SNP molecular marker related to pig feed conversion efficiency

A feed conversion efficiency and molecular marker technology, applied in the field of porcine molecular marker screening, can solve the problems that it is difficult to improve feed efficiency-related traits, feed efficiency cannot be directly measured, etc., and achieve high sensitivity and good specificity

Active Publication Date: 2020-08-07
赤峰家育种业科技有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] In animal breeding programs, it is difficult to improve feed efficiency-related traits by direct selection because feed efficiency cannot be directly measured

Method used

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  • SNP molecular marker related to pig feed conversion efficiency
  • SNP molecular marker related to pig feed conversion efficiency
  • SNP molecular marker related to pig feed conversion efficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Genotyping Detection

[0035] (1) Integrating 16 batches of SNP microarray data from 4005 pigs of four breeds including Large White pig, Landrace pig, Duroc pig and Pietrain pig collected by the laboratory;

[0036] (2) Convert the raw data to Plink format (.ped / .map), and then use Plink software for preliminary quality control (--geno 0.1--maf 0.05--mind 0.1--chr 1-18,X). Use Beagle software to fill the data after the initial quality control, and then use Plink software for the second quality control (--geno 0.1--maf 0.05--mind 0.1), and finally there are 2013 individuals and 46505 SNPs for the whole Genome Association Analysis (GWAS).

Embodiment 2

[0037] Example 2: Application of MARC0045707 molecular marker typing method in pig feed conversion efficiency traits correlation analysis MARC0045707 molecular marker (see sequence listing SEQ ID NO: 1) and pig feed conversion efficiency traits correlation analysis:

[0038] The phenotypes used in the association analysis of genotypes and feed conversion efficiency traits mainly come from data collected in laboratories. Genome-wide association analysis (GWAS) was performed using the FarmCPU model in the rMVP package in the R statistical environment. The FarmCPU model uses a fixed effect model and a random effect model in a cycle. The specific models are as follows: (1) (2)y i = u i +e i , where y i Represents the trait observation value of the i-th individual, is the genotype of t possible association loci added to the model, b 1 , b 2 ,...,b t is the corresponding effect value of the possible association sites added to the model; S ij is the genotype of the jth gen...

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Abstract

The invention belongs to the technical field of pig molecular marker screening, and particularly relates to an SNP molecular marker related to pig feed conversion efficiency. The login number of the SNP molecular marker is MARC0045707, and the SNP chip data of 4005 pigs including the four varieties large white, landrace, Duroc and Pietrain pigs in 16 batches collected in a laboratory are integrated, comparison with a pig reference genome sequence is carried out to obtain genotyping data, a SNP molecular marker related to pig feed conversion efficiency is obtained, the nucleotide sequence of the SNP molecular marker is shown as SEQ ID NO:1, R at the 51st basic group of the sequence is a mutation site, a basic group A is mutated into a basic group G, and the mutation site causes polymorphismof nucleotide of the shown sequence; and when the 51st nucleotide of the sequence shown as SEQ ID NO:1 is G, low pig feed conversion efficiency can be judged.

Description

technical field [0001] The invention relates to the technical field of porcine molecular marker screening, in particular to a SNP molecular marker related to pig feed conversion efficiency and application thereof. The molecular marker of the invention can be used for auxiliary selection and prediction of pig feed conversion efficiency traits. Background technique [0002] Pork is an important meat source for humans, accounting for nearly 40% of the total meat consumed by the world's population. Feed costs account for the highest proportion of total production costs, ranging from 50% to 85% (Young J M, Cai W, Dekkers J CM. Effect of selection for residual feed intake on feeding behavior and daily feed intake patterns in Yorkshire swine[ J]. Journal of Animal Science, 2011, 89(3):639-647.). The key to reducing feed cost is to improve feed conversion ratio (FCR). Improving feed conversion efficiency can not only reduce feed consumption, agricultural costs and energy consumpt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6888C12N15/11G16B20/20
CPCC12Q1/6888C12Q2600/124C12Q2600/156G16B20/20
Inventor 赵书红黄鑫刘小磊李新云尹立林许婧雅项韬马云龙唐振双朱猛进余梅
Owner 赤峰家育种业科技有限公司
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