Medicine for preventing/treating type 2 diabetes and application thereof

Abstract

The invention provides a medicine for preventing / treating type 2 diabetes and an application thereof, and active ingredients in the medicine take miR-21 as a target spot and promote miR-21 in a targeted manner. In this way, the pancreas islet function can be promoted, and the purpose of reducing blood sugar is achieved.

Description

technical field [0001] The application relates to the technical field of medicines, in particular to a medicine for preventing / treating type 2 diabetes and its use. Background technique [0002] Diabetes is the third largest non-communicable disease after cardiovascular diseases and tumors. It affects more than 300 million people worldwide. The prevention, diagnosis and treatment of diabetes and its complications are key research and development problems in the field of medicine in various countries around the world. major direction. Currently, about 90% of diabetic patients belong to type 2 diabetes mellitus (T2DM). The abnormality of pancreatic β-cell function is the key factor leading to abnormal glucose tolerance in people with normal glucose metabolism and the development of T2DM in people with abnormal glucose tolerance, and it is also a key factor in the gradual progression and deterioration of T2DM patients. [0003] The current treatment methods for T2DM include: ...

AI Technical Summary

Problems solved by technology

Among them, hypoglycemic drugs include: sulfonylureas, glinides, GLP-1 receptor agonists, DPP-4 inhibitors, biguanides, thiazolidinediones, direct injection of insulin, etc. It is to control the blood sugar level of the patient, and it needs to be used continuously for a long time, which will affect the quality of life of the patient

And the method of controlling blood sugar may cause the release of insulin not controlled by blood sugar, or the release of blood sugar does not conform to the circadian rhythm, etc. The blood sugar of patients often fluctuates greatly, and it is easy to cause major adverse drug reactions such as hypoglycemia syncope.

Metabolic surgery requires multidisciplinary collaboration to manage the whole process before, during, and after surgery. There are individual differences in curative effect and the control of the effectiveness and safety of surgery.

Islet transplantation can delay the patient's dependence on insulin injection, but it cannot fundamentally solve the islet cell antibody, the body's own rejection reaction and the toxic effect of immunosuppressants on the β-cell itself. Low, side effects of immunosuppressants and high cost of transplantation

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