Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Construction method and application of schizophrenia animal model based on central nervous system myelin function change

A technology of schizophrenia and central nervous system, which is applied in the field of animal model construction of schizophrenia, can solve the problems of complex production process, low repeatability, damage to other glial cells, etc., and achieve the effect of ensuring repeatability

Active Publication Date: 2020-09-25
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the myelin damage effect of CPZ is not specific to oligodendrocytes, and other glial cells will also be damaged; and these models have problems such as relatively complicated production process, long time and low reproducibility

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Construction method and application of schizophrenia animal model based on central nervous system myelin function change
  • Construction method and application of schizophrenia animal model based on central nervous system myelin function change
  • Construction method and application of schizophrenia animal model based on central nervous system myelin function change

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0041] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0042] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a construction method and application of a schizophrenia animal model based on central nervous system myelin function change, and belongs to the technical field of biological medicine. The important effect of oligodendrocyte / myelin dysfunction in incidence of schizophrenia is used as a study breakthrough point, according to the central nervous system oligodendrocyte / myelindysfunction, the behavioral phenotype is similar to the animal behavior of typical schizophrenia, and the schizophrenia animal model is constructed and belongs to a brand-new pathogenesis mechanism for studying schizophrenia. Since animal model construction is derived from mating of genetically modified mice, a large number of model mice can be obtained, and the repeatability between experimentalbatches and the stability of experimental results are ensured. Experimental study on the constructed animal model is carried out through a histological method and a behavioral method, and it is foundthat the animal model can provide an important research basis for comprehensively analyzing and studying the schizophrenia occurrence mechanism and clinical treatment strategies.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a construction method of an animal model, in particular to a construction method and application of an animal model of schizophrenia based on the change of central nervous system myelin sheath function. Background technique [0002] Schizophrenia (SZ) is a serious neurological disorder with a worldwide incidence of about 1% and is hereditary in families. Usually the disease develops from the middle and late stages of adolescence to early adulthood, that is, about 16-30 years old. Clinically, patients with SZ present with positive symptoms, such as hallucinations, delusions, and bizarre behavior, and / or negative symptoms, such as lack of motivation, apathy, attention deficits, and poor language, as well as cognitive impairment. The pathogenesis of SZ is complex and unknown, the recurrence rate after treatment is high, and some patients need to take medicine for life; and there ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A01K67/027C12N15/85
CPCA01K67/0278A01K67/0271C12N15/85A01K2207/15A01K2207/12A01K2217/15A01K2217/206A01K2227/105A01K2267/0318C12N2800/107
Inventor 赵湘辉芦国珍张明武胜昔
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com