a hemostatic drug and an anesthetic drug; 4) preparing the drug-loaded slow-release layer through electrostatic spinning; and 5) performing hot pressing to obtain the finished product. The drug-loaded composite hernia patch avoids the problem of adhesion caused by direct contact between a polypropylene material and tissues, meanwhile, different drugs can be added to the drug-loaded slow-release layer according to needs, surgical healing is promoted, the polylactic acid material can be slowly degraded and absorbed in vivo, and discomfort of the patch is reduced after healing.

Description

Technical field: [0001] The invention relates to the field of biomedical materials, in particular to a drug-loaded composite hernia patch and a preparation method thereof. Background technique [0002] A hernia refers to the rupture or weakening of the peritoneum supporting the internal organs at a certain position due to surgical injury or pathological changes, so that the internal organs in the abdomen protrude outward through the rupture or weakened part, forming a local mass. Hernias generally occur in the groin, waist and navel, and can be divided into inguinal hernia, femoral hernia, umbilical hernia, incisional hernia, lumbar hernia, etc. Hernias generally cannot heal on their own, and when severe, affect the patient's walking and normal activities. If it is not treated in time, it can lead to intestinal ischemic necrosis and life-threatening. [0003] At present, the ideal method for treating hernia is hernia mesh repair, that is, the mesh material is used to cover ...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/04A61L31/06A61L31/14A61L31/16A61L31/18D01F8/14D01F8/06D01F1/10D01F6/92
CPCA61L31/048A61L31/06A61L31/14A61L31/148A61L31/16A61L31/18A61L2300/402A61L2300/404A61L2300/418D01F1/10D01F1/103D01F6/92D01F8/06D01F8/14C08L67/04C08L23/12
Inventor 马学所
Owner 杭州爱多倍生物科技有限公司
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