Quinolinone derivative and preparation method and application thereof

A technology of quinolinone and its derivatives, which is applied in the field of quinolinone derivatives and their preparation, and can solve the problems of less research
CN104447693AActive Publication Date: 2015-03-25SUZHOU HIGHFINE BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU HIGHFINE BIOTECH
Publication Date
2015-03-25

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Abstract

The invention provides a quinolinone derivative as shown in a general formula I and a preparation method thereof, wherein R indicates C1-C4 alkyl. The invention also provides application of the quinolinone derivative as a GPR119 excitant and in preparing a drug for treating diabetes. The compound provided by the invention has certain biological activity and most importantly, the compound provided by the invention is a novel GPR119 excitant with good physicochemical properties.
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Description

technical field

[0001] The invention relates to the field of chemical medicines, and more particularly relates to a quinolinone derivative and its preparation method and application. Background technique

[0002] Diabetes mellitus is a systemic metabolic disorder caused by absolute or relative insufficiency of insulin in the blood and decreased sensitivity of target cells to insulin. It is usually divided into two types: type I and type II. Type II diabetes accounts for more than 90% of all diabetes cases and is a serious progressive disease that causes microvascular complications (including retinopathy, neuropathy and nephropathy) and macrovascular complications (including accelerated arteriosclerosis, coronary heart disease and stroke).

[0003] The treatment of type I diabetes mainly relies on insulin injection, and the development of drugs for type II diabetes is the primary task of overcoming diabetes. Defective islet β-cell function is the main cause of type II diabet...

Claims

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