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Vascular basis-brain connection and cognitive behavior model construction method based on fMRI

A construction method, a technique for blood vessels, applied in the field of model construction of blood vessel basis-brain connection and cognitive behavior

Active Publication Date: 2020-09-08
UNIV OF ELECTRONIC SCI & TECH OF CHINA
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Problems solved by technology

Currently, no studies have directly linked brain function to renal oxygenation and behavioral cognition

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  • Vascular basis-brain connection and cognitive behavior model construction method based on fMRI
  • Vascular basis-brain connection and cognitive behavior model construction method based on fMRI

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Embodiment Construction

[0040] The technical solution of the present invention will be further described below in conjunction with the accompanying drawings.

[0041] Such as figure 1 As shown, a kind of fMRI-based blood vessel foundation of the present invention-brain connection and cognitive behavior model building method, comprises the following steps:

[0042] S1, preprocessing brain fMRI data with SPM12 and NIT; including the following sub-steps:

[0043] S11, removing the fMRI data of the first five time points;

[0044] S12, performing time point correction;

[0045] S13. Perform head movement correction;

[0046] S14. Standardize to the MNI template;

[0047] S15. Regression of 24 head movement parameters, removal of linear trend, white matter and cerebrospinal fluid signals;

[0048] S16, perform bandpass filtering, the frequency band is 0.01-0.1Hz;

[0049] S17. Regression to the mean value of the whole brain.

[0050] S2. Carry out gradient analysis and hierarchical functional connect...

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Abstract

The invention discloses a vascular basis-brain connection and cognitive behavior model construction method based on fMRI. The method comprises the following steps: S1, preprocessing brain function magnetic resonance data by using SPM12 and NIT; S2, finding out a gradient analysis and hierarchical function connection difference brain region as a region of interest, and extracting a gradient value and a hierarchical function connection value corresponding to the region of interest; S3, depicting a vascular aging state by using a kidney medulla R2<*> value; S4, collecting the score of a tested behavior cognition test; S5, performing Pearson's correlation analysis on the functional connection value of the region of interest and indexes for depicting the vascular aging, and performing Pearson'scorrelation analysis on the functional connection value of the region of interest and the score of the behavior cognition test; and S6, carrying out Pearson correlation analysis on the indexes of thevascular aging and the scores of the behavior cognition test. According to the invention, based on functional magnetic resonance, a brain aging research model of vascular basis-brain connection-cognitive behaviors is constructed from the perspective of a hierarchical network, and new evidences are provided for understanding of a brain aging function connection mechanism.

Description

technical field [0001] The invention belongs to the technical field of image processing, and in particular relates to a model building method based on fMRI (functional magnetic resonance imaging)-brain connection and cognitive behavior. Background technique [0002] Functional MRI (fMRI) based on Blood Oxygenation Level-Dependent (BOLD) uses the paramagnetism of deoxygenated hemoglobin and the diamagnetism of oxygenated hemoglobin in blood to evaluate the changes of oxygen content in tissues. It provides a sensitive, non-invasive and reproducible method of detecting oxygen partial pressure in tissue when all other measurement parameters are assumed to be constant. According to the principle of fMRI, fMRI is used to indirectly reflect the spontaneous fluctuation of neuronal signals, but it is also related to oxygen metabolism and blood flow volume and deoxygenated hemoglobin content. Therefore, BOLD-fMRI can reflect the basic changes of oxygen content in tissues and blood ve...

Claims

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Application Information

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IPC IPC(8): A61B5/055A61B5/00G16H30/00G16H50/50
CPCA61B5/0042A61B5/055A61B5/4088A61B5/725A61B2576/026G16H30/00G16H50/50
Inventor 罗程李鹤纯尧德中何满西
Owner UNIV OF ELECTRONIC SCI & TECH OF CHINA
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