Refining process of 5-methoxy-4, 6-dichloropyrimidine

Abstract

The invention discloses a preparation method of 5-methoxy-4, 5-dimethyl-1, 3-dioxolane. The preparation method comprises the following steps: adding 2 / 3 of methanol into 2-methoxy-malonic acid dicarboxylic acid; dissolving 2-methoxy-malonic acid dicarboxylic acid, adjusting the temperature to -1 DEG C to 0 DEG C, carrying out a reaction for 2-4 h with ammonia gas, filtering, washing with 1 / 3 methanol, and carrying out vacuum drying at 41-45 DEG C to obtain 2-methoxy-malonamide with a yield of 91-93%; heating and stirring sodium ethoxide, 2 / 3 of ethanol and the 2-methoxy-malonamide obtained inthe step 1; during stirring, stirring is conducted for 35-40 min at the temperature of 18-19 DEG C, adding formamide, performing a reflux reaction, adding 1 / 3 of ethyl alcohol for washing after filtering, performing vacuum drying treatment at the temperature of 51-55 DEG C, and obtaining 4, 6-dihydroxy-5-methoxypyrimidine disodium salt, wherein the yield reaches 87-89%. The molding yield of the 5-methoxy-4, 6-dichloropyrimidine preparation is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to a refining process of 5-methoxy-4,6-dichloropyrimidine. Background technique [0002] When the existing 5-methoxy-4,6-dichloropyrimidine is prepared, the molding yield of its raw material preparation is low, which makes the preparation cost higher, and the finished product 5-methoxy-4,6-dichloropyrimidine The use stability of chloropyrimidine is poor, and it has not been well debugged, which is not conducive to the control of personnel preparation in the later stage. Contents of the invention [0003] The object of the present invention is to provide a refining process for 5-methoxy-4,6-dichloropyrimidine to solve the problems raised in the above-mentioned background technology. [0004] In order to achieve the above object, the present invention provides the following technical scheme: the refining process of 5-methoxy-4,6-dichloropyrimidine, including t...

AI Technical Summary

Problems solved by technology

[0002] When the existing 5-methoxy-4,6-dichloropyrimidine is prepared, the molding yield of its raw material preparation is low, which makes the preparation cost higher, and the finished product 5-methoxy-4,6-dichloropyrimidine The use stability of chloropyrimidine is poor, and it has not been well debugged, which is not conducive to the control of personnel preparation in the later stage