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32 results about "Myristoyl-CoA" patented technology

Lipo-Conjugation of Peptides

The present invention provides peptide conjugates that are formed between a modified lipid and a glycosyl residue and / or an amino acid residue on a peptide. The modified lipid includes a modifying group and a lipid linking group. Exemplary lipid linking groups include myristoyl, palmitoyl, and isoprenyl moieties.
Owner:NOVO NORDISK AS

Chiral mesoporous carbon nanometer fiber and preparation method of chiral mesoporous carbon nanometer fiber

The invention belongs to the technical field of materials and discloses chiral mesoporous carbon nanometer fiber and a preparation method of the chiral mesoporous carbon nanometer fiber. The method is characterized in that pyrrole is used as an organic monomer, ammonium persulfate or ferric trichloride is used as oxidants, chiral amphipathic molecule N-myristoyl L-glutamic acid is used as a template, a chiral mesoporous carbon nanometer fiber precursor is synthesized by a chiral template molecule self-assembly induction method, and then, the chiral mesoporous carbon fiber is obtained through high-temperature carbonization in the inert atmosphere. The chiral mesoporous carbon fiber prepared by the method has the uniform and consistent spiral shape, meanwhile, a chiral mesoporous passage exists in the fiber axis center, the mesoporous passage size is 10.7 to 17.7nm, the specific surface area is 38 to 277 m<2> / g, the total pore volume is 0.09 to 0.38 cm<3> / g, in addition, rich nitrogen heteroatom is contained on a fiber wall carbon framework, and the nitrogen element content is 4.6 to 17.5 weight percent.
Owner:SUN YAT SEN UNIV

Combination for promoting eyelash growth

The invention relates to a combination for promoting eyelash growth. The combination comprises myristoyl pentapeptide-4, palmitoyl tripeptide-1 and tripeptide-1 copper. The invention further provides an application of the combination. The combination has the advantages of capabilities of activating keratin gene expression of human bodies to generate more keratin, and promoting eyelash growth. Eyelash growth solution prepared by the combination can promote eyelashes to be long and dense and is mild and non-irritating, functional components can rapidly enter hair follicle and skins and reach skin bottoms to activate dermal papilla cells.
Owner:上海波林丝生物科技有限公司

Method of reducing immunological tolerance to malignancy

Disclosed are therapeutic formulations comprising myristoylCoA and N-myristoyl transferase and methods of using such formulations to stimulate the immune system of a mammal afflicted with carcinoma and having a detectable blood level of unacylated A-protein to produce an immune response thereto. Also disclosed are methods of treating an A-protein displaying carcinoma in a mammal.
Owner:SCHMIDT GEOFFREY J

Inhibitors of anorexic lipid hydrolysis for the treatment of eating disorders

Compounds, pharmaceuticals, cosmetic or dietary supplements for the treatment of overweight, obesity and / or type II diabetes in a mammal (e.g. human) comprising a compound with formula I or formula II for example ceramidase-inhibitor, such as (1S,2R)-D-erythro-2-(N-myristoylamino)-1- phenyl-1-propanol, alone or in combination with an anorexic lipid (or other appetite-inhibiting acylamides or oleoyl-estrone), and methods of treatment comprising administration of said compounds, pharmaceuticals, cosmetic or a dietary supplements. The compounds, pharmaceuticals, cosmetic or dietary supplements and methods of the invention may further be used in modifying the feeding behaviour, suppression of hunger, enhancement of satiety, reduction of energy intake, reduction of fat tissue mass / lean mass ratio in a mammal (e.g. human).
Owner:UNIVERSITY OF COPENHAGEN +1

Tetrahydropyridine derivatives and their use as antibacterial agents

The present disclosure relates to a novel tetrahydropyridine derivative compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, methods for preparing the compounds, methods for inhibiting UDP-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), methods for treating Gram-negative bacterial infections, the use of the compounds for the preparation of therapeutic medicaments for treating Gram-negative bacterial infections, and pharmaceutical compositions for prevention or treatment of Gram-negative bacterial infections, which contain the compounds. The compounds represented by formula I, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure can exhibit excellent effects on the treatment bacterial infections.
Owner:DONG A ST CO LTD

