124 results about "Isopentadiene" patented technology

The invention relates to the field of biological engineering and technology, in particular to an enzyme for synthesizing glabridin, a biological synthesis method of glabridin and a bacterial strain. The invention discloses a series of glabridin synthesizing enzymes (phenylalanine ammonialyase, cinnamic acid-4-hydrogenase, tyrosine ammonialyase, p-coumaric acid coenzyme A ligase, chalcone synthase, chalcone reductase, chalcone isomerase, isoflavone synthase, 2-hydroxyisoflavone dehydratase, 4 '-oxymethyltransferase, 4'-hydroxymethyltransferase and 4 '-hydroxymethyltransferase) derived from glycyrrhiza glabra for the first time. ) can be used in the preparation of a compound (e.g., isoflavone 2 '-hydrogenase, isoflavone reductase, Vissisoketoreductase, isoprenyltransferase, pterocarpin reductase, oxidative cyclase, demethylase, cytochrome P450 reductase, and the like). The de novo synthesis of the glabridin in a microbial cell factory is realized for the first time, and the application prospect of the glabridin biological manufacturing industry is greatly promoted.

To provide a thermosetting adhesive composition which has, after thermally cured, a low dielectric constant, a low dielectric loss tangent, a low temperature change rate of the dielectric loss tangent, and good bending resistance.SOLUTION: A thermosetting adhesive composition for bonding between substrates is provided, containing with respect to 100 pts.mass of the total of the thermosetting adhesive composition, 65 to 90 pts.mass of a styrenic elastomer, as crosslinking components, 5 to 20 pts.mass of (A) a modified polyphenylene ether resin having a radical polymerizable group at a molecular terminal, 4 to 10 pts.mass of (B) polybutadiene and / or polyisoprene having a weight average molecular weight of 10,000 to 50,000, a radical polymerization initiator, and an epoxy resin, wherein the total of the contents of the radical polymerization initiator, the epoxy resin and the epoxy resin curing agent is 10 pts.mass or less, a styrenic elastomer having a styrene ratio of less than 67% is contained as the styrenic elastomer, and the total of the content of the component (A) and the content of the component (B) is 25 pts.mass or less.SELECTED DRAWING: Figure 1

The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.

This invention discloses a lubricating grease composition, belonging to the field of lubricating grease technology. The lubricating grease is made from the following raw materials in parts by weight: 20-40 parts base oil, 10-35 parts liquid polybutadiene, 10-30 parts liquid polyisoprene, 10-30 parts liquid styrene-isoprene polymer, 4-15 parts thickener, 0.1-2 parts antioxidant, 0.1-1.5 parts rust inhibitor, and 0.5-3.2 parts extreme pressure anti-wear agent. The lubricating grease of this invention retains the basic properties of lubricating grease while ensuring high viscosity and high adhesion, as well as low-temperature fluidity. Even in a low-temperature environment of -60°C, it can ensure low-temperature start-up, low operating torque, low-temperature pumpability, and fluidity.

Disclosed herein are prenylated flavone compounds having the structure of Formula (I), or a pharmaceutically acceptable salt and / or hydrate or solvate thereof. Also disclosed herein are methods for producing prenylated flavone compounds, and uses for such compounds, including in medical treatments.

The invention is related to a process for synthesizing a sustainable aviation fuel composition. The process comprises providing a reaction mixture comprising a first compound that is at least one of mevalonolactone, mevalonic acid, mevalonate salt, dehydromevalonic acid, dehydromevalonate salt, dehydromevalonolactone or combinations thereof. The process then involves converting the first compound in the reaction mixture to provide a first intermediate comprising isoprene. Then, the isoprene in the first intermediate is reacted in the presence of a first heat transfer agent to provide a second intermediate comprising terpenes. Finally, the second intermediate is allowed to react in the presence of a second heat transfer agent, or alternatively in neat conditions, and optionally in presence of a catalyst to provide the sustainable fuel composition. The sustainable aviation fuel composition made available from the process of the invention is found to comprise monocyclic aromatic hydrocarbons (MAHs) at useful concentration ranges (along with cycloalkanes) while they are substantially devoid of Polycyclic aromatic hydrocarbons (PAHs).

The invention relates to the field of molecular biology, in particular to an enzyme for cannabinoid synthesis and a method for preparing cannabinoid. More specifically, the present invention relates to a method for producing a cannabinoid phenolic acid (CBGA) or an analog thereof, the method comprising the steps of: reacting a heterologous expressed isoprenyltransferase with a geranyl diphosphate (GPP) and an acid; wherein the amino acid sequence of the isoprenyltransferase is SEQ ID No: 1, or the isoprenyltransferase is expressed by the nucleotide sequence of SEQ ID No: 2.

