A kind of gel reservoir and its preparation method and its application in the preparation of postoperative hemostatic preparation

A storage and gel technology, applied in the field of biomedicine, can solve the problems of weak adhesion, unable to achieve rapid hemostasis, easy to fall off, etc., to achieve good hemostasis effect, promote wound healing, and not easy to fall off.

Active Publication Date: 2021-05-18
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention solves the technical problem that the existing gel hemostatic material cannot realize rapid hemostasis, and the adhesion force is not strong, so it is easy to fall off, and provides a gel storage, which contains 40-55 parts by mass of phospholipids , 40-55 parts by mass of glyceride and 5-20 parts by mass of cosolvent

Method used

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  • A kind of gel reservoir and its preparation method and its application in the preparation of postoperative hemostatic preparation
  • A kind of gel reservoir and its preparation method and its application in the preparation of postoperative hemostatic preparation
  • A kind of gel reservoir and its preparation method and its application in the preparation of postoperative hemostatic preparation

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Effect test

Embodiment 1

[0035] A gel reservoir that can be used for postoperative hemostasis, prepared from the following raw materials in weight percentage: 50 parts by mass of soybean lecithin, 50 parts by mass of glyceryl dioleate, and 10 parts by mass of absolute ethanol, denoted as LG 50 / 50.

[0036] The preparation steps are as follows:

[0037] S1: Mix 50 parts by mass of phospholipids, 50 parts by mass of glycerides and 10 parts by mass of co-solvent on a mixer to completely dissolve the phospholipids and glycerides to obtain a gel precursor;

[0038] S2: Put the gel precursor obtained in step S1 into the injection barrel of the syringe, and then push the gel precursor into water, and the gel precursor will gel when it encounters water to form a gel, that is, a gel reservoir is obtained ,Such as figure 1 shown.

Embodiment 2

[0040] A gel reservoir that can be used for postoperative hemostasis, prepared from the following raw materials in weight percentage: 40 parts by mass of soybean lecithin, 40 parts by mass of glyceryl dioleate, and 5 parts by mass of absolute ethanol, denoted as LG 40 / 40.

[0041] The preparation steps are as follows:

[0042] S1: Mix 40 parts by mass of phospholipids, 40 parts by mass of glycerides and 5 parts by mass of co-solvent on a mixer to completely dissolve the phospholipids and glycerides to obtain a gel precursor;

[0043] S2: Put the gel precursor obtained in step S1 into the injection barrel of the syringe, and then push the gel precursor into water, and the gel precursor will gel when it encounters water to form a gel, that is, a gel reservoir is obtained .

Embodiment 3

[0045] A gel reservoir that can be used for postoperative hemostasis, prepared from the following raw materials in weight percentage: 55 parts by mass of soybean lecithin, 55 parts by mass of glyceryl dioleate, and 20 parts by mass of absolute ethanol, denoted as LG 55 / 55.

[0046] The preparation steps are as follows:

[0047] S1: Mix 55 parts by mass of phospholipids, 55 parts by mass of glycerides and 20 parts by mass of co-solvent on a mixer to completely dissolve the phospholipids and glycerides to obtain a gel precursor;

[0048] S2: Put the gel precursor obtained in step S1 into the injection barrel of the syringe, and then push the gel precursor into water, and the gel precursor will gel when it encounters water to form a gel, that is, a gel reservoir is obtained .

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Abstract

The invention relates to a gel storehouse, its preparation method and the application of postoperative hemostatic preparations, belonging to the technical field of biomedicine. The gel storage includes 40-55 mass parts of phospholipids, 40-55 mass parts of glycerides and 5-20 mass parts of cosolvent; or the outer gel storage is wrapped outside the inner gel storage; The outer gel reservoir includes 28-38 mass parts of phospholipids, 62-70 mass parts of glycerides and 1-8 mass parts of cosolvent, and the inner gel reservoir includes 40-55 mass parts of phospholipids, 40-70 mass parts of glycerides 55 parts by mass and 5-20 parts by mass of cosolvent. Preferably, the gel depot also includes a drug. The invention uses two raw materials of phospholipid and glyceride, and through mixing, the gel precursor can be quickly gelled when it meets water, so as to quickly seal the bleeding point. The inner gel of the double-layer reservoir has the characteristics of rapid gelation and high strength, which can quickly seal the bleeding point, and the outer gel has strong adhesion, which ensures that the entire gel system is not easy to fall off.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically relates to a gel reservoir, a preparation method thereof, and an application for preparing postoperative hemostatic preparations. Background technique [0002] Hemorrhage is one of the most common manifestations after trauma, but uncontrolled hemorrhage is considered to be an important cause of death in patients. Traditional hemostatic materials mainly include gauze, bandages, tourniquets and the like. However, traditional methods of hemostasis are at the cost of sacrificing blood supply to remote tissues, which can easily cause complications. [0003] Since then, many new hemostatic materials have been developed, such as zeolite, sponge, polymer materials, inorganic materials, nanomaterials and so on. But they also have many disadvantages. For example, zeolite materials will generate heat during the process of hemostasis, which may cause damage to the body. Inorgani...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L26/00A61K9/06A61K47/24A61K47/14A61K47/10A61K45/00A61P7/04A61P29/00A61P17/02
CPCA61K9/06A61K45/00A61K47/10A61K47/14A61K47/24A61L24/00A61L24/001A61L24/0015A61L24/0031A61L26/00A61L26/0061A61L26/0066A61L26/008A61L2300/402A61L2300/41A61L2300/418A61L2400/04A61P7/04A61P17/02A61P29/00
Inventor 罗亮黄丽萍张一漪孟凡玲
Owner HUAZHONG UNIV OF SCI & TECH
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