Myristoyl pentapeptide-17 with obvious promotion of eyelash growth and solid phase synthesis method thereof

The invention discloses myristoyl pentapeptide-17 with obvious promotion of eyelash growth and a solid phase synthesis method thereof. The myristoyl pentapeptide-17 with obvious promotion of eyelash growth has an amino acid sequence shown in SEQ ID NO: 1. The crude peptide obtained by the method of the present invention has a high yield of greater than 60% and a high purity of greater than 96%. The problem existing in the prior art is better solved, the myristoyl pentapeptide-17 has the effect of obviously promoting hair growth, and the synthesized myristoyl pentapeptide-17 can be applied to the fields of food, pharmaceutical, cosmetics and the like.
Owner:南京迪维奥医药科技有限公司

Composition and preparation for improving human alopecia and hair growth as well as preparation method and application

PendingCN112870333AImprove clinical symptomsReduce the number of hair lossCosmetic preparationsHair cosmeticsEyelashBiotin
The invention discloses a composition and a preparation for improving human alopecia and hair growth and a preparation method of the composition. The composition is prepared from the following components: 0.05 to 1 part of biotin tripeptide-1, 0.05 to 1 part of myristoyl pentapeptide-17, 0.01 to 1 part of glossy privet fruit extract, 0.01 to 1 part of herba ecliptae extract, 0.01 to 1 part of cortex dictamni extract, 0.01 to 1 part of radix sophorae flavescentis extract and 0.01 to 1 part of cortex mori radicis extract. 0.01 to 1 part of cacumen biotae extract, 0.01 to 1 part of radix polygoni multiflori extract, 0.01 to 1 part of radix angelicae sinensis extract, 0.01 to 1 part of agilawood extract, 0.01 to 1 part of semen nigellae extract and 0.01 to 1 part of holy basil extract. The composition is a traditional Chinese medicine compound and biological polypeptide composition, can improve alopecia and promote blackening and densification of hair, can be applied to anti-alopecia and hair growth products, and comprises shampoo, hair conditioners, hair care essential oil, hair masks, eyebrow and eyelash growth liquid and the like.
Owner:广州诗美化妆品有限公司

Peptide-containing water-soluble solution and application

The invention discloses a peptide-containing water-soluble solution and a preparation method thereof. The water-soluble solution comprises hydrogenated castor oil and / or PEG modified hydrogenated castor oil; and peptide comprises one or a mixture of two or more of palmitoyl tripeptide-1 / palmitoyl oligopeptide, palmitoyl tripeptide-5 / collagen peptide, copper peptide / tripeptide-1 copper / prezatide copper acetate, palmitoyl tetrapeptide-7 / palmitoyl tetrapeptide-3, acetyl tetrapeptide-9, acetyl tetrapeptide-5,palmitoyl pentapeptide-4 / M-based peptide, pentapeptide-18, myristoyl pentapeptide-17, palmitoyl hexapeptide / palmitoyl hexapeptide-12, acetyl hexapeptide-8, acetyl octapeptide / acetyl glutamyl heptapeptide-3, hexapeptide-2, hexapeptide-9, hexapeptide-10, acetyl hexapeptide-38, nonapeptide-1and decapeptide-12. The water-soluble solution disclosed by the invention can still be clear and transparent under the high concentration, and no impurity is separated out. The prepared peptide solution is stable in property, mild and non-irritant, and the preparation method is green, controllable and low in consumption. In addition, the water-soluble solution provided by the invention has excellent compatibility, and can be compatible with a variety of humectants, thickeners, functional molecules, plant essences and the like and has wide application prospects in the fields of cosmetics, skincare products, daily use chemicals and the like.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI

Recombinant escherichia coli for producing L-glutamine and construction method and application thereof

