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Use of novel material based on carbon nanotube and phycoerythrin

A technology of phycoerythrin and new materials, which can be applied to non-active ingredient medical preparations, medical preparations containing active ingredients, wave energy or particle radiation treatment materials, etc. It can solve the problem of phycocyanin structure instability, photosensitive Weak effect, application limitations and other issues, to achieve the effect of improving photoconversion efficiency and stability, good stability, and good phototherapy effect

Active Publication Date: 2020-06-23
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the structure of phycocyanin is not very stable, and the photosensitization effect is weak, so its application as a photosensitizer is greatly limited.

Method used

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  • Use of novel material based on carbon nanotube and phycoerythrin
  • Use of novel material based on carbon nanotube and phycoerythrin
  • Use of novel material based on carbon nanotube and phycoerythrin

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1 A method for preparing a novel material based on carbon nanotube coupling phycoerythrin, comprising the following steps:

[0032] (1) Prepare a carboxylated single-walled carbon nanotube dispersion with a concentration of 1 mg / mL with deionized water, take 1 mL of the carboxylated single-walled carbon nanotube dispersion, dilute it 50 times, take 10 mL, and ultrasonicate for 90 minutes;

[0033] (2) Add 0.2 mL of 9 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) solution and 0.2 mL of 5 mg / mL dissolved in PBS buffer to the above dispersion mL of N-hydroxysulfosuccinimide (NHS) solution dissolved in PBS buffer (with the addition of EDC and specific weight ratios of NHS to carboxylated SWNTs of 9:1 and 5:1), ultrasonically dispersed 30min and placed at room temperature (25°C) under magnetic stirring for 18h; the PBS buffer is 50mM sodium phosphate buffer with a pH of 7.0;

[0034] (3) Then add 4 mg of phycoerythrin to the above reaction solution, t...

Embodiment 2

[0036] Embodiment 2 A method for preparing a novel material based on carbon nanotube-coupled phycoerythrin, comprising the following steps:

[0037] (1) Prepare a carboxylated single-walled carbon nanotube dispersion with a concentration of 1 mg / mL with deionized water, take 1 mL of the carboxylated single-walled carbon nanotube dispersion, dilute it 20 times, take 10 mL, and ultrasonicate for 90 minutes;

[0038] (2) Add 0.5mL 9mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) solution and 0.5mL 5mg / mL dispersed in PBS buffer to the above dispersion mL of N-hydroxysulfosuccinimide (NHS) solution dispersed in PBS buffer (the specific weight ratios of EDC and NHS to single-walled carbon nanotubes were 9:1 and 5:1), ultrasonically dispersed for 30 min and Stir magnetically at room temperature (25° C.) for 18 hours; the PBS buffer is 50 mM sodium phosphate buffer with a pH of 7.0;

[0039] (3) Then add 10 mg of phycoerythrin to the above reaction solution, the specific a...

Embodiment 3

[0041] Embodiment 3 A method for preparing a novel material based on carbon nanotube-coupled phycoerythrin, comprising the following steps:

[0042] (1) Prepare a carboxylated single-walled carbon nanotube dispersion with a concentration of 1mg / mL with deionized water, take 1mL of the carboxylated single-walled carbon nanotube dispersion, dilute it 10 times, take 10mL, and first sonicate for 90min;

[0043] (2) Add 1mL 9mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) solution and 1mL 9mg / mL dissolved in PBS buffer to the above dispersion N-hydroxysulfosuccinimide (NHS) solution in PBS buffer (the specific weight ratios of EDC and NHS to single-walled carbon nanotubes are 9:1 and 5:1), ultrasonically dispersed for 30min and placed in Magnetic stirring at room temperature (25° C.) for 18 h; the PBS buffer is 50 mM sodium phosphate buffer with a pH of 7.0;

[0044] (3) Then add 15 mg of phycoerythrin to the above reaction solution, the specific amount of addition is 15...

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Abstract

The invention discloses use of a novel material based on a carbon nanotube and phycoerythrin, namely use of the novel material as a photosensitizer for treating tumors through phototherapy. Accordingto the use, the chemical inertness of a single-wall nanotube can be overcome, and the photoconversion efficiency of the single-wall nanotube is improved; meanwhile, by linking the single-wall nanotubewith the phycoerythrin, the stability of the phycoerythrin is improved, and a relatively durable effect is achieved. The novel material has good stability and further has excellent effect on treatment of cancers when serving as the photosensitizer which has a photo-thermal effect and is used for treating cancers through the phototherapy.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to the use of a new material based on carbon nanotubes and phycoerythrin. Background technique [0002] Single-walled carbon nanotubes can be considered as the extension of fullerene molecules in a cage structure in one dimension, or as a closed tubular structure formed by curling graphite layers. Drugs related to single-walled carbon nanotubes must first pass through the human circulatory and metabolic systems before they can reach the designated tissue sites. Due to its chemical inertness, it is difficult to interact with other molecules, so the modified single-walled carbon nanotubes can be used as carriers to couple and transport various biomolecules, such as drugs, proteins, DNA and RNA, etc., and they enter cells through endocytosis , better results can be obtained. At the same time, as an excellent photothermal material, carbon nanotubes have strong absorp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/55A61P35/00
CPCA61K41/0052A61K41/0057A61K47/55A61P35/00A61K2300/00
Inventor 赵华伟蒲洋杜若冉邓琳陈帅钰李文军
Owner LUDONG UNIVERSITY
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