Preparation method of silodosin compound and pharmaceutical composition
A technology of silodosin and compounds, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the cumbersome and time-consuming preparation methods, low production efficiency, high production costs, etc. problems, to achieve the effect of less impurities, high production efficiency, and increase production
Inactive Publication Date: 2020-07-10
NANJING MEIRUI PHARMA CO LTD
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Problems solved by technology
[0003] The purpose of the present invention is to provide a preparation method of silodosin compound and pharmaceutical composition, to solve the problem that the preparation method of the existing silodosin compound proposed in the above-mentioned background technology is cumbersome and time-consuming, the solvent is highly toxic, and the production efficiency is not high , while the production cost is relatively large
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[0024] In order to make the technical solutions of the present invention clearer and clearer to those skilled in the art, the present invention will be further described in detail below in conjunction with examples, but the embodiments of the present invention are not limited thereto.
[0025] The preparation method of a kind of silodosin compound provided by the present embodiment, the specific method is as follows:
[0026] Step a: dissolving the antioxidant in distilled water, stirring evenly for later use;
[0027] Step b: crushing and grinding the silodosin raw material in a grinder, and using a sieve to screen to 80-140 mesh for later use;
[0028] Step c: Weighing the filler and the lubricant respectively according to the weight ratio and fully mixing them for later use;
[0029] Step d: Weigh the silodosin and the adhesive respectively according to the weight ratio and fully mix them for later use;
[0030] Step e: Weigh the pregelatinized starch according to the wei...
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The invention discloses a preparation method of a silodosin compound and a pharmaceutical composition. The preparation method comprises the following steps: step a, dissolving an antioxidant in distilled water, and performing uniform stirring for standby application; step b, crushing and grinding silodosin raw materials in a grinder, and performing sieving by using a sieve to 80-140 meshes for standby application; step c, weighing a filler and a lubricant according to a weight ratio, and performing full mixing for standby application; step d, weighing silodosin and a binder according to a weight ratio, and performing full mixing for standby application; step e, weighing pregelatinized starch according to a weight ratio, performing full mixing, adding the weighed silodosin and binder, performing full mixing under stirring, and performing wet granulation; and step f, performing tabletting forming on the granulated material obtained in the step e. According to the preparation method of the silodosin compound and the pharmaceutical composition provided by the invention, the production process is simple, the production efficiency is higher, produced impurities are less, the yield of thesilodosin compound and the pharmaceutical composition is improved, and the production costs are further reduced.
Description
technical field [0001] The invention relates to a preparation method and a pharmaceutical composition of a silodosin compound, belonging to the technical field of medicine. Background technique [0002] Silodosin capsules are used to treat symptoms and signs caused by benign prostatic hyperplasia (BPH). Silodosin is a new generation of highly selective adrenergic α1A receptor blocker. On the one hand, it can effectively block the Adrenergic α1A receptors on the smooth muscle of the prostate, urethra, and trigone of the bladder relax bladder and prostate smooth muscle tissue, thereby increasing urine flow and reducing the chance of urinary reflux in the prostate: On the other hand, silodosin It has very low affinity for adrenaline α1A receptors (present in the peripheral vasculature and plays an important role in blood pressure regulation), and its side effects (headache, dizziness, etc.) are far less than those of similar drugs (terazosin, tamsol, etc.) Rosin et al), theref...
Claims
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IPC IPC(8): A61K9/20A61K31/4045A61K47/36A61K47/38A61K47/26A61P13/08
CPCA61K9/2059A61K9/2054A61K9/2095A61K9/2018A61K31/4045A61P13/08
Inventor 王先登毛逸飞
Owner NANJING MEIRUI PHARMA CO LTD