There is provided a recombinant cell comprising a plasmid expressing terpenoid synthase gene and one or more modification to the gene of the recombinant cell. Also provided is a recombinant cell for use in biosynthesis and a method of producing isoprenoid / terpenoid.

System and processes are provided for converting glycerol to acrolein, an aldehyde to isoprene, and one or more fusel oils to isoprene. Each of this processes utilize at least one catalyst that includes a zeolite and one or more metals dopants (e.g., Group 1A metal(s), Group 2A metals(s), or any combination thereof). The at least one catalyst can optionally include one or more non-metal dopants (e.g., boron, phosphor, or a combination thereof).

The invention discloses a regulator for improving grape fruit fragrance and a preparation method thereof, and belongs to the technical field of grape cultivation, each liter of regulator comprises 50 mg-120 mg of chitosan oligosaccharide, 20 mg-50 mg of sodium selenite, 10 mg-20 mg of jasmonic acid methyl ester, 100 mg-250 mg of green tea polyphenol, 10 mg-20 mg of trehalose, 1 mL-5 mL of thymol nanoemulsion, 10 mg-20 mg of beta-cyclodextrin and 0.8 g-1. 0 g of ethyl alcohol, and water is used as a solvent. The content of strawberry ketone, ester and norisoprene compounds in the fruits to which the regulator is applied is obviously increased, nerol and beta-ionone are detected, and the variety of terpene aroma substances is enriched; after the fruit is stored in a high-temperature and high-humidity environment for 3 days, the aroma component change of the fruit to which the regulator is applied is relatively insignificant, and the aroma of the fruit is more stable than that of a reference substance and a blank reference substance.

Phytol (PHY) is a metabolite of plant chlorophyll, is wide in source and is a chain-like diterpenoid substance consisting of four isoprene units, and the phytol ingested by animals is subjected to oxidative metabolism in vivo, so that not only can energy be provided for the animals, but also the growth of the animals can be promoted, and the growth of the animals can be promoted. Moreover, the phytol and the phytanic acid metabolite of the phytol can also be used as signal molecules to participate in glycolipid metabolism and adipocyte differentiation regulation processes, but people cannot directly take the phytol and the phytanic acid from the nature. The effect of phytol in the generation and development of tumors still has huge unknown property. According to the research, the influence of the phytol and the derivative thereof on the growth of colon cancer, breast cancer and melanoma is detected through an in-vitro experiment CCK-8 (Cell Count Kit 8) and an in-vivo experiment such as a mouse subcutaneous tumor model, and the phytol and the derivative thereof are found to be capable of remarkably inhibiting the growth of colon cancer, breast cancer and melanoma and have no obvious toxic and side effects on heart, liver and kidney functions.

To provide a pressure-sensitive adhesive composition for a decorative sheet, which is excellent in adhesion to a low-polarity adherend, heat-resistant adhesion, heat-resistant holding power, and transparency / moldability (coating appearance after molding) in decoration of a molded article, and to provide a decorative sheet and a decorative structure.SOLUTION: The problem is solved by a pressure-sensitive adhesive composition for a decorative sheet containing a block copolymer (A) and a tackifier resin (B), the pressure-sensitive adhesive composition containing a styrene-based elastomer (a- 1) having a soft block composed of at least one of polybutadiene and polyisoprene and a hard block composed of a polymer of a vinyl aromatic compound, and the tackifier resin (B) having a softening point of 125 to 200 °C.SELECTED DRAWING: None

The purpose of the present invention is to provide a method for producing ambrein by which ambrein can be easily and efficiently obtained.　This problem can be solved by a mutant tetraprenyl-β-curcumene cyclase in which aspartic acid that is the fourth amino acid residue of a DXDD motif is substituted by an amino acid other than aspartic acid and the seventh amino acid of a (D / N)G(T / L)(L / F / Y)(Y / F)SY motif is substituted by an amino acid other than tyrosine, said mutant tetraprenyl-β-curcumene cyclase: (a) having nine specific motifs; (b) having 40% or higher sequence identity with the amino acid sequence represented by SEQ ID NO: 1; and (c) showing an ambrein synthesis activity using 8α-hydroxypolypoda-13,17,21-triene as a substrate.