ActiveCN113025542AIncrease productionSingle Reaction System ComponentsBacteriaMicroorganism based processesEscherichia coliAdenylylation
The invention discloses recombinant escherichia coli for producing L-glutamine and a construction method and application thereof. The invention firstly discloses recombinant Escherichia coli, compared with Escherichia coli serving as a starting strain, the expression quantity and / or content and / or activity of genes of glutamine synthetase are increased, and / or the expression quantity and / or content and / or activity of genes of the following proteins are reduced; the protein is at least one of the following: glutaminase A; glutaminase A and glutaminase B; a difunctional enzyme which has the activity of glutamine synthetase adenine transferase and the activity of glutamine synthetase deadenylation at the same time; a myristoyl carrier protein dependent acyltransferase; and a PII-1 protein. The invention further provides a method of preparing L-glutamine. A set of method for efficiently synthesizing free L-glutamine by taking L-glutamic acid as a substrate is developed by overexpressing a gene of glutamine synthetase in escherichia coli and blocking a bypass pathway.
Owner:INST OF MICROBIOLOGY - CHINESE ACAD OF SCI

Cleansing composition

ActiveUS20180000709A1Superior in frothing abilityQuick rinseCosmetic preparationsHair cosmeticsN acylaminoacidSkin texture
Provided is a cleansing composition of acyl amino acid, showing good foamability and good lather retention effect, which is rinsed off quickly and affords superior skin texture after drying. A cleansing composition containing the following components (A), (B) and (C), wherein a weight ratio of (A) / (B) is 0.2-5 and a weight ratio of ((A)+(B)) / (C) is 2.5-10.0:(A) N-lauroylglycine or a salt thereof(B) N-myristoylglycine or a salt thereof(C) N-acyl acidic amino acid having an acyl group having 8-24 carbon atoms, or a salt thereof.
Owner:AJINOMOTO CO INC

Leak hunting agent for an aircraft oxygen system and preparation method thereof

The invention discloses a leak hunting agent for an aircraft oxygen system and a preparation method thereof, and the leak hunting agent for the aircraft oxygen system comprises the following components in percentage by mass: 0.2-0.3% of sodium myristoyl isethionate, 0.05-0.1% of tea saponin, 0.05-0.1% of a foam-stabilizing corrosion-inhibiting auxiliary agent and the balance of deionized water. The foam-stabilizing corrosion-inhibiting auxiliary agent has various functional groups such as alkenyl, acylamino, hydroxyl and =N-O groups, and the acylamino and the =N-O groups have hydrophilicity, so that the foam-stabilizing corrosion-inhibiting auxiliary agent has the foaming and foam-stabilizing effects of a surfactant, and the foam height and durability of the myristoyl sodium isethionate can be enhanced; long-chain alkenyl can be directionally adsorbed to the surface of metal to form a compact adsorption layer to protect the metal from being corroded, and can have a synergistic corrosion inhibition effect with tea saponin; the carbon black is equivalent to N-O to adsorb H+ in an aqueous solution, and part of the carbon black forms quaternary ammonium groups, so that the carbon black has a certain anti-mold effect, and the carbon black and tea saponin have a synergistic antibacterial effect to jointly ensure that a product is not deteriorated; in addition, the buffer effect of stable PH value is achieved.
Owner:广东润和新材料科技有限公司

Hair loss preventing and hair nourishing composition and preparation method thereof

The invention relates to an anti-hair-loss hair-growing composition and a preparation method thereof. The anti-hair-loss hair-growing composition comprises freeze-dried powder and solvent liquid, wherein the freeze-dried powder comprises water, a freeze-drying protective agent, composite polypeptide and proteins; the solvent liquid comprises water, a solubilizer, a hair growing aid, a preservative and a pH regulator; the composite polypeptide is prepared from acetyl tetrapeptide-3, octapeptide-2, oligopeptide-1, oligopeptide-3, oligopeptide-5, myristoyl pentapeptide-17 and a copper peptide; the proteins are collagen and / or a placenta extract; the hair growth auxiliary agent is prepared from pyrrolidinyl diaminopyrimidine oxide, adenosine and panthenol. The hair loss preventing and hair growing composition can effectively supplement scalp nutritional ingredients, adjust the activity of scalp cells, promote activation of hair follicle stem cells, promote absorption of hair papilla to the nutritional ingredients and stimulate hair follicles in a dormant state for a long time to revive and grow, and then the effects of nourishing hair, fixing hair and promoting hair growth are achieved.
Owner:四川暨康生物医药科技有限公司

