30 results about "Myristoyl-CoA" patented technology

Compounds, pharmaceuticals, cosmetic or dietary supplements for the treatment of overweight, obesity and/or type II diabetes in a mammal (e.g. human) comprising a compound with formula I or formula II for example ceramidase-inhibitor, such as (1S,2R)-D-erythro-2-(N-myristoylamino)-1- phenyl-1-propanol, alone or in combination with an anorexic lipid (or other appetite-inhibiting acylamides or oleoyl-estrone), and methods of treatment comprising administration of said compounds, pharmaceuticals, cosmetic or a dietary supplements. The compounds, pharmaceuticals, cosmetic or dietary supplements and methods of the invention may further be used in modifying the feeding behaviour, suppression of hunger, enhancement of satiety, reduction of energy intake, reduction of fat tissue mass/lean mass ratio in a mammal (e.g. human).

The invention discloses myristoyl pentapeptide-17 with obvious promotion of eyelash growth and a solid phase synthesis method thereof. The myristoyl pentapeptide-17 with obvious promotion of eyelash growth has an amino acid sequence shown in SEQ ID NO: 1. The crude peptide obtained by the method of the present invention has a high yield of greater than 60% and a high purity of greater than 96%. The problem existing in the prior art is better solved, the myristoyl pentapeptide-17 has the effect of obviously promoting hair growth, and the synthesized myristoyl pentapeptide-17 can be applied to the fields of food, pharmaceutical, cosmetics and the like.

The invention discloses a composition and a preparation for improving human alopecia and hair growth and a preparation method of the composition. The composition is prepared from the following components: 0.05 to 1 part of biotin tripeptide-1, 0.05 to 1 part of myristoyl pentapeptide-17, 0.01 to 1 part of glossy privet fruit extract, 0.01 to 1 part of herba ecliptae extract, 0.01 to 1 part of cortex dictamni extract, 0.01 to 1 part of radix sophorae flavescentis extract and 0.01 to 1 part of cortex mori radicis extract. 0.01 to 1 part of cacumen biotae extract, 0.01 to 1 part of radix polygoni multiflori extract, 0.01 to 1 part of radix angelicae sinensis extract, 0.01 to 1 part of agilawood extract, 0.01 to 1 part of semen nigellae extract and 0.01 to 1 part of holy basil extract. The composition is a traditional Chinese medicine compound and biological polypeptide composition, can improve alopecia and promote blackening and densification of hair, can be applied to anti-alopecia and hair growth products, and comprises shampoo, hair conditioners, hair care essential oil, hair masks, eyebrow and eyelash growth liquid and the like.

The invention discloses a peptide-containing water-soluble solution and a preparation method thereof. The water-soluble solution comprises hydrogenated castor oil and/or PEG modified hydrogenated castor oil; and peptide comprises one or a mixture of two or more of palmitoyl tripeptide-1/palmitoyl oligopeptide, palmitoyl tripeptide-5/collagen peptide, copper peptide/tripeptide-1 copper/prezatide copper acetate, palmitoyl tetrapeptide-7/palmitoyl tetrapeptide-3, acetyl tetrapeptide-9, acetyl tetrapeptide-5,palmitoyl pentapeptide-4/M-based peptide, pentapeptide-18, myristoyl pentapeptide-17, palmitoyl hexapeptide/palmitoyl hexapeptide-12, acetyl hexapeptide-8, acetyl octapeptide/acetyl glutamyl heptapeptide-3, hexapeptide-2, hexapeptide-9, hexapeptide-10, acetyl hexapeptide-38, nonapeptide-1and decapeptide-12. The water-soluble solution disclosed by the invention can still be clear and transparent under the high concentration, and no impurity is separated out. The prepared peptide solution is stable in property, mild and non-irritant, and the preparation method is green, controllable and low in consumption. In addition, the water-soluble solution provided by the invention has excellent compatibility, and can be compatible with a variety of humectants, thickeners, functional molecules, plant essences and the like and has wide application prospects in the fields of cosmetics, skincare products, daily use chemicals and the like.

The invention discloses recombinant escherichia coli for producing L-glutamine and a construction method and application thereof. The invention firstly discloses recombinant Escherichia coli, compared with Escherichia coli serving as a starting strain, the expression quantity and/or content and/or activity of genes of glutamine synthetase are increased, and/or the expression quantity and/or content and/or activity of genes of the following proteins are reduced; the protein is at least one of the following: glutaminase A; glutaminase A and glutaminase B; a difunctional enzyme which has the activity of glutamine synthetase adenine transferase and the activity of glutamine synthetase deadenylation at the same time; a myristoyl carrier protein dependent acyltransferase; and a PII-1 protein. The invention further provides a method of preparing L-glutamine. A set of method for efficiently synthesizing free L-glutamine by taking L-glutamic acid as a substrate is developed by overexpressing a gene of glutamine synthetase in escherichia coli and blocking a bypass pathway.

