Gene chip for predicting RNA virus infected severe case as well as using method and application

A technology of RNA virus and gene chip, which is applied in the field of gene chip for predicting the severity of RNA virus infection, can solve the problem of severe and critical illness without any prediction method, inability to judge individual differences of patients, progressive decrease in peripheral blood lymphocyte count, etc. problem, to achieve the effect of convenient use

Inactive Publication Date: 2020-07-28
山东端泉健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] 1. It is impossible to judge the internal individual differences of patients based on surrounding indications such as age and basic disease history, and the resulting greatly different prognosis after infection;
[0015] 2. There is no way to predict the possibility of severe and critical illness in a small number of young and middle-aged patients
[0019] 3. Peripheral blood lymphocyte count progressively decreased significantly;
[0022] However, the second method also has the following disadvantages: when the above indicators change, the course of the disease often has substantially entered the severe stage, and many cytokines (inflammatory factors) have begun to interact irreversibly at this time, and an inflammatory storm is gaining momentum It is ready to go, and it can often turn into an inflammatory storm within a time window of several hours and then from respiratory distress syndrome to multiple organ failure

Method used

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  • Gene chip for predicting RNA virus infected severe case as well as using method and application
  • Gene chip for predicting RNA virus infected severe case as well as using method and application
  • Gene chip for predicting RNA virus infected severe case as well as using method and application

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Embodiment Construction

[0059] Specific embodiments of the present invention will be described in detail below.

[0060] A gene chip for predicting severe RNA virus infection, said gene chip comprising probes capturing genes shown in Table 1:

[0061] Table 1

[0062] ACE ANGPT2 ASRD CD55 FAAH GLDC IFITM3 IL1A IL1B IL1RN IL6 IL10 IL17 IL28B IRAK3 LGALS1 LRRC16A MBL-2 NAMPT NFE2L2 PI3 POPDC3 PPFIA1 SP-A2 SP-B ST3GAL1 TLR1 TLR3 TMPRSS2 TNFA VEGF XKR3 ACYP2 BCL2L1 CTC1 CXCR4 NFY1 OBFC1 PXR RTEL1 TERC TERT ZNF208 ZNF311 ZNF676

[0063] .

[0064] Further, the RNA viruses include influenza and coronaviruses.

[0065] Further, the gene chip also includes probes for detecting SNP sites, and the SNP sites include: rs1868554, rs2442598, rs78142040, rs2564978, rs324420, rs1755609, rs12252, rs34481144, rs17561, rs1143627, rs16944, rs31365598, 2 rs1818879、rs2069832、rs1800...

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Abstract

The invention discloses a gene chip for predicting RNA virus infected severe case. The gene chip comprises probes for capturing the following genes of ACE, ANGPT2, ASRD, CD55, FAAH, GLDC, IFITM3, IL1A, IL1B, IL1RN, IL6, IL10, IL17, IL28B, IRAK3, LGALS1, LRRC16A, MBL-2, NAMPT, NFE2L2, PI3, POPDC3, PPFIA1, SP-A2, SP-B, ST3GAL1, TLR1, TLR3, TMPRSS2, TNFA, VEGF, XKR3, ACYP2, BCL2L1, CTC1, CXCR4, NFY1,OBFC1, PXR, RTEL1, TERC, TERT, ZNF208, ZNF311, and ZNF676.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a gene chip for predicting severe RNA virus infection and its use method and application. Background technique [0002] RNA virus is a type of virus whose genetic material is ribonucleic acid (RNA ribonucleic acid). Usually the nucleic acid is single-stranded (ssRNA single-stranded RNA), but also double-stranded (dsRNA double-stranded RNA). Single-stranded RNA viruses can be divided into positive-translation, negative-translation and double-translation RNA viruses according to their translation meaning. Positive-translation RNA viruses are similar to mRNA and can be directly translated into proteins by ribosomes; negative-translation RNA viruses require RNA polymerization The role of the enzyme is to use itself as a template to synthesize a self-complementary positive translation RNA, and then use this RNA as mRNA to translate protein. [0003] Plant viruses, with a few e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/70C12Q1/6837C12R1/93
CPCC12Q1/701C12Q1/6837C12Q2600/156
Inventor 陈晓薇李红林
Owner 山东端泉健康科技有限公司
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