Antibacterial composition, antibacterial composite nanoparticle, preparation method of antibacterial composite nanoparticle and targeted sustained-release private nanometer gel

A technology of composite nanoparticles and antibacterial composition, applied in the field of personal care, can solve the problems of cell body damage, unfavorable dispersion, use restriction, etc., and achieve the effect of prolonging the action time

Active Publication Date: 2020-08-11
广州睿森生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As a kind of inorganic spectral high-efficiency bactericidal material, nano-silver is non-irritating to human skin, and is widely used in the preparation of women's intimate gel. For example, the Chinese patent whose application number is CN200810016256.6 discloses a chitosan nano-silver gel and Its application uses chitosan nano-silver as an antibacterial product, but because the nano-silver particles themselves are very easy to agglomerate, which is not conducive to dispersion, and has strong permeability, it is easy to enter the cells of various organs of the human body, causing certain damage to the cell body. Therefore, there are certain restrictions on the use of

Method used

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  • Antibacterial composition, antibacterial composite nanoparticle, preparation method of antibacterial composite nanoparticle and targeted sustained-release private nanometer gel
  • Antibacterial composition, antibacterial composite nanoparticle, preparation method of antibacterial composite nanoparticle and targeted sustained-release private nanometer gel
  • Antibacterial composition, antibacterial composite nanoparticle, preparation method of antibacterial composite nanoparticle and targeted sustained-release private nanometer gel

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preparation example Construction

[0030] The present invention also provides a method for preparing antibacterial composite nanoparticles, comprising: S1) mixing the antibacterial composition with water to obtain an antibacterial composition suspension; the antibacterial composition includes Bacillus subtilis fermentation broth, cranberry extract compound and dandelion extract; polylactic acid is mixed with an organic solvent to obtain a polylactic acid organic solution; S2) adding the suspension of the antibacterial composition dropwise to the polylactic acid organic solution, after ultrasonication, centrifugation, and freeze-drying, to obtain an antibacterial composite nanoparticles.

[0031] Among them, the present invention has no special limitation on the sources of all raw materials, which can be commercially available.

[0032] The antibacterial composition is mixed with water to obtain an antibacterial composition suspension; the water is preferably ultrapure water; the ratio of the antibacterial compo...

Embodiment 1

[0047] Example 1: Preparation of polylactic acid-coated antibacterial composite nanoparticles

[0048] Weigh 0.5 mg of Bacillus subtilis fermentation broth, 0.3 mg of cranberry extract, and 0.1 mg of dandelion extract and place them in 1ml of ultrapure water, set the ultrasonic power to 2500W, and the temperature to 30°C for 25 minutes in a water bath to make Its mixed solution is evenly dispersed to form a uniform suspension; 30 mg of polylactic acid (weight average molecular weight 1W, viscosity 0.25dl / g) is weighed and dissolved in 10 ml of acetone to form a polylactic acid acetone solution; the prepared uniform suspension is gradually Add it dropwise into the polylactic acid acetone solution, after ultrasonication for 25min (ultrasonic power is 2500W), then collect it under the centrifugation speed of 2500r / min for 15min, wash with ultrapure water, and freeze-dry to obtain polylactic acid-wrapped antibacterial compound Nanoparticles1.

Embodiment 2

[0049] Example 2: Preparation of polylactic acid-wrapped antibacterial composite nanoparticles

[0050] Weigh 1 mg of Bacillus subtilis fermentation broth, 0.8 mg of cranberry extract, and 0.5 mg of dandelion extract, put them in 2ml of ultrapure water, set the ultrasonic power to 2800W, and set the ultrasonic temperature to 30°C for 27 minutes in a water bath to make it The mixed solution is uniformly dispersed to form a uniform suspension; weigh 40 mg of polylactic acid (weight average molecular weight 1W, viscosity 0.25dl / g) and dissolve it in 15ml with stirring to make a polylactic acid acetone solution, and add the obtained uniform suspension dropwise to In polylactic acid acetone solution, after ultrasonication for 30min (ultrasonic power is 2500W), it is collected under the centrifugal speed of 2800r / min for 15min, washed with ultrapure water, and freeze-dried to obtain polylactic acid-wrapped antibacterial composite nanoparticles 2.

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Abstract

The invention provides an antibacterial composite nanoparticle. The antibacterial composite nanoparticle comprises an antibacterial composition and a polylactic acid coating the outside of the antibacterial composition, wherein the antibacterial composition comprises a bacillus subtilis fermentation liquid, a cranberry extract and a herba taraxaci extract. Compared with the prior art, the antibacterial composite nanoparticle has the advantages that a microbicide and an active nanoparticle are coated with the polylactic acid, so that the antibacterial composite nanoparticle can effectively inhibit and sterilize bacteria, can prolong the action time in a sustained-release manner, reconstructs a vaginal bacteria balance and achieves health maintenance of female vaginas.

Description

technical field [0001] The invention belongs to the technical field of personal care, and in particular relates to an antibacterial composition, an antibacterial composite nanoparticle, a preparation method thereof, and a targeted slow-release nano-private gel. Background technique [0002] With the improvement of living standards, people pay more and more attention to their health, and women's private care has become an important part of personal care. According to the survey results, as many as 91% of women are troubled by private discomforts including unclean secretions, itching, and odors, especially during hot weather, menstruation, prolonged sitting in the office, and before and after intimacy. Human papillomavirus (HPV) infection is the most important factor leading to cervical cancer. At present, the HPV infection rate of women in my country is about 16.8%, and in the healthy female population, the HPV infection rate is generally about 13.5%. Therefore, women should ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/45A61K9/06A61K9/51A61K47/34A61P15/02A61P31/04A61K35/742
CPCA61K36/45A61K36/288A61K35/742A61K9/06A61K9/5153A61K9/0034A61P15/02A61P31/04A61K2300/00
Inventor 孟丽朱军陈凤鸾魏坤王晓慧
Owner 广州睿森生物科技有限公司
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