System for inducing sonoporation of a drug into cancer cells and method thereof

A drug and sound hole technology, applied in the field of systems, can solve problems such as difficult to ensure ultrasound

Active Publication Date: 2020-08-07
FREEDOM WAVES SRL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is even more difficult to ensure that the ultrasonic waves used for sonoporation reach the target cells at the optimal frequency and duty cycle for optimal interaction with the membrane

Method used

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  • System for inducing sonoporation of a drug into cancer cells and method thereof
  • System for inducing sonoporation of a drug into cancer cells and method thereof
  • System for inducing sonoporation of a drug into cancer cells and method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0067] Preferred embodiments of the system of the present invention include:

[0068] - a generator configured to provide electrical energy at an ultrasonic frequency;

[0069] - an ultrasound probe electrically connected to the generator and configured to:

[0070] Converting electrical energy into low-intensity non-focused pulsed ultrasound defined by operating parameters including frequency, duty cycle and operating time of the ultrasound;

[0071] - an input device enabling the operator to enter configuration data including tumor type, drug type, anthropometric values ​​and tumor grade of the patient to which the cancer cell belongs; and

[0072] - a processor configured to:

[0073] Determining values ​​of said operating parameters based on the input configuration data, wherein the value of frequency is determined based on tumor type and anthropometric values, the value of duty cycle is determined based on at least drug type and tumor type; and

[0074] • Controlling t...

Embodiment 1

[0123] In the table below, the percentage of cell death is reported for MCF-7 cells administered with three different concentrations of paclitaxel under three conditions:

[0124] -None-US: the first dose with the first dose of paclitaxel without administration of ultrasound (None-US), followed by the second dose with the second dose of paclitaxel;

[0125] - US-DC = 12%: first dose of paclitaxel with the first dose, pLINFU (with duty cycle = 12%) administered simultaneously for 20 seconds, followed by a second dose of paclitaxel with the second dose, Simultaneously reapply pLINFU for 20 seconds;

[0126] - US-DC = 9%: first dose of paclitaxel with the first dose, pLINFU (with duty cycle = 9%) administered simultaneously for 20 seconds, followed by a second dose of paclitaxel for the second dose, At the same time pLINFU was administered for an additional 20 seconds.

[0127]

[0128] The results of the above table are represented graphically in the Figure 1a middle.

Embodiment 2

[0130] In the table below, the percentage of cell death following administration of three different concentrations of paclitaxel albumin to MCF-7 cells under three conditions is reported:

[0131] -None-US: the first dose with the first dose of paclitaxel albumin, but without administration of ultrasound (None-US), followed by the second dose with the second dose of paclitaxel albumin;

[0132] - US-DC = 12%: 1st dose of paclitaxel albumin for the first dose, concurrently administering pLINFU (with duty cycle = 12%) for 20 seconds, followed by a second dose of paclitaxel albumin Administration for the first time, and pLINFU was administered for 20 seconds at the same time;

[0133] - US-DC=9%: 1st dose of paclitaxel albumin with first dose, pLINFU (with duty cycle = 9%) administered simultaneously for 20 seconds, followed by second dose of paclitaxel albumin The second dose was administered concurrently with pLINFU for an additional 20 seconds.

[0134]

[0135] The resul...

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Abstract

A system for inducing sonoporation of a drug into cancer cells in a tumor and a method thereof are disclosed, the system comprising a generator configured to provide electrical energy at an ultrasoundfrequency; an ultrasound probe electrically connected to the generator and configured to convert the electrical energy into low intensity pulsed ultrasonic waves defined by operation parameters, saidoperation parameters comprising the frequency, the duty cycle, the operation time of the ultrasonic waves; an input device enabling an operator to enter configuration data comprising: type of tumor,type of drug, localization of secondary tumor, anthropometric measurements and grade of tumor; and a processor configured to determine the values of the operation parameters on the basis of the entered configuration data and control the generator and the ultrasound probe to operate according to said determined values, wherein the value of the frequency is determined on the basis of the type of tumor, the localization of the tumor, the grade of tumor and the anthropometric measurements, the value of the duty cycle is determined on the basis of the drug, the type of tumor and the grade of the tumor, and the value of said operation time being determined on the basis of at least the type of tumor and the type of drug.

Description

technical field [0001] The present invention relates to a system for inducing sonoporation of drugs into tumor cancer cells to increase drug uptake by the target (ie tumor). The invention also relates to a method of controlling ultrasound waves in such a way as to induce sonoporation of drugs into cancer cells, thereby improving drug uptake by the target. Background technique [0002] After diseases of the circulatory system, cancer is the second most common cause of death in the world today. The International Agency for Research on Cancer estimates that due to population aging, cancer cases are expected to increase by approximately 21.7 million by 2030, with a death rate of 13 million. Known tumor therapy is based on chemotherapy and / or radiotherapy and / or surgical resection of the tumor mass. Conventional chemotherapy in particular suffers from a lack of selectivity for cancer cells, which can cause side effects at systemic and local levels. In addition, tumors often de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N7/00A61M37/00A61K41/00B06B1/02G16H20/30
CPCA61N7/00A61K41/0047A61M37/0092B06B1/02A61N2007/0078B06B2201/76G16H40/63G16H20/30G16H20/10G16H20/17G16H40/67G16H70/60G16H50/50G16H50/70G16H70/40G16H40/40A61P35/00A61K31/337A61K31/4745A61K31/513A61K31/704A61N2007/0004B06B1/0215B06B2201/55
Inventor P·朱斯泰托D·法莱托
Owner FREEDOM WAVES SRL
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