Application of mPGES-2 as drug target for treating and/or preventing diabetes mellitus

A technology for diabetes, type 1 diabetes, applied in the field of biomedicine

Inactive Publication Date: 2020-07-28
XUZHOU MEDICAL UNIV
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However, the current clinical research on the m...

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  • Application of mPGES-2 as drug target for treating and/or preventing diabetes mellitus
  • Application of mPGES-2 as drug target for treating and/or preventing diabetes mellitus
  • Application of mPGES-2 as drug target for treating and/or preventing diabetes mellitus

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Embodiment Construction

[0028] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0029] The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0030] Materials, reagents, etc. used in the following examples, unless otherwise specified, can be obtained from commercial sources, for example:

[0031] Experimental animals: mPGES-2 heterozygous mice used in this example were obtained by Jiangsu Jicui Yaokang Biotechnology Co., Ltd. using Crispr Cas9 technology, and bred at Xuzhou Medical University to obtain mPGES-2 wild-type (WT) mice and mPGES- 2 Knockout (KO) mice. The mouse-derived mPGES-2 overexpression plasmid was purchased from Hanbio Technology Co., Ltd., and was wrapped by adeno-associated virus (AAV). mPGES-2 overexpression control mice (CON) and mPGES-2 overexpression mice (OVER) were adaptively fed by C57BL / 6 mice for one week, and 100 μL of AAV cont...

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Abstract

The invention discloses application of mPGES-2 as a drug target for developing or screening or preparing drugs for treating and/or preventing diabetes mellitus. The invention puts forward that the mPGES-2 is the drug target of the diabetes mellitus for the first time. Experiments show that by knocking out the mPGES-2, blood sugar of normal-diet mice and high-fat-diet mice is remarkably improved, pancreatic proliferation of the mice is remarkably promoted, meanwhile, differentiation of pancreatic beta cells is promoted, and generation of insulin by pancreas islets is promoted, so that glycometabolism of the mice is improved. By virtue of overexpression of the mPGES-2, generation of cAMP of the pancreas islets can be obviously inhibited, so that secretion of the insulin is inhibited. The experiments show that the mPGES-2 is capable of regulating and controlling the blood sugar, can be taken as the target for treating the diabetes mellitus and has important significances to medicinal development, prevention and treatment of the type of diseases.

Description

technical field [0001] The invention relates to a drug target, in particular to the application of mPGES-2 (microsomal prostaglandin E synthase-2) as a drug target for treating and / or preventing diabetes, belonging to biomedical technology field. Background technique [0002] The incidence of diabetes is increasing year by year all over the world, and it is one of the major diseases that endanger human health. Diabetes is a metabolic disease characterized by hyperglycemia. The core link of its pathogenesis is the dysfunction of pancreatic β cells. Improving the function of pancreatic β cells is an important therapeutic strategy for the treatment of diabetes. Clinically, diabetes is mainly divided into two common conditions, type 1 diabetes and type 2 diabetes. Studies have shown that a variety of inflammatory factors are involved in the occurrence and development of type 2 diabetes. However, the current clinical research on the mechanism of diabetes has been in the explora...

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Application Information

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IPC IPC(8): A61K45/00A61P3/10A61P5/48
CPCA61K45/00A61P3/10A61P5/48
Inventor 孙莹万志康蔡杰高航藤田钟丹丹
Owner XUZHOU MEDICAL UNIV
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