Functional antibacterial combined medicine and application

A functional and pharmaceutical technology, applied in the field of medicine, can solve problems such as diverse ingredients, complex preparation process, and unclear interaction of ingredients, and achieve the effect of simple method, high biological safety, and excellent biocompatibility

Pending Publication Date: 2020-09-15
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art also discloses dissolving ultrafiltration-spray drying-molecular dispersion coating-hydration granulation-freeze-drying to produce liposome combination medicine, and provides the molar ratio formula and process of the raw materials of each component of liposome oral preparations , but the preparation process is complicated, the ingredients are diverse, the interaction between the ingredients is not clear, and only known drugs can be used, and the emergence of drug resistance cannot be avoided

Method used

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  • Functional antibacterial combined medicine and application
  • Functional antibacterial combined medicine and application
  • Functional antibacterial combined medicine and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] This example is used to illustrate the preparation method of the functional gold nanoparticles of the present invention.

[0058] Proceed as follows:

[0059] (1) In a round bottom flask, add 0.05 millimoles of chloroauric acid trihydrate (molecular weight 393.83, Sinopharm Chemical Reagent Co., Ltd.) and 30 milligrams of Tween 80 into 10 milliliters of deionized water. Under different reaction conditions (speed: 1000 revolutions per minute, 500 revolutions per minute and 100 revolutions per minute; temperature: 0 degrees Celsius and 25 degrees Celsius), add dropwise 0.05 millimoles of p-aminophenylboronic acid (4ABA molecular weight 136.941, Sigma 1 ml of the aqueous solution of ), the color of the solution in the bottle immediately changed to brown. Keep the reaction conditions for another 2 hours.

[0060] (2) Dialysis the obtained p-aminophenylboronic acid-reduced gold nanoparticles with a dialysis bag (14kDa MW cut-off, Solarbio) for 24 hours to remove untreated chemical...

Embodiment 2

[0063] This example is used to illustrate the preparation method of the functional gold nanoparticles of the present invention.

[0064] Proceed as follows:

[0065] (1) In a round bottom flask, add 0.05 millimoles of chloroauric acid trihydrate (molecular weight: 393.83, Sinopharm Chemical Reagent Co., Ltd.) and 30 milligrams of Tween 80 into 10 milliliters of deionized water. Under different reaction conditions (speed: 1000 revolutions per minute, 500 revolutions per minute and 100 revolutions per minute; temperature: 0 degrees Celsius and 25 degrees Celsius), add 0.05 millimoles of m-aminophenylboronic acid (3ABA molecular weight 136.941, Sigma 1 ml of the aqueous solution of ), the color of the solution in the bottle immediately changed to brown. Keep the reaction conditions for another 2 hours.

[0066] (2) The treatment and particle characterization of the gold nanoparticles reduced by m-aminophenylboronic acid are the same as in Example 1. The results are as follows image 3 ...

Embodiment 3

[0069] This example is used to illustrate the preparation method of the functional gold nanoparticles of the present invention.

[0070] Proceed as follows:

[0071] (1) In a round bottom flask, add 0.05 millimoles of chloroauric acid trihydrate (molecular weight 393.83, Sinopharm Chemical Reagent Co., Ltd.) and 30 milligrams of Tween 80 into 10 milliliters of deionized water. Under different reaction conditions (speed: 1000 revolutions per minute, 500 revolutions per minute and 100 revolutions per minute; temperature: 0 degrees Celsius and 25 degrees Celsius), add dropwise 0.05 millimoles of o-aminophenylboronic acid (2ABA molecular weight 136.941, Sigma 1 ml of the aqueous solution of ), the color of the solution in the bottle immediately changed to brown, and the reaction conditions were maintained for another 2 hours.

[0072] (2) The treatment and particle characterization of the gold nanoparticles reduced by anthranilic acid are the same as in Example 1, and the results are as...

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Abstract

The invention provides a functional antibacterial combined medicine and application thereof. The combined medicine comprises the following two independently existing components: aminophenylboronic acid and chloroauric acid trihydrate; and the combined medicine does not contain a surfactant. Aminophenylboronic acid is a medical intermediate; a method for preparing antibacterial gold nanoparticles by using aminophenylboronic acid as a reducing agent in a synthesis process is simple; bacteria is not easily induced to generate drug resistance; relatively high biological safety is achieved; aminophenylboronic acid modified on the surfaces of the gold nanoparticles changes the permeability of bacterial cell walls through the combination of cis-diol and polysaccharides on the surface of bacteriato cause bacterial death, so that the bacterial targeting is relatively high; aminophenylboronic acid and chloroauric acid are stable and easy to store; the whole preparation process is simple and controllable; the prepared antibacterial gold nanoparticles are good in dispersity; and industrial production can be realized.

Description

Technical field [0001] The invention belongs to the field of medicine, and relates to a functional antibacterial combination medicine with antibacterial effect and applications. Background technique [0002] Many diseases caused by bacterial infections are already one of the biggest health problems in the world, and millions of people die from bacterial infections every year. Both Gram-negative bacteria and Gram-positive bacteria can cause many types of infections. For example, E. coli can cause gastrointestinal and urinary tract infections; Klebsiella pneumoniae can cause liver abscesses; Staphylococcus aureus can cause skin infections. Antibiotics have been widely used to treat various infections since they were first developed in the 1920s. However, the widespread use and abuse of antibiotics quickly led to the emergence of bacterial resistance and caused new social panic. Due to the growth of clinical and market demand, the development of new antibacterial drugs is imminen...

Claims

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Application Information

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IPC IPC(8): A61K33/242A61P31/04A61K31/69
CPCA61K33/24A61K31/69A61P31/04A61K2300/00Y02A50/30
Inventor 蒋兴宇王乐
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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