Proliposome testosterone undecanoate preparation

The present invention relates to a proliposome powder dispersion of testosterone undecanoate (TU) and a phospholipid, comprising a dispersion of TU and dipalmitoyl phosphatidylcholine (DPPC) wherein the weight / weight (w / w) ratio of TU: DPPC in the proliposome powder dispersion is about 1: 2; or TU and dimyristoyl phosphatidylcholine (DMPC), wherein the weight / weight (w / w) ratio of TU: DMPC in the proliposome powder dispersion is about 1: 3; or TU and 1-myristoyl-2-palmitoyl lecithin (MPPC), wherein the weight / weight (w / w) ratio of TU: MPPC in the proliposome powder dispersion is about 1: 3.
Owner:TESORX PHARMA LLC

Eyelash nourishing liquid and preparation method thereof

The invention discloses eyelash nourishing liquid and a preparation method thereof. The eyelash nourishing liquid is prepared from the following components: chondrus crispus, beta-glucan, panthenol, myristoyl pentapeptide-4, palmitoyl tripeptide-1, a radix polygonati officinalis extract, a tremella fuciformis extract, a thickening agent, a humectant and water. The eyelash nourishing liquid disclosed by the invention is prepared from the following components in compatibility: chondrus crispus, beta-glucan, radix polygonati officinalis extract, tremella fuciformis extract, panthenol, myristoyl pentapeptide-4 and palmitoyl tripeptide-1, and the components are mutually synergistic, so that the eyelash nourishing liquid can effectively promote the growth of eyelashes, and the roots of the eyelashes can be more effectively anchored on hair follicles and are not easy to fall off; and the eyelashes are not easy to break, so that the problem that the eyelashes are sparse and short is fundamentally solved, and the eyelashes become slender and dense. According to the preparation method disclosed by the invention, the reaction process and the adding sequence of all the raw materials are strictly controlled according to the characteristics of all the raw material components in the eyelash nourishing liquid, and the eyelash nourishing liquid which is uniform in texture dispersion and good in stability is prepared.
Owner:广州市普高管理咨询有限公司

Mucin hypersecretion inhibitors based on the structure of MANS and methods of use

Peptides are provided that comprise less than 24 amino acids. The peptides have an amino acid sequence selected from the group consisting of: (a) an amino acid sequence having from 4 to 23 contiguous amino acids of a reference sequence PEPTIDE 1; (b) an amino acid sequence substantially identical to the sequence defined in (a); and (c) a variant of the amino acid sequence defined in (a). Also provided is a non-myristoylated MANS peptide. Various methods of using the peptides are also provided.
Owner:BIOMARK PHARMACEUTICALS LTD

A kind of graphene oxide chiral polypyrrole hybrid material, anti-corrosion wave-absorbing coating and preparation method

The invention discloses a graphene oxide chiral polypyrrole hybrid material, an anti-corrosion wave-absorbing coating and a preparation method, comprising the following steps: Step 1: adding N-myristoyl-L-glutamic acid and pyrrole monomer In the solvent, fully disperse and evenly obtain mixed solution A; wherein the mass ratio of N-myristoyl-L-glutamic acid and pyrrole monomer is 1:1~5; step 2: disperse graphene oxide in the solution to form a solution B; step 3: mixed solution A and solution B are fully mixed to form mixed solution C, and the initiator is slowly added dropwise to mixed solution C under stirring conditions; the mass ratio of graphene oxide and pyrrole monomer in mixed solution C 1:20-50; Step 4: After fully reacting, the desired graphene oxide / chiral polypyrrole hybrid material can be obtained after suction filtration, cleaning, drying and grinding; the hybrid material obtained in the present invention has excellent wave-absorbing Performance, but also has good environmental adaptability, that is, anti-corrosion performance.
Owner:SOUTHWEST JIAOTONG UNIV

