Gene chip for predicting RNA virus infected severe case as well as using method and application

Abstract

The invention discloses a gene chip for predicting RNA virus infected severe case. The gene chip comprises probes for capturing the following genes of ACE, ANGPT2, ASRD, CD55, FAAH, GLDC, IFITM3, IL1A, IL1B, IL1RN, IL6, IL10, IL17, IL28B, IRAK3, LGALS1, LRRC16A, MBL-2, NAMPT, NFE2L2, PI3, POPDC3, PPFIA1, SP-A2, SP-B, ST3GAL1, TLR1, TLR3, TMPRSS2, TNFA, VEGF, XKR3, ACYP2, BCL2L1, CTC1, CXCR4, NFY1,OBFC1, PXR, RTEL1, TERC, TERT, ZNF208, ZNF311, and ZNF676.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a gene chip for predicting severe RNA virus infection and its use method and application. Background technique [0002] RNA virus is a type of virus whose genetic material is ribonucleic acid (RNA ribonucleic acid). Usually the nucleic acid is single-stranded (ssRNA single-stranded RNA), but also double-stranded (dsRNA double-stranded RNA). Single-stranded RNA viruses can be divided into positive-translation, negative-translation and double-translation RNA viruses according to their translation meaning. Positive-translation RNA viruses are similar to mRNA and can be directly translated into proteins by ribosomes; negative-translation RNA viruses require RNA polymerization The role of the enzyme is to use itself as a template to synthesize a self-complementary positive translation RNA, and then use this RNA as mRNA to translate protein. [0003] Plant viruses, with a few e...

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Problems solved by technology

[0014] 1. It is impossible to judge the internal individual differences of patients based on surrounding indications such as age and basic disease history, and the resulting greatly different prognosis after infection;

[0015] 2. There is no way to predict the possibility of severe and critical illness in a small number of young and middle-aged patients

[0019] 3. Peripheral blood lymphocyte count progressively decreased significantly;

[0022] However, the second method also has the following disadvantages: when the above indicators change, the course of the disease often has substantially entered the severe stage, and many cytokines (inflammatory factors) have begun to interact irreversibly at this time, and an inflammatory storm is gaining momentum It is ready to go, and it can often turn into an inflammatory storm within a time window of several hours and then from respiratory distress syndrome to multiple organ failure

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