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Instant anti-infection wound care hydrogel material as well as preparation method and application thereof

A wound care and hydrogel technology, applied in bandages, medical science, etc., can solve the problems of loss of antibacterial ability, achieve high antibacterial ability, improve biodegradability, and high water absorption

Pending Publication Date: 2020-07-17
KUNMING YESHUI BIO TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The international application number is PCT / CN2017 / 080848, which discloses the modification of the amino group of chitosan by adding a-N-O-(C= O)-C(CH3)=CH2 groups are further copolymerized with water-absorbing polymers, thereby losing the antibacterial ability of the molecules

Method used

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  • Instant anti-infection wound care hydrogel material as well as preparation method and application thereof
  • Instant anti-infection wound care hydrogel material as well as preparation method and application thereof
  • Instant anti-infection wound care hydrogel material as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Chitosan-polyitaconic acid graft copolymer (CS-PIA) was synthesized by using itaconic acid as superabsorbent component monomer and N,N'-methylenebisacrylic acid amide (MBA) as crosslinking agent.

[0045] Step 1) Dissolve 1 g of chitosan (CS) in a beaker filled with 50 ml of deionized water, and add 5 ml of acetic acid solution in the beaker, and stir vigorously at room temperature until the gel forms a uniform solution A. Place the beaker in a water bath at 60 °C, and purge the solution with argon for 10 min to remove dissolved oxygen in the system.

[0046] Step 2) Add 0.5 g of ammonium persulfate (APS) to solution A of step 1), and stir the solution for 10 minutes.

[0047] Step 3) Dissolve 1 g of itaconic acid (IA) in 5 ml of a 50:50 NaOH aqueous solution (1 mol / L): ethanol mixture to prepare solution B1.

[0048] Step 4) Add solution B1, 100mg N,N'-methylene bisacrylamide (MBA) and 20ml deionized water in step 3) to solution A in which ammonium persulfate was adde...

Embodiment 2

[0056] Chitosan-polyacrylic acid graft copolymer (CS-PAA) was synthesized by using acrylic acid as superabsorbent monomer and N,N'-methylenebisacrylic acid amide as crosslinking agent.

[0057] Step 1) Dissolve 1 g of chitosan (CS) in a beaker filled with 50 ml of deionized water, and add 5 ml of acetic acid solution in the beaker, and stir vigorously at room temperature until the gel forms a uniform solution A. Place the beaker in a water bath at 60 °C, and purge the solution with argon for 10 min to remove dissolved oxygen in the system.

[0058] Step 2) Add 0.5 g of ammonium persulfate (APS) to solution A of step 1), and stir the solution for 10 minutes.

[0059] Step 3) Dissolve 1 g of acrylic acid (AA) in 5 ml of a 50:50 NaOH aqueous solution (1 mol / L): ethanol mixture to prepare solution B2.

[0060] Step 4) Add solution B1, 100mg N,N'-methylene bisacrylamide (MBA) and 20ml deionized water in step 3) to solution A in which ammonium persulfate was added in step 2). Cove...

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Abstract

The invention belongs to the field of medical engineering, and provides an instant anti-infection wound care hydrogel material which is a chitosan-based graft copolymer which is formed by polymerizingchitosan, an acrylic monomer and a cross-linking agent and has a structural formula (I). The material provided by the invention has high water absorbability and antibacterial ability. Chitosan has good antibacterial property, biocompatibility and biodegradability, has amino salt-NH3 + and hydroxyl-OH, and is convenient for graft polymerization of hydrophilic acrylic monomers under mild reaction conditions. In addition, due to the existence of amino, the chitosan-based polymer not only has good water absorption, but also has antibacterial activity.

Description

technical field [0001] The invention belongs to the field of materials and relates to wound care materials, in particular to an instant anti-infection wound care hydrogel material and its preparation method and application. Background technique [0002] Whether it is a war environment or a peaceful era, the treatment and care of wound bleeding and infection are inevitable challenges. In the case of severe blood loss, the basic principle of traditional hemostasis is to use a mechanical method to apply pressure with gauze to stop blood loss. For small wounds, the principle of action of bandages is the same. [0003] Recently, some local hemostatic drugs have been developed for the treatment of severe bleeding and are used in military and civilian emergency treatment. Among them, chitosan-based wound dressings are included. Chitosan is a derivative of natural biological material chitin. As a wound dressing, chitosan has the advantages of biodegradability, biocompatibility, an...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/06C08F222/38C08J3/075C08L51/02
CPCC08F251/00C08J3/075A61L26/008A61L26/0014A61L26/0061A61L26/0066A61L26/0023C08J2351/02A61L2300/232A61L2300/404C08F220/06C08F222/385C08L51/02C08L5/08
Inventor 陆恩扬
Owner KUNMING YESHUI BIO TECH LTD
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