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Yellow-tea compound extract and application of yellow-tea compound extract to skin external application agent

A technology of extract and yellow tea, applied in the field of compound extract of yellow tea, can solve the problems of reduced skin adhesion, increased transdermal water loss, skin shrinkage in mice, etc.

Active Publication Date: 2020-07-10
SHANGHAI JAHWA UNITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, as reported in the article "Claudin-based tight junctions are crucial for the mammalian epidermal barrier" by Furuse and Hata, Claudin-1 deficiency directly leads to skin wrinkling in mice Shrinkage, severe dehydration, increased transepidermal water loss (TEWL) and decreased skin adhesion

Method used

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  • Yellow-tea compound extract and application of yellow-tea compound extract to skin external application agent
  • Yellow-tea compound extract and application of yellow-tea compound extract to skin external application agent
  • Yellow-tea compound extract and application of yellow-tea compound extract to skin external application agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: the preparation of yellow tea extract

[0057] Take by weighing 100g of yellow tea, make coarse powder (powdering machine model: Daedeok Pharmaceutical Machine DFY-600C), use 10 times of 70% ethanol (v / v) ultrasonic extraction for 45 minutes (ultrasonic instrument: Beijing Hongxianglong Biotechnology Co., Ltd. Company TGCXN-2B), filtered with filter paper (filter paper specification: 60*60cm fast filter paper), the filtrate was concentrated at 55°C, left standing overnight at 4°C, taken out, centrifuged at 3500rpm for 15 minutes at 3°C, and filtered with filter paper (filter paper specification: 60*60cm fast filter paper), finally formulated into a 1g / ml solution.

Embodiment 2

[0058] Embodiment 2: the preparation of yellow tea compound extract

[0059] Weigh honeysuckle: dandelion: angelica: honeysuckle (1:1:1:1) 200g, extract with 10 times deionized water for 1h, twice, filter with cotton, combine filtrate, add 95% ethanol (v / v) alcohol precipitation , stir evenly, let stand overnight, filter paper (filter paper specifications: 60*60cm fast filter paper), concentrate the filtrate to 1 times the crude drug amount, stand overnight at 4°C, centrifuge at 3500rpm for 15 minutes at 3°C, filter paper filter (filter paper specifications: 60*60cm fast filter paper), finally prepared into a 1g / ml solution, which is the extract A.

[0060] Take by weighing 200g of yellow tea, make coarse powder (powdering machine model: Daedeok Pharmaceutical Machine DFY-600C), use 10 times of 70% ethanol (v / v) ultrasonic extraction for 45 minutes (ultrasonic instrument: Beijing Hongxianglong Biotechnology Co., Ltd. Company TGCXN-2B), filtered through filter paper (filter pa...

Embodiment 3

[0062] Embodiment 3: the preparation of yellow tea compound extract

[0063]Weigh honeysuckle: dandelion: angelica: honeysuckle (2:2:1:1) 100g, extract with 10 times deionized water for 1h, twice, filter with cotton, combine filtrate, add 95% ethanol (v / v) alcohol precipitation , stir evenly, let stand overnight, filter paper (filter paper specifications: 60*60cm fast filter paper), concentrate the filtrate to 1 times the crude drug amount, stand overnight at 4°C, centrifuge at 3500rpm for 15 minutes at 3°C, filter paper filter (filter paper specifications: 60*60cm fast filter paper), finally prepared into a 1g / ml solution, which is the extract A.

[0064] Take by weighing 100g of yellow tea, make coarse powder (powdering machine model: Daedeok Pharmaceutical Machine DFY-600C), use 10 times of 70% ethanol (v / v) ultrasonic extraction for 45 minutes (ultrasonic instrument: Beijing Hongxianglong Biotechnology Co., Ltd. Company TGCXN-2B), filtered through filter paper (filter pap...

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Abstract

The invention discloses yellow-tea compound extract. The extract is prepared by the following method of (a) performing solvent extraction on flos lonicerae, herba taraxaci, radix angelicae sinensis and caulis Lonicerae with the weight ratio of (1-2) : (1-2) : (1-2) : 1 to obtain an extracting solution A; (b) carrying out ultrasonic extraction on yellow tea to obtain an extracting solution B; and (c) mixing the extracting solution A and the extracting solution B according to the weight ratio of 1 : (0.8-2.5) to obtain the final yellow tea compound extract. The invention also discloses an application of the yellow tea compound extract to skin moisturizing and / or skin barrier function maintaining and an application to preparation of a skin external application agent for skin moisturizing and / or skin barrier function maintaining.

Description

technical field [0001] The purpose of the present invention is to provide the compound yellow tea extract with moisturizing effect, which can promote the expression of keratinocyte tight junction protein (Claudin-1), and can be used as functional additive in cosmetics for skin care. Background technique [0002] The skin refers to the tissue on the surface of the body that covers the muscles. It is the largest organ of the human body and mainly undertakes functions such as protecting the body, perspiration, and feeling cold, heat, and pressure. The skin covers the whole body, protecting various tissues and organs in the human body from external substances such as pathogenic microorganisms and physical and other mechanical damage, effectively resisting external stimuli; the skin also maintains the loss of water, electrolytes and nutrients in the human body, effectively It maintains the stability of the internal environment of the human body and is a natural barrier to protect...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K8/9789A61P17/00A61Q19/00
CPCA61K8/9789A61Q19/00A61K36/82A61K36/355A61K36/288A61K36/232A61P17/00A61K2236/30A61K2300/00
Inventor 孙懿陈默祝乐李玲玉赵亚
Owner SHANGHAI JAHWA UNITED