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Medical application of compound HSS-8

A compound and medicine technology, applied in the field of medicine application of compound HSS-8

Inactive Publication Date: 2020-09-18
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] There is no report on the activation of CREB by compound HSS-8

Method used

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  • Medical application of compound HSS-8
  • Medical application of compound HSS-8
  • Medical application of compound HSS-8

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Experimental program
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Embodiment Construction

[0021] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0022] 1. Introduction to the experiment:

[0023] The luciferase reporter gene refers to a reporter system that uses luciferin as a substrate to detect firefly luciferase activity. Luciferase can catalyze the oxidation of luciferin to oxyluciferin, and during the oxidation of luciferin, bioluminescence will be emitted. The Luciferase reporter gene system is a reporter system that uses luciferin as a substrate to detect the activity of firefly luciferase (fireflyluciferase). The bioluminescence released during luciferin oxidation can then be measured by a fluorometer, also known as a luminometer or a liquid scintillation meter. Luciferin and luciferase, a bioluminescent system, can detect gene expression extremely sensitively and efficiently. It is a detection method fo...

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Abstract

The invention discloses medical application of a compound HSS-8. The invention discovers that the compound HSS-8 has CREB agonistic activity for the first time and can be used for preparing CREB agonistic drugs. The person skilled in the art knows that CREB are closely related to neuronal protection; CREB plays a key role in development, regeneration, synaptic formation, repair and the like of neurons, and is one of key factors for regulating central nervous system functions; activation of the CREB is associated with promoting learning memory; the activation of CREB is associated with anxietyand depression resistance. Therefore, the compound HSS-8 has the prospects of being developed into neuronal protection, promoting neuronal development, regeneration, synaptic formation and repair, promoting learning and memory and resisting anxiety or depression.

Description

technical field [0001] The invention belongs to the field of medicine and relates to new uses of known compounds, in particular to a medical use of compound HSS-8. Background technique [0002] Compound HSS-8 is an amide compound, and its chemical structural formula is as follows: [0003] [0004] CREB is the abbreviation of cAMP response element binding protein (cAMP response element binding protein), which was discovered in the late 1980s. CREB consists of 341 amino acid residues and has a molecular weight of 43,000. The molecular structure is divided into two regions, the N-terminal region is related to the function of regulating transcription, and the C-terminal region is the site that binds to the promoter. CREB is a regulatory factor in the nucleus, which regulates transcription through autophosphorylation. Studies have found that CREB plays a key role in some neurophysiological activities such as neuron development, regeneration, synapse formation and repair, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61P25/00A61P25/28A61P25/22A61P25/24
CPCA61K31/165A61P25/00A61P25/28A61P25/22A61P25/24
Inventor 王潘谢治深李军张丽萍高改娄勇王梦瑶张振强徐江雁
Owner HENAN UNIV OF CHINESE MEDICINE
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