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Logic circuit and device based on DNA strand displacement

A logic circuit and DNA chain technology, applied in the field of DNA information, can solve problems such as low sensitivity and lack, and achieve the effect of improving work efficiency, mutation sensitivity and accuracy

Active Publication Date: 2020-07-17
GUANGZHOU UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current seesaw gate still has at least the following problems: the seesaw gate is essentially a unit step function, with low sensitivity near the threshold and smooth mutation
At present, there is also a lack of a technical solution in the prior art to solve the above problems

Method used

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  • Logic circuit and device based on DNA strand displacement
  • Logic circuit and device based on DNA strand displacement
  • Logic circuit and device based on DNA strand displacement

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Embodiment Construction

[0037] Embodiments of the present application are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary, and are only for explaining the present application, and should not be construed as limiting the present application. For the step numbers in the following embodiments, it is only set for the convenience of illustration and description, and the order between the steps is not limited in any way. The execution order of each step in the embodiments can be adapted according to the understanding of those skilled in the art sexual adjustment.

[0038] In the following description, references to "some embodiments" describe a subset of all possible embodiments, but it is understood that "some embodiments" may be the same subset or a different subset ...

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Abstract

The invention discloses a logic circuit and device based on DNA strand displacement. The circuit comprises an input module used for obtaining an input signal single chain of a first concentration; thestep module is provided with a corresponding preset threshold value and a preset gain ratio, and is used for reacting to generate an output signal single chain with the concentration of the preset gain ratio when the total concentration of the input signal single chain is higher than the preset threshold value; and the output module is used for outputting a 0-1 digital signal according to the total concentration of the output signal single chain. The device comprises the circuit. According to the embodiment of the invention, the method comprises the steps of carrying out the processing, according to the invention, the step module is arranged in the logic circuit, the concentration of the output signal single chain is adjusted based on the corresponding preset threshold and preset gain ratio and the input signal single chain reaction, and the digital signal is finally output, so that the abrupt change sensitivity and accuracy of the circuit can be improved, and the working efficiency of the circuit formed based on the DNA chain can be improved. The method can be widely applied to the technical field of DNA information.

Description

technical field [0001] This application relates to the field of DNA information technology, especially a logic circuit and device based on DNA strand displacement. Background technique [0002] Biomolecular computing refers to a series of methods that use biomolecules to perform calculations at the molecular scale, including molecular computing, membrane computing, and information storage based on bacteriorhodopsin, etc. In recent years, programmable DNA computing has gradually become a hot research direction, and DNA strand displacement technology is an important means to realize DNA computing. DNA strand displacement technology is an isothermal, enzyme-free in vitro DNA amplification technique that is highly selective for sequence recognition. With the help of DNA nanotechnology, DNA strand displacement has been used in the second generation of DNA probes Systematic gene signal detection, and has the potential to be used as an in vivo intelligent molecular system for the ...

Claims

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Application Information

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IPC IPC(8): G06N3/12
CPCG06N3/123Y02D10/00
Inventor 石晓龙张新建
Owner GUANGZHOU UNIVERSITY
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