Method and system for measuring focus drift distance of microscopic image and computer equipment

A technology of microscopic image and drift distance, applied in measurement devices, neural learning methods, instruments, etc., can solve problems such as large errors, and achieve the effects of high speed, strong robustness and high precision

Active Publication Date: 2020-08-18
湖南国科智瞳科技有限公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0006] The invention provides a method, system and computer equipment for measuring the focus drift distance

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  • Method and system for measuring focus drift distance of microscopic image and computer equipment
  • Method and system for measuring focus drift distance of microscopic image and computer equipment
  • Method and system for measuring focus drift distance of microscopic image and computer equipment

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Embodiment Construction

[0028] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

[0029] In addition, the technical solutions between the various embodiments of the present invention can be combined with each other, but they must be based on what can be achieved by those of ordinary skill in the art. When the combination of technical solutions is contradictory or cannot be achieved, it should be considered that the combination of such technical solutions It does not exist and does not fall within the scope of protectio...

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Abstract

The invention discloses a method for measuring the focus drift distance of a microscopic image. The method comprises the following steps: acquiring a microscopic image sequence; calculating a radial average logarithm power spectrum value of each incoherent focus stack image, and obtaining a focusing position of a microscope objective lens according to the radial average logarithm power spectrum value; marking each coherent focus stack image according to the focusing position; dividing the marked coherent focus stack image into a training set and a verification set; training a pre-constructed convolutional neural network model by using the training set, and verifying the trained convolutional neural network model by using the verification set to obtain a trained convolutional neural networkmodel; and measuring the focus drift distance of the microscopic image to be measured by using the trained convolutional neural network model. According to the method provided by the invention, the focus drift distance can be measured only through a single image, the speed is high, the precision is high, and the robustness of the convolutional neural network model is high.

Description

Technical field [0001] The invention relates to the field of microscopic imaging technology, in particular to a method and system for measuring the focus drift distance of a microscopic image, and computer equipment. Background technique [0002] For high-throughput applications of various digital microscopes, maintaining the focus of microscopic images for a long period of time is a critical task. Many biological experiments involve the use of a microscope to perform long-term or large-scale microscopic imaging of the sample, which makes it difficult to focus the sample continuously. [0003] For large-scale microscopic imaging applications, when scanning and stitching multiple microscope fields to form high-content, high-resolution microscopic images, due to changes in sample shape or uneven surface of the stage, it is necessary to adjust each The field of view is refocused to obtain a clear full-field image. [0004] For long-term microscopic imaging applications, when observing...

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Application Information

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IPC IPC(8): G01B11/02G06N3/04G06N3/08
CPCG01B11/02G06N3/08G06N3/045
Inventor 谷秀娟向北海许会
Owner 湖南国科智瞳科技有限公司
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