Instant anti-infection wound care hydrogel material as well as preparation method and application thereof

A wound care and hydrogel technology, applied in bandages, medical science, etc., can solve the problems of loss of antibacterial ability, achieve high antibacterial ability, improve biodegradability, and high water absorption

Pending Publication Date: 2020-07-17
KUNMING YESHUI BIO TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The international application number is PCT/CN2017/080848, which discloses the modification of the amino group of chitosan by adding a-N

Method used

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  • Instant anti-infection wound care hydrogel material as well as preparation method and application thereof
  • Instant anti-infection wound care hydrogel material as well as preparation method and application thereof
  • Instant anti-infection wound care hydrogel material as well as preparation method and application thereof

Examples

Experimental program
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Example Embodiment

[0043] Example one

[0044] The chitosan-polyitaconic acid graft copolymer (CS-PIA) was synthesized with itaconic acid as the superabsorbent monomer and N,N'-methylenebisacrylamide (MBA) as the crosslinking agent.

[0045] Step 1) Dissolve 1 g of chitosan (CS) in a beaker containing 50 ml of deionized water, add 5 ml of acetic acid solution in the beaker, and vigorously stir at room temperature until the gel forms a uniform solution A. Place the beaker in a 60°C water bath and purge the solution with argon for 10 minutes to remove dissolved oxygen in the system.

[0046] Step 2) Add 0.5 g of ammonium persulfate (APS) to the solution A of step 1), and stir the solution for 10 minutes.

[0047] Step 3) Dissolve 1 g of itaconic acid (IA) in 5 ml with a volume ratio of 50:50 NaOH aqueous solution (1 mol / L): ethanol mixture to prepare solution B1.

[0048] Step 4) Add solution B1, 100 mg of N,N'-methylenebisacrylamide (MBA) and 20 ml of deionized water in step 3) to solution A with ammonium...

Example Embodiment

[0055] Example two

[0056] The chitosan-polyacrylic acid graft copolymer (CS-PAA) was synthesized using acrylic acid as the super absorbent component monomer and N,N'-methylenebisacrylamide as the crosslinking agent.

[0057] Step 1) Dissolve 1 g of chitosan (CS) in a beaker containing 50 ml of deionized water, add 5 ml of acetic acid solution in the beaker, and vigorously stir at room temperature until the gel forms a uniform solution A. Place the beaker in a 60°C water bath and purge the solution with argon for 10 minutes to remove dissolved oxygen in the system.

[0058] Step 2) Add 0.5 g of ammonium persulfate (APS) to the solution A of step 1), and stir the solution for 10 minutes.

[0059] Step 3) Dissolve 1g acrylic acid (AA) in 5ml with a volume ratio of 50:50 NaOH aqueous solution (1mol / L): ethanol mixture to prepare solution B2.

[0060] Step 4) Add solution B1, 100 mg of N,N'-methylenebisacrylamide (MBA) and 20 ml of deionized water in step 3) to solution A with ammonium pe...

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Abstract

The invention belongs to the field of medical engineering, and provides an instant anti-infection wound care hydrogel material which is a chitosan-based graft copolymer which is formed by polymerizingchitosan, an acrylic monomer and a cross-linking agent and has a structural formula (I). The material provided by the invention has high water absorbability and antibacterial ability. Chitosan has good antibacterial property, biocompatibility and biodegradability, has amino salt-NH3 + and hydroxyl-OH, and is convenient for graft polymerization of hydrophilic acrylic monomers under mild reaction conditions. In addition, due to the existence of amino, the chitosan-based polymer not only has good water absorption, but also has antibacterial activity.

Description

technical field [0001] The invention belongs to the field of materials and relates to wound care materials, in particular to an instant anti-infection wound care hydrogel material and its preparation method and application. Background technique [0002] Whether it is a war environment or a peaceful era, the treatment and care of wound bleeding and infection are inevitable challenges. In the case of severe blood loss, the basic principle of traditional hemostasis is to use a mechanical method to apply pressure with gauze to stop blood loss. For small wounds, the principle of action of bandages is the same. [0003] Recently, some local hemostatic drugs have been developed for the treatment of severe bleeding and are used in military and civilian emergency treatment. Among them, chitosan-based wound dressings are included. Chitosan is a derivative of natural biological material chitin. As a wound dressing, chitosan has the advantages of biodegradability, biocompatibility, an...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/06C08F222/38C08J3/075C08L51/02
CPCC08F251/00C08J3/075A61L26/008A61L26/0014A61L26/0061A61L26/0066A61L26/0023C08J2351/02A61L2300/232A61L2300/404C08F220/06C08F222/385C08L51/02C08L5/08
Inventor 陆恩扬
Owner KUNMING YESHUI BIO TECH LTD
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