The present application relates to a kind of palladium catalytic ligand regulated azlactone retroisoprenylation method. Specifically, azlactone compound and isoprene react under the action of zero-valent palladium catalyst and monophosphine ligand, and retroisoprenylation product is obtained. A series of azlactone retroisoprenylation derivatives are obtained by simple and safe steps in the present application.

A genetically engineered microbe capable of producing isoprene from glycerol includes at least a native nucleic acid sequence encoding at least a native enzyme capable of catalyzing one or more steps of a conversion from at least a carbon source to acetyl coenzyme A (A-CoA), at least a first heterologous nucleic acid sequence encoding at least a first enzyme of a mevalonate (MVA) pathway, and at least a second heterologous nucleic acid sequence encoding at least a second enzyme capable of catalyzing at least a terpene-producing chemical reaction, wherein the at least a carbon source includes glycerol.

The present invention is related to fermentative production of isoprenoids, comprising cultivation of a suitable host cell, such as fungal host cell, particularly oleaginous host cell, in an improved two-phase culture system.

The invention relates to a strain for degrading beta-carotene, a crude enzyme solution, dioxygenase and application, and relates to the technical field of genetic engineering and microbial fermentation. The invention relates to a strain for degrading beta-carotene, the preservation name of the strain is Escherichia coli LZU-E1, and the strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) with the preservation number of CGMCC No.34862. The invention further discloses a preparation method of the strain for degrading beta-carotene. The method comprises the following steps: screening a strain for efficiently degrading beta-carotene, extracting a crude enzyme solution, researching the enzymatic property of the crude enzyme solution, and mining a new dioxygenase gene for degrading beta-carotene from genome information of the strain by utilizing a molecular biology means, so that the isoprene-reduced natural perfume is efficiently obtained.

The invention relates to a method for synthesizing trans-isopentenyl substituted indolone under the catalysis of transition metal nickel. Specifically, a metal nickel catalyst (Ni (cod) 2) and tricyclohexylphosphine (PCy3) are used as ligands, C3 unsubstituted indolone is used as a nucleophilic reagent to react with isoprene, and a trans-isopentenyl substituted indolone product is obtained. And then taking the product as a reaction raw material, and carrying out nucleophilic substitution reaction on the product and halogenated alkane under an alkaline condition to obtain the 3, 3-disubstituted indolone with divergent functional groups. According to the invention, isoprene is used as a reaction precursor, a trans-isopentenyl substituted indolone product is obtained with high activity and selectivity, a nucleophilic substitution reaction is relayed, and a new strategy is provided for flexibly and conveniently introducing functional groups with different steric hindrances and electrical properties.

Described is a method for the production of isobutene from a carbon source characterized in that it comprises: (a) culturing a microorganism capable of producing 3-methylcrotonic acid from a carbon source in a liquid culture medium, thereby producing 3-methylcrotonic acid so that it accumulates in the liquid culture medium; and (b) enzymatically converting 3-methylcrotonic acid contained in the liquid culture medium obtained in step (a) into isobutene by: (i) incubating a microorganism expressing ap FMN-dependent decarboxylase associated with an FMN prenyl transferase with liquid culture medium containing 3-methylcrotonic acid obtained in step (a); and / or (ii) incubating a FMN-dependent decarboxylase associated with a FMN prenyl transferase with liquid culture medium containing 3-methylcrotonic acid obtained in step (a); thereby producing isobutene; and (c) recovering the produced isobutene.

This invention relates to a method for synthesizing aromatic carbon-10 sulfur-containing compounds from isoprene. Specifically, using disulfide, isoprene, and 2-methyl-1-buten-3-yne as raw materials, aromatic carbon-10 sulfur-containing compounds are constructed under cobalt catalyst and iodine tandem catalysis. This invention has the following advantages: the raw materials are simple and readily available, the synthesis is simple, it is environmentally friendly, the conditions are mild, and it has high atom economy. The compounds obtained from the bulk chemical isoprene have structures similar to natural terpenes and represent an important class of terpenes.

The invention relates to a high cis-1, 4 block copolymer of polybutadiene and polyisoprene and a preparation method of the high cis-1, 4 block copolymer. The present invention provides a vulcanizable composition comprising a rubber component, a filler, and a curing agent wherein the rubber component comprises a block copolymer of polybutadiene and polyisoprene, and wherein the block copolymer has a cis content of at least 90%.

This invention relates to the synthesis of carboxyl-terminated diunsaturated ketones with C=C double bonds at the α,β and γ,δ positions relative to the carbonyl carbon atom, or the β,γ and γ,δ positions. These ketones can be readily obtained from corresponding alkynyl alcohols with terminal carboxyl groups in a few steps. These ketones are important key building blocks for the synthesis of isoprene-like derivatives, especially vitamin E derivatives.

