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Peptide-containing water-soluble solution and application

A water-soluble, aqueous solution technology, applied in the fields of daily chemicals, cosmetics, and skin care products, can solve the problems of inactivation of peptides, lack of wide applicability, and increase the burden of cosmetic compatibility, etc., and achieve the effect of stable properties

Inactive Publication Date: 2020-09-29
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires the addition of stabilizers and preservatives, which increases the compatibility burden of cosmetics
At the same time, this method solves the problem of compounding sulfhydryl-containing polypeptides and insoluble peptides, which does not have wide applicability
A disclosed composition and its application (patent application number CN 105168014 A) with a powerful function of removing dark circles, 5,7-dihydroxyflavone, peptides (palmitoyl tripeptide, palmitoyl tetrapeptide) ), mixed with emulsifier, heated to 80-90°C, melted and used as an even oil phase, heating up to 80-90°C will easily inactivate the peptide and weaken its efficacy
In addition, the published cosmetic patents for insoluble peptides (patent application publication numbers CN104622779 A, ​​CN 105232352 A, CN 106109302 A) state that physical mixing does not essentially solve the problem of dissolution of insoluble peptides

Method used

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  • Peptide-containing water-soluble solution and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Palmitoyl Hexapeptide-12 / Palmitoyl Tetrapeptide-7 / Copper Peptide Formula:

[0051]

[0052] Preparation method: Weigh a certain amount of palmitoyl hexapeptide-12, palmitoyl tetrapeptide-7 and copper peptide into a pure mortar, grind to a fine powder and transfer the peptides to a clean container. Mix PEG-40, mugwort oil and water evenly to obtain an oil-water mixed solution. Add the oil-water mixture to the above-mentioned peptide powder, continue grinding, and then put the grinding solution in ultrasonic until the solution is transparent. Add olive oil, collagen, glycerin, salicylic acid, turmeric, and water into the peptide solution in sequence according to the above proportions, mix well and then add xanthan gum to adjust the fluidity of the mixed solution. Finally, sodium hydroxide and acetic acid were used to adjust the pH of the mixed solution to 6.5. The mass percent of each component is shown in the table above. After standing still for 1 hour, filter thr...

Embodiment 2

[0054] Palmitoyl Tripeptide-5 / Palmitoyl Tripeptide-1 / Acetyl Hexapeptide-8 / Hexapeptide-9 Formula:

[0055]

[0056] Preparation method: Weigh a certain amount of palmitoyl tripeptide-5, palmitoyl tripeptide-1, acetyl hexapeptide-8, and hexapeptide-9 in a pure mortar, grind to a fine powder, and transfer the peptides into a clean container. Add water to PEG-60 and mix evenly to obtain an aqueous solution. Add this water mixture to the above-mentioned peptide powder, continue grinding, and then put the grinding solution into ultrasonic until the solution is transparent. Add stearic acid, squalene, sorbitan monohydrate laurate, hyaluronic acid, benzyl alcohol, gallic acid, coenzyme Q10, and glycerin into the peptide solution in accordance with the above proportions, mix well and add carbomer , to adjust the flow properties of the mixed solution. Finally, sodium hydroxide and acetic acid were used to adjust the pH of the mixed solution to 6.5. The mass percent of each compon...

Embodiment 3

[0058] Palmitoyl Pentapeptide-4 / Palmitoyl Tripeptide-5 / Acetyl Hexapeptide-8 Formula:

[0059]

[0060] Preparation method: Weigh a certain amount of palmitoyl pentapeptide-4, palmitoyl tripeptide-5, and acetyl hexapeptide-8 in a pure mortar, grind to a fine powder, and transfer the peptides to a clean container. Mix PEG-100 and PEG-40 with water to obtain an aqueous solution. Add this water mixture to the above-mentioned peptide powder, continue grinding, and then put the grinding solution into ultrasonic until the solution is transparent. Add palm wax, quaternary ammonium salt, vitamin B5, vitamin B2, carotene, benzoic acid, and chitin into the peptide solution in sequence according to the above proportions, mix well and then add carbomer to adjust the fluidity of the mixed solution. Finally, sodium hydroxide and acetic acid were used to adjust the pH of the mixed solution to 6.5. The mass percent of each component is shown in the table above. After standing still for 1...

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Abstract

The invention discloses a peptide-containing water-soluble solution and a preparation method thereof. The water-soluble solution comprises hydrogenated castor oil and / or PEG modified hydrogenated castor oil; and peptide comprises one or a mixture of two or more of palmitoyl tripeptide-1 / palmitoyl oligopeptide, palmitoyl tripeptide-5 / collagen peptide, copper peptide / tripeptide-1 copper / prezatide copper acetate, palmitoyl tetrapeptide-7 / palmitoyl tetrapeptide-3, acetyl tetrapeptide-9, acetyl tetrapeptide-5,palmitoyl pentapeptide-4 / M-based peptide, pentapeptide-18, myristoyl pentapeptide-17, palmitoyl hexapeptide / palmitoyl hexapeptide-12, acetyl hexapeptide-8, acetyl octapeptide / acetyl glutamyl heptapeptide-3, hexapeptide-2, hexapeptide-9, hexapeptide-10, acetyl hexapeptide-38, nonapeptide-1and decapeptide-12. The water-soluble solution disclosed by the invention can still be clear and transparent under the high concentration, and no impurity is separated out. The prepared peptide solution is stable in property, mild and non-irritant, and the preparation method is green, controllable and low in consumption. In addition, the water-soluble solution provided by the invention has excellent compatibility, and can be compatible with a variety of humectants, thickeners, functional molecules, plant essences and the like and has wide application prospects in the fields of cosmetics, skincare products, daily use chemicals and the like.

Description

technical field [0001] The present invention relates to the fields of cosmetics, skin care products and daily chemicals, in particular to water-soluble solutions of cosmetic peptides, especially insoluble peptides, and water-soluble solutions and oily base materials, surfactants, moisturizing agents, pigments, preservatives, antibacterial Compatible application of agents, anti-inflammatory agents, penetrating agents, etc. Background technique [0002] my country is the second largest consumer of cosmetics in the world. With the improvement of people's living standards, the market demand for cosmetics with anti-aging, acne-removing, and scar-relieving effects is gradually increasing. For a long time, cosmetics with collagen, plant extracts, vitamins and hyaluronic acid as the main ingredients have been favored by consumers. Such cosmetics have played an important role in moisturizing and anti-inflammatory, but they still cannot deal with the complexities of skin aging. In re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/92A61K8/67A61K8/36A61K8/86A61Q19/00
CPCA61K8/361A61K8/64A61K8/678A61K8/86A61K8/922A61K2800/592A61K2800/5922A61Q19/00
Inventor 闫学海邢蕊蕊宋静文袁成前李淑坤
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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