Amino acid shampoo prepared by compounding biological peptides and herbs and preparation method thereof

The invention relates to an amino acid shampoo prepared by compounding biological peptides and herbs. The amino acid shampoo is prepared from the following raw materials: peptide-myristoyl-hexapeptide-16, glycyl-L-histidyl-L-lysine, cacumen biotae, radix angelicae sinensis, radix polygoni multiflori, water, rhizoma zingiberis, fructus psoraleae, brown sugar, liquorice root, radix angelicae dahuricae, glossy privet fruit, cortex dictamni, cinnabar bark, mulberry leaf, peach kernel, lucid ganoderma, ginseng, yeast powder, lactic acid bacteria powder, white spirit, rosemary essential oil and ginger essential oil. The invention relates to a preparation method of the shampoo. The shampoo finished product is prepared by seven steps: A, weighing Chinese herbal medicines, B, crushing, C, filtering, D, fermenting, E, mixing, F, adding biological peptide, and G, adding essential oil. The shampoo disclosed by the invention is prepared by taking the biological peptide, the peptide-myristoyl-hexapeptide-16 and the glycyl-L-histidyl-L-lysine as auxiliary materials and combining a plurality of traditional Chinese medicines beneficial to hair quality and other ingredients, has good effects of removing dandruff, removing dirt and blackening hair, and can also be used for effectively relieving symptoms of alopecia and premature graying of hair.
Owner:上海百邵生物科技有限公司

Eyelash growth liquid and preparation method thereof

The invention discloses eyelash growth liquid and a preparation method thereof. The eyelash growth liquid comprises a phase A and a phase B, wherein the phase A comprises water, a thickening agent and a first humectant; the phase B comprises a myristoyl pentapeptide-4 mixed solution, a biotin tripeptide-1 mixed solution, a soluble collagen mixed solution, a portulaca oleracea extract mixed solution, an oligopeptide-1 mixed solution, a mixed solution of a bifidus yeast fermentation product lysate and a lactobacillus fermentation product, and a second humectant; a phase C: 0.1-0.3% of a preservative solution; the eyelash growth liquid can effectively grow eyelashes and reduce eyelash shedding, and meanwhile, the eyelash growth liquid is mild in component and obviously reduces irritation. The preparation method of the eyelash growth liquid is simple and convenient in steps and mild in reaction conditions, the phase A, the phase B and the phase C are sequentially added, the temperature needs to be controlled not to exceed 60 DEG C when the phase B and the phase C are added, and the raw material activity is prevented from being affected by high temperature.
Owner:金群

Myristicylation IP enrichment click chemistry kit and use method thereof

The invention discloses a myristicylation IP enrichment click chemistry kit and a use method thereof, and relates to the technical field of protein detection. The kit comprises a first solution, a second solution, a third solution, a fourth solution, a fifth solution and a 50 mM tris (2-carboxyethyl), wherein the first solution is prepared from tetradecanoic acid and dimethyl sulfoxide which are subpackaged and cryopreserved at-20 DEG C; the second solution adopts a lysis solution; the third solution adopts a labeling buffer solution, the fourth solution adopts 10 mM of azido diazo biotin, the fifth solution is prepared from 50 mM of copper sulfate and 0.08-10 ml of water, and the third solution adopts 50 mM of tris (2-carboxyethyl); the sixth solution is composed of phosphine and 2.8665 g-10 ml of water, and the seventh solution is confining liquid. Compared with a common method, the myristoyl IP enrichment click chemical kit has the advantages that more peptide fragments can be enriched, more myristoyl modified proteins can be analyzed, the detail degree and the effect which are better than those of the conventional method can be obtained, and the sensitivity is improved.
Owner:苏州珂茂生物科技有限公司

Fatty acid prodrug of nucleoside-like broad-spectrum antiviral drug as well as preparation method and application of fatty acid prodrug