The invention relates to an anti-hair-loss hair-growing composition and a preparation method thereof. The anti-hair-loss hair-growing composition comprises freeze-dried powder and solvent liquid, wherein the freeze-dried powder comprises water, a freeze-drying protective agent, composite polypeptide and proteins; the solvent liquid comprises water, a solubilizer, a hair growing aid, a preservative and a pH regulator; the composite polypeptide is prepared from acetyl tetrapeptide-3, octapeptide-2, oligopeptide-1, oligopeptide-3, oligopeptide-5, myristoyl pentapeptide-17 and a copper peptide; the proteins are collagen and/or a placenta extract; the hair growth auxiliary agent is prepared from pyrrolidinyl diaminopyrimidine oxide, adenosine and panthenol. The hair loss preventing and hair growing composition can effectively supplement scalp nutritional ingredients, adjust the activity of scalp cells, promote activation of hair follicle stem cells, promote absorption of hair papilla to the nutritional ingredients and stimulate hair follicles in a dormant state for a long time to revive and grow, and then the effects of nourishing hair, fixing hair and promoting hair growth are achieved.

Peptides are provided that comprise less than 24 amino acids. The peptides have an amino acid sequence selected from the group consisting of: (a) an amino acid sequence having from 4 to 23 contiguous amino acids of a reference sequence PEPTIDE 1; (b) an amino acid sequence substantially identical to the sequence defined in (a); and (c) a variant of the amino acid sequence defined in (a). Also provided is a non-myristoylated MANS peptide. Various methods of using the peptides are also provided.

The invention discloses eyelash growth liquid and a preparation method thereof. The eyelash growth liquid comprises a phase A and a phase B, wherein the phase A comprises water, a thickening agent and a first humectant; the phase B comprises a myristoyl pentapeptide-4 mixed solution, a biotin tripeptide-1 mixed solution, a soluble collagen mixed solution, a portulaca oleracea extract mixed solution, an oligopeptide-1 mixed solution, a mixed solution of a bifidus yeast fermentation product lysate and a lactobacillus fermentation product, and a second humectant; a phase C: 0.1-0.3% of a preservative solution; the eyelash growth liquid can effectively grow eyelashes and reduce eyelash shedding, and meanwhile, the eyelash growth liquid is mild in component and obviously reduces irritation. The preparation method of the eyelash growth liquid is simple and convenient in steps and mild in reaction conditions, the phase A, the phase B and the phase C are sequentially added, the temperature needs to be controlled not to exceed 60 DEG C when the phase B and the phase C are added, and the raw material activity is prevented from being affected by high temperature.

The invention discloses a long-chain fatty acid prodrug of N4-hydroxy isopropyl cytidine. The prodrug is freely selected from one of a lauroyl prodrug, a myristoyl prodrug and a palmitoyl prodrug represented by the following structural formula. According to the three prodrugs disclosed by the invention, long-chain alkyl is introduced to hydroxylamine in N4-hydroxy isopropyl cytidine molecules, so that the biological membrane permeability is greatly improved. Moreover, the invention finds that the too long carbon chain easily causes cytotoxicity, and the too short carbon chain cannot achieve the effect of improving the biological homopermeable membrane. In addition, the N4-hydroxycytidine isopropyl ester hydroxylamine structure is easy to oxidize and inactivate in vivo, and the design of a hydroxylamine ester prodrug is beneficial to improving the metabolic stability. Therefore, the compound disclosed by the invention is better in antiviral effect and has a wide application prospect.

The invention discloses a detection reagent preparation and determination method for lipoprotein-associated phospholipase A2, and relates to the field of in-vitro detection reagents, the detection reagent is composed of a reagent R1, a reagent R2 and a reagent R3 which are mutually independently subpackaged, the reagent R1 is a buffer solution with the pH value of 7.6, the reagent R2 is a buffer solution with the pH value of 2.7, and the reagent R3 is a buffer solution with the pH value of 2.7. The reagent R3 is a solution formed by dissolving 1-myristoyl-2-(4-nitrophenyl succinyl)-sn-propyl-3-phosphorylcholine in absolute ethyl alcohol, and the reagent R3 is a solution formed by dissolving 1-myristoyl-2-(4-nitrophenyl succinyl)-sn-propyl-3-phosphorylcholine in The detection reagent disclosed by the invention has the advantages that the detection reagent which is based on a continuous monitoring method and takes the 1-myristoyl-2-(4-nitrophenyl succinyl)-sn-propyl-3-phosphorylcholine as a substrate is provided, and the lipoprotein-related phospholipase A2 in a sample can be rapidly and accurately detected.

The invention belongs to the technical field of daily cosmetics, and relates to amino acid-containing ice crystal cleansing gel, which is prepared from the following components: myristoyl methyl beta-aminopropionic acid, caustic soda liquid, sodium methyl cocoyl taurate, cocamidopropyl betaine, amino acid, auxiliaries and water. The cleansing gel does not contain any dispersing agent, and amino acid serving as ice crystals can be stably suspended in a cleansing product by means of the stabilizing effect of a specific surfactant on the amino acid. It is surprisingly found that the face cleaning product is low in sensitivity to temperature change, and the ice crystal effect and other user experience do not fluctuate and change obviously after the product is subjected to high and low temperature circulation.