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Application of durian peel polysaccharide in preparation of immune-enhancing drug

A technology of immune enhancement and durian peel, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., and can solve the problems of relatively few researches on functional activity

Pending Publication Date: 2020-07-24
HENAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Durian peel is the peel of durian, which is a by-product of durian fruit. The current research is mainly on surface chemical action and adsorption function, but there are relatively few studies on its functional activity. For example, Wu Minzhi and others found that durian shell extract has cough, analgesic and Antibacterial effect, the research of Hong Jun et al. shows that the flavonoids extracted from the durian peel have antioxidant and antibacterial activity

Method used

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  • Application of durian peel polysaccharide in preparation of immune-enhancing drug
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  • Application of durian peel polysaccharide in preparation of immune-enhancing drug

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Experimental program
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Effect test

Embodiment

[0016] The durian skin polysaccharide used in the following application test is obtained through the following steps: take 4.2 kg of dry durian skin, soak the dried durian skin with 80% ethanol (soak 3 times in 80% ethanol, soak for 24 hours each time), take out after soaking Add water to the residue and decoct three times (boiling water temperature 80-85°C, decocting for 2 hours for the first time, 1 hour for the second time, and 0.5 hours for the third time). After the decoction is finished, filter, combine the filtrate, concentrate under reduced pressure, add 95% ethanol to the concentrated solution until the final concentration of ethanol is 75%, leave it in the refrigerator overnight (12h), centrifuge, collect the precipitate, and use the Sevage method to remove the precipitate after being dissolved in water. Protein (select the chloroform-n-butanol mixture with a volume ratio of 4:1, and use conventional techniques in the art). Add 95% ethanol to the supernatant to a fin...

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Abstract

The invention discloses application of durian peel polysaccharide in preparation of an immune-enhancing drug. A mouse hypoimmunity model is established by using cyclophosphamide; thymus and spleen indexes of various groups of mice are respectively measured; histopathological change is observed, so that influence of durian peel polysaccharide on immune organs is evaluated; mouse serum is taken andused for measuring the phagocytic activity, the antioxidant stress ability and the cell factor content; mouse spleens are taken; and the contents of interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) are measured. A test result shows that: the durian peel polysaccharide can effectively improve immunosuppression and antioxidant stress caused by cyclophosphamide, and enhance the mouse immunity; it shows that the durian peel polysaccharide can enhance the mouse immunity; and thus, the durian peel polysaccharide is used for preparing the immune-enhancing drug.

Description

technical field [0001] The invention belongs to the technical field of polysaccharide medicines, and in particular relates to the application of durian skin polysaccharides in the preparation of immune-enhancing medicines. Background technique [0002] Durian is the fruit of the evergreen tree durian (Durio zibethinus Murr) belonging to the family Kapokaceae. It is sweet in taste and warm in nature, and its pulp has anti-inflammatory activity. Durian peel is the peel of durian, which is a by-product of durian fruit. The current research is mainly on surface chemical action and adsorption function, but there are relatively few studies on its functional activity. For example, Wu Minzhi and others found that durian shell extract has cough, analgesic and Antibacterial effect, Hong Jun et al.'s research shows that flavonoids extracted from durian peel have antioxidant and antibacterial activity. Early studies by our research group found that durian skin polysaccharides can regul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/185A61P37/04A61P1/00
CPCA61K31/715A61K36/185A61P37/04A61P1/00A61K2236/333A61K2236/331A61K2236/53A61K2236/39
Inventor 康文艺张岩王金梅马常阳刘振花姜慧敏蒋圣军梁琼心
Owner HENAN UNIVERSITY
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