The invention discloses a long-chain fatty acid prodrug of N4-hydroxy isopropyl cytidine. The prodrug is freely selected from one of a lauroyl prodrug, a myristoyl prodrug and a palmitoyl prodrug represented by the following structural formula. According to the three prodrugs disclosed by the invention, long-chain alkyl is introduced to hydroxylamine in N4-hydroxy isopropyl cytidine molecules, so that the biological membrane permeability is greatly improved. Moreover, the invention finds that the too long carbon chain easily causes cytotoxicity, and the too short carbon chain cannot achieve the effect of improving the biological homopermeable membrane. In addition, the N4-hydroxycytidine isopropyl ester hydroxylamine structure is easy to oxidize and inactivate in vivo, and the design of a hydroxylamine ester prodrug is beneficial to improving the metabolic stability. Therefore, the compound disclosed by the invention is better in antiviral effect and has a wide application prospect.
Owner:ACADEMY OF MILITARY MEDICAL SCI

Detection reagent for lipoprotein-associated phospholipase A2, preparation method and determination method

InactiveCN114397397ADetection activityActivity detectedComponent separationPhospholipaseAlcohol
The invention discloses a detection reagent preparation and determination method for lipoprotein-associated phospholipase A2, and relates to the field of in-vitro detection reagents, the detection reagent is composed of a reagent R1, a reagent R2 and a reagent R3 which are mutually independently subpackaged, the reagent R1 is a buffer solution with the pH value of 7.6, the reagent R2 is a buffer solution with the pH value of 2.7, and the reagent R3 is a buffer solution with the pH value of 2.7. The reagent R3 is a solution formed by dissolving 1-myristoyl-2-(4-nitrophenyl succinyl)-sn-propyl-3-phosphorylcholine in absolute ethyl alcohol, and the reagent R3 is a solution formed by dissolving 1-myristoyl-2-(4-nitrophenyl succinyl)-sn-propyl-3-phosphorylcholine in The detection reagent disclosed by the invention has the advantages that the detection reagent which is based on a continuous monitoring method and takes the 1-myristoyl-2-(4-nitrophenyl succinyl)-sn-propyl-3-phosphorylcholine as a substrate is provided, and the lipoprotein-related phospholipase A2 in a sample can be rapidly and accurately detected.
Owner:深圳市三励方科技有限公司

Polypeptide composition for promoting eyelash growth and application

The invention relates to a polypeptide composition for promoting eyelash growth, which belongs to the field of cosmetics and is characterized by comprising the following active ingredients in percentage by mass: 0.1-2% of eyelash promoting peptide and 0.1-2% of acetyl dipeptide-1 cetyl ester, and corresponding auxiliary materials and auxiliaries. According to the invention, a mixture of biotin tripeptide-1, acetyl tetrapeptide-3 and myristoyl pentapeptide-4 is used as the ciliary promoting peptide, and acetyl dipeptide-1 cetyl ester which only has a relieving effect but does not have a ciliary promoting effect is compounded with the ciliary promoting peptide for use. Under the condition that acetyl dipeptide-1 cetyl ester is compounded with the ciliary promoting peptide, the effect of amplifying the effect of the ciliary promoting peptide is achieved, and the effect of the ciliary promoting peptide in the aspect of promoting eyelash growth is remarkably improved.
Owner:山东科思达美生物科技有限公司

Ice crystal cleansing gel containing amino acid and preparation method of ice crystal cleansing gel

The invention belongs to the technical field of daily cosmetics, and relates to amino acid-containing ice crystal cleansing gel, which is prepared from the following components: myristoyl methyl beta-aminopropionic acid, caustic soda liquid, sodium methyl cocoyl taurate, cocamidopropyl betaine, amino acid, auxiliaries and water. The cleansing gel does not contain any dispersing agent, and amino acid serving as ice crystals can be stably suspended in a cleansing product by means of the stabilizing effect of a specific surfactant on the amino acid. It is surprisingly found that the face cleaning product is low in sensitivity to temperature change, and the ice crystal effect and other user experience do not fluctuate and change obviously after the product is subjected to high and low temperature circulation.
Owner:佛山嘿黑科技有限公司
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