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A kind of electrolyte powder containing polyethylene glycol and preparation method thereof

A polyethylene glycol and electrolyte technology, applied in the field of medicine, can solve the problems of troublesome use of patients, cumbersome manufacturing process and high manufacturing cost, and achieve the effects of high production efficiency, easy implementation and low cost

Active Publication Date: 2022-05-31
南京金凯木纳米材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned sub-packaging causes cumbersome manufacturing process, high production cost, waste of resources and other problems, and will also bring certain troubles to the use of patients

Method used

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  • A kind of electrolyte powder containing polyethylene glycol and preparation method thereof
  • A kind of electrolyte powder containing polyethylene glycol and preparation method thereof

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preparation example Construction

[0030] According to the method for preparing the electrolyte powder containing polyethylene glycol according to the present invention, the method comprises the following steps:

[0031] (1) pulverize, sieve, and dry polyethylene glycol, polylactic acid, inorganic salts and auxiliary agents respectively; wherein, the D97 particle size of polyethylene glycol after sieving is 160-200 μm, and the D97 particle size of polylactic acid is 160-200 μm. The particle size of D97 is 100~150μm, the particle size of D97 of inorganic salts is 120~160μm, and the particle size of D97 of auxiliary agents is 80~120μm; (2) Weigh the prescribed amounts of polyethylene glycol, polylactic acid, inorganic salts and auxiliary agents. (3) Put the above-mentioned spare materials into the mixer and mix for 30~60min, and take samples to detect the content of the intermediate; (4) After calculating the loading amount according to the intermediate content, divide the package and seal it.

[0032] According ...

Embodiment 1

[0035]Weigh 75000g polyethylene glycol (4000), 15000g polylactic acid, 350g sodium chloride, 350g potassium chloride, 2000g gelatin, 200g cyclamate and 300g lemon essence, crush and sieve to make the D97 particle size meet the requirements, After drying at 40 °C for 1 h, it was used for later use. After mixing the above-mentioned spare materials in a mixer for 30 minutes, take a sample to detect the content of the intermediate. After passing the test, calculate the loading amount according to the intermediate content, and divide it into plastic bottles with scales, add stoppers, and seal with a cap. Among them, each bag contains 75g of polyethylene glycol (4000), 15g of polylactic acid, 0.35g of sodium chloride, 0.35g of potassium chloride, 2g of gelatin, 0.2g of sodium cyclamate and 0.3g of lemon essence.

Embodiment 2

[0037] Weigh 75000g of polyethylene glycol (4000), 10000g of polylactic acid, 350g of sodium chloride, 350g of potassium chloride, 200g of sodium bicarbonate, 3000g of gelatin, 300g of sodium saccharin and 300g of lemon essence, crushed and sieved to make it D97 When the particle size meets the requirements, it is used after drying at 50°C for 1 hour. Put the above-mentioned spare materials in a mixer and mix for 40 minutes, then take samples to detect the content of the intermediates. After passing the test, calculate the filling amount according to the intermediate content, and divide them into plastic bottles with scales, add stoppers, and press the caps to seal. Among them, each bag contains 75g of polyethylene glycol (4000), 10g of polylactic acid, 0.35g of sodium chloride, 0.35g of potassium chloride, 0.2g of sodium bicarbonate, 3g of gelatin, 0.3g of sodium saccharin and 0.3g of lemon flavor.

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Abstract

The invention discloses an electrolyte powder containing polyethylene glycol. The electrolyte powder contains polyethylene glycol, polylactic acid, inorganic salts and auxiliary agents. The content of each component is: polyethylene glycol 70~80%, polylactic acid 10~20%, inorganic salts 0.5~1%, and additives 1~3%. The invention also discloses a preparation method of the polyethylene glycol electrolyte powder. The polyethylene glycol electrolyte powder of the invention has good effect and few adverse reactions, and is suitable for patients. Moreover, the preparation method is simple, the raw materials are easy to obtain, and the cost is low.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a polyethylene glycol-containing electrolyte powder and a preparation method thereof. Background technique [0002] Polyethylene glycol (Polyethylene Glycol, PEG) is a long-chain polymer polymerized by ethylene oxide. If the molecular weight exceeds 3000, it cannot be absorbed in the intestinal tract, and there is a lack of degradation of polyethylene glycol in the intestinal tract. Alcohol (PEG) 4000 enzymes, so it has the effect of laxative and bowel cleansing. The commonly used polyethylene glycols in clinical practice are polyethylene glycol 4000 and 3350. Its mechanism of action is that after entering the body through oral administration, it can form hydrogen bonds with water molecules to retain water in the colon, increase the water content of the feces and soften the feces, restore the volume and weight of the feces to normal, and promote the final completion ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61K9/14A61K47/34A61P1/10A61K31/765A61K33/00A61K33/04
CPCA61K33/14A61K33/04A61K33/00A61K31/765A61K9/146A61P1/10A61K2300/00Y02E60/10
Inventor 李颖杨锋程彦丰杨静宋晓萍
Owner 南京金凯木纳米材料有限公司
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