Application of cordyceps sinensis extract in preparation of immune checkpoint inhibitors

A technology of immune checkpoint and Cordyceps sinensis, which is applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc., to achieve the effect of low cost, high-strength binding ability, and excellent application prospects

Inactive Publication Date: 2020-09-15
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Cordyceps sinensis as a PD-1, PD-L1 or TNFR1 immune checkpoint inhibitor, and the use of Cordyceps sinensis in the treatment of esophageal squamous cell carcinoma, urothelial carcinoma, and squamous non-small cell lung cancer have not been reported

Method used

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  • Application of cordyceps sinensis extract in preparation of immune checkpoint inhibitors
  • Application of cordyceps sinensis extract in preparation of immune checkpoint inhibitors
  • Application of cordyceps sinensis extract in preparation of immune checkpoint inhibitors

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Experimental program
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Embodiment 1

[0040] The preparation of embodiment 1 Cordyceps sinensis extract of the present invention

[0041] 1. Weigh 2g of Cordyceps sinensis powder, use 70% methanol as the solvent, the ratio of solid to liquid is 1:20g / mL, place it at 37°C for ultrasonic extraction 9 times, each time for 30min. Concentrate the extract after suction filtration, and the product number is S1;

[0042] 2. Weigh 1g of Cordyceps sinensis powder, prepare artificial gastric juice and artificial intestinal juice according to "Chinese Pharmacopoeia", use the semi-bionic extraction method, with a material-to-liquid ratio of 1:20g / mL, first add artificial gastric juice and place it at 37°C for ultrasonic extraction for 6 times , 30 min each time, and then add artificial intestinal juice, and then heat and ultrasonically extract at 37°C for 3 times, 30 min each time. Concentrate the extract after suction filtration, and the product number is S2;

[0043] 3. Weigh 1g of Cordyceps sinensis powder, use pure water...

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Abstract

The invention provides application of a cordyceps sinensis extract in preparation of immune checkpoint inhibitors. The immune checkpoint is PD-1, PD-L1 or TNFR1. Experimental results show that the cordyceps sinensis extract provided by the invention has stable and high-strength binding capacity with a plurality of immunomodulatory targets (PD-1, PD-L1 and TNFR1), and can also effectively block binding of 293T-h PD-L1 cells and PD-1 protein. Therefore, the cordyceps sinensis extract disclosed by the invention can be used for preparing immune checkpoint inhibitors including PD-1, PD-L1 and TNFR1, can also be used for preparing various anti-tumor drugs including esophageal squamous cell carcinoma, urothelial carcinoma and squamous non-small cell lung cancer, and has excellent application prospects.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the use of a cordyceps sinensis extract in the preparation of immune checkpoint inhibitors. Background technique [0002] Immunotherapy is an important means of tumor treatment, in which the programmed death receptor 1 (programmed cell death 1, DCD1, PD-1) / programmed cell death ligand 1 (programmed cell death 1 ligand 1, DCD1LG1, PD-L1) pathway Suppressive drugs are currently a hot spot in immunotherapy. PD-1 is an immunosuppressive molecule, which interacts with the ligands PD-L1 and PD-L2, which can lead to the apoptosis of tumor antigen-specific T cells, so that tumor cells escape the body's immune surveillance. PD-L1 belongs to the B7-H1 molecular family, and the expression of PD-L1 can be detected on the surface of many human tumor cells, such as lung cancer, malignant melanoma, breast cancer, gastric cancer, esophageal cancer, pancreatic cancer, renal cell carcinoma, etc. At the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P35/00
CPCA61K36/068A61K2236/331A61K2236/333A61K2236/39A61P35/00
Inventor 邓赟郭大乐曹治兴曹钰镁旷歧轩谭璐张慧敏
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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