A process for the preparation of isoprenol comprises the steps of a-i) preparing isobutylene by oxidizing isoamyl alcohol to isovaleric acid, and subjecting the isovaleric acid to oxidative decarboxylation so as to obtain isobutylene; and a-ii) reacting at least one formaldehyde source and the isobutylene obtained in step a-i) to obtain isoprenol. The process allows for providing isobutylene for the preparation of isoprenol and its downstream products, including prenol, prenal, isoprenal and / or 3,7-dimethyl-octa-2,6-dienal (citral), from renewable sources.

The invention belongs to the technical field of medicines, and particularly relates to a high-stability flurbiprofen anti-inflammatory patch and a preparation method thereof. A medicine storage adhesive layer of the high-stability flurbiprofen anti-inflammatory patch is prepared from the following raw materials in percentage by mass: 2 to 3 percent of flurbiprofen, 25 to 35 percent of a first adhesive, 6 to 20 percent of a second adhesive, 2 to 3 percent of menthol, 5 to 15 percent of a tackifier, 40 to 55 percent of a plasticizer, 0.1 to 1 percent of an antioxidant and 0.1 to 2.0 percent of an esterification inhibitor; the first adhesive is a maleic anhydride grafted styrene-isoprene-styrene block copolymer; the second adhesive is a maleic anhydride grafted styrene-isoprene-styrene block copolymer; and the second adhesive is a mixture of high-molecular polyisobutene and low-molecular polyisobutene. The auxiliary materials in the patch can effectively inhibit the reaction of the main drug and the penetration enhancer, the stability and curative effect of the product are improved, and meanwhile, the patch has good drug release property and transdermal property.

This invention discloses a chiral oxazoline-pyridine-imine cobalt compound, its synthesis method, and its applications. The synthesis method involves the condensation reaction of 2-cyano-6-acetylpyridine and an aniline derivative with p-toluenesulfonic acid to generate a pyridine-imine compound. This compound is then cyclized with different chiral amino alcohols in the presence of zinc trifluoromethanesulfonate to generate chiral oxazoline-pyridine-imine ligands. The reaction of these ligands with anhydrous cobalt chloride successfully prepared four chiral oxazoline-pyridine-imine cobalt compounds. The cobalt catalyst synthesized in this invention possesses different chiral groups, electronic effects, and steric hindrance, and can catalyze the polymerization of isoprene.

The invention provides a preparation method of a natural product indole alkaloid TMC-205, which comprises the following steps: introducing-COCF3 to the 3-site of indole, hydrolyzing-COCF3 to generate TMC-205 or introducing-CHO to the 3-site of indole, and then introducing-CHO to the 3-site to carry out two lines of Pinnick oxidation to generate TMC-205, by establishing an intermediate, the selectivity is high, the side reaction is extremely few, the problem of low yield caused by direct introduction of carboxyl is solved, and the preparation method is suitable for industrial production. According to the present invention, the method can achieve the quantitative and efficient conversion into the carboxyl group, the use of the high toxicity, the high flammability and the expensive reagent in the traditional method is avoided, and in the key step of constructing the core isoprene structure, the 6-bromoindole with the simple structure is innovatively adopted to directly carry out the Heck-dehydration reaction, such that the potential side reaction is effectively reduced, and the cost is reduced; therefore, the product yield is remarkably improved, and the method is suitable for industrial large-scale production.

A genetically engineered microbe capable of producing isoprene from a carbon source and method related thereto include a first nucleic acid sequence encoding a first enzyme, wherein the first enzyme is configured to catalyze one or more steps of a conversion from the carbon source to acetyl coenzyme A (A-CoA), a second nucleic acid sequence encoding a second enzyme of a mevalonate (MVA) pathway, and a heterologous nucleic acid sequence encoding a third enzyme, wherein the third enzyme is configured to catalyzing an isoprene-producing chemical reaction.

Vulcanizate obtained by sulfur vulcanization of a sulfur-crosslinkable rubber mixture containing - 10 to 30 phr of at least one natural and / or synthetic polyisoprene and - 70 to 90 phr of at least one styrene-butadiene rubber and / or polybutadiene and - at least one polyethylene with a density according to ASTM D 1505 of 0.915 to 0.935 g / cm 3 and a weight average molecular weight distribution Mw according to GPC of 20000 to 500000 g / mol.