Application of calyx seu fructus physalis extract in preparation of medicines for treating oral ulcers
A technique for oral ulcers and brocade lanterns, which is applied to the application field of broccoli lantern extracts in the preparation of medicines for treating oral ulcers, and can solve the problems of few reports on the extraction and refining of active ingredients, and no broccoli lanterns mouth ulcers and the like.
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Embodiment 1
[0021] A preparation method of brocade lantern extract, the specific steps are as follows:
[0022] (1) extract the brocade lantern with 30 times the mass of 70% ethanol for 2 hours, and repeat the operation once more to obtain the brocade lantern extract;
[0023] (2) The brocade lantern extract with a concentration of 8.338mg / mL~16.675mg / mL obtained in step (1) is slowly passed through the pretreated AB-8 type macroporous resin chromatographic column at a flow rate of 1BV / h, and adsorbed for 1h, Rinse with 2BV of distilled water at a flow rate of 2BV / h;
[0024] (3) After the Molish reaction of the eluent is negative, elute with 50% ethanol at a flow rate of 2BV / h, collect the eluate between 0.3 and 0.8BV, concentrate to dryness under reduced pressure at 60°C and 95kPa, Obtain the brocade lantern extract.
Embodiment 2
[0025] The preparation of embodiment 2 film
[0026] The film preparation method is as follows: Weigh 2.7g polyvinyl alcohol (PVA) and 0.3g carboxymethylcellulose sodium (CMC-Na), soak in 20mL distilled water overnight; after fully swelling, heat and stir in a 90°C water bath until completely dissolved , mix the two and let stand to cool to room temperature; then add 0.5g glycerin and 0.5g brocade lantern extract prepared in Example 1 and stir carefully to avoid bubbles to obtain a mixed solution. Spread the mixed solution evenly on a clean and dry glass plate, and divide the area on the back of the glass plate according to the size of 1.5cm×1.5cm. After drying at room temperature for 48 hours, cut the film with a knife to obtain the finished film.
Embodiment 3
[0027] The preparation of embodiment 3 lozenges
[0028] The preparation method of buccal tablet is as follows: take 150g of brocade lantern extract prepared in Example 1, grind it into a fine powder; add 125g of powdered sugar and 250g of starch, mix well; add 15% starch slurry 15-20g to make soft material, and pass through a 20-mesh sieve , dried at 60°C, sized with a 18-mesh sieve, added with 5g of menthol and 5g of magnesium stearate, mixed evenly, compressed into tablets, inspected and subpackaged to obtain finished buccal tablets.
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