83 results about "Isopentadiene" patented technology

The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.

This invention discloses a lubricating grease composition, belonging to the field of lubricating grease technology. The lubricating grease is made from the following raw materials in parts by weight: 20-40 parts base oil, 10-35 parts liquid polybutadiene, 10-30 parts liquid polyisoprene, 10-30 parts liquid styrene-isoprene polymer, 4-15 parts thickener, 0.1-2 parts antioxidant, 0.1-1.5 parts rust inhibitor, and 0.5-3.2 parts extreme pressure anti-wear agent. The lubricating grease of this invention retains the basic properties of lubricating grease while ensuring high viscosity and high adhesion, as well as low-temperature fluidity. Even in a low-temperature environment of -60°C, it can ensure low-temperature start-up, low operating torque, low-temperature pumpability, and fluidity.

Disclosed herein are prenylated flavone compounds having the structure of Formula (I), or a pharmaceutically acceptable salt and / or hydrate or solvate thereof. Also disclosed herein are methods for producing prenylated flavone compounds, and uses for such compounds, including in medical treatments.

The invention is related to a process for synthesizing a sustainable aviation fuel composition. The process comprises providing a reaction mixture comprising a first compound that is at least one of mevalonolactone, mevalonic acid, mevalonate salt, dehydromevalonic acid, dehydromevalonate salt, dehydromevalonolactone or combinations thereof. The process then involves converting the first compound in the reaction mixture to provide a first intermediate comprising isoprene. Then, the isoprene in the first intermediate is reacted in the presence of a first heat transfer agent to provide a second intermediate comprising terpenes. Finally, the second intermediate is allowed to react in the presence of a second heat transfer agent, or alternatively in neat conditions, and optionally in presence of a catalyst to provide the sustainable fuel composition. The sustainable aviation fuel composition made available from the process of the invention is found to comprise monocyclic aromatic hydrocarbons (MAHs) at useful concentration ranges (along with cycloalkanes) while they are substantially devoid of Polycyclic aromatic hydrocarbons (PAHs).

There is provided a recombinant cell comprising a plasmid expressing terpenoid synthase gene and one or more modification to the gene of the recombinant cell. Also provided is a recombinant cell for use in biosynthesis and a method of producing isoprenoid / terpenoid.

Phytol (PHY) is a metabolite of plant chlorophyll, is wide in source and is a chain-like diterpenoid substance consisting of four isoprene units, and the phytol ingested by animals is subjected to oxidative metabolism in vivo, so that not only can energy be provided for the animals, but also the growth of the animals can be promoted, and the growth of the animals can be promoted. Moreover, the phytol and the phytanic acid metabolite of the phytol can also be used as signal molecules to participate in glycolipid metabolism and adipocyte differentiation regulation processes, but people cannot directly take the phytol and the phytanic acid from the nature. The effect of phytol in the generation and development of tumors still has huge unknown property. According to the research, the influence of the phytol and the derivative thereof on the growth of colon cancer, breast cancer and melanoma is detected through an in-vitro experiment CCK-8 (Cell Count Kit 8) and an in-vivo experiment such as a mouse subcutaneous tumor model, and the phytol and the derivative thereof are found to be capable of remarkably inhibiting the growth of colon cancer, breast cancer and melanoma and have no obvious toxic and side effects on heart, liver and kidney functions.

To provide a pressure-sensitive adhesive composition for a decorative sheet, which is excellent in adhesion to a low-polarity adherend, heat-resistant adhesion, heat-resistant holding power, and transparency / moldability (coating appearance after molding) in decoration of a molded article, and to provide a decorative sheet and a decorative structure.SOLUTION: The problem is solved by a pressure-sensitive adhesive composition for a decorative sheet containing a block copolymer (A) and a tackifier resin (B), the pressure-sensitive adhesive composition containing a styrene-based elastomer (a- 1) having a soft block composed of at least one of polybutadiene and polyisoprene and a hard block composed of a polymer of a vinyl aromatic compound, and the tackifier resin (B) having a softening point of 125 to 200 °C.SELECTED DRAWING: None

The purpose of the present invention is to provide a method for producing ambrein by which ambrein can be easily and efficiently obtained.　This problem can be solved by a mutant tetraprenyl-β-curcumene cyclase in which aspartic acid that is the fourth amino acid residue of a DXDD motif is substituted by an amino acid other than aspartic acid and the seventh amino acid of a (D / N)G(T / L)(L / F / Y)(Y / F)SY motif is substituted by an amino acid other than tyrosine, said mutant tetraprenyl-β-curcumene cyclase: (a) having nine specific motifs; (b) having 40% or higher sequence identity with the amino acid sequence represented by SEQ ID NO: 1; and (c) showing an ambrein synthesis activity using 8α-hydroxypolypoda-13,17,21-triene as a substrate.

The present application relates to a kind of palladium catalytic ligand regulated azlactone retroisoprenylation method. Specifically, azlactone compound and isoprene react under the action of zero-valent palladium catalyst and monophosphine ligand, and retroisoprenylation product is obtained. A series of azlactone retroisoprenylation derivatives are obtained by simple and safe steps in the present application.

A genetically engineered microbe capable of producing isoprene from glycerol includes at least a native nucleic acid sequence encoding at least a native enzyme capable of catalyzing one or more steps of a conversion from at least a carbon source to acetyl coenzyme A (A-CoA), at least a first heterologous nucleic acid sequence encoding at least a first enzyme of a mevalonate (MVA) pathway, and at least a second heterologous nucleic acid sequence encoding at least a second enzyme capable of catalyzing at least a terpene-producing chemical reaction, wherein the at least a carbon source includes glycerol.

The present invention is related to fermentative production of isoprenoids, comprising cultivation of a suitable host cell, such as fungal host cell, particularly oleaginous host cell, in an improved two-phase culture system.

The invention relates to a method for synthesizing trans-isopentenyl substituted indolone under the catalysis of transition metal nickel. Specifically, a metal nickel catalyst (Ni (cod) 2) and tricyclohexylphosphine (PCy3) are used as ligands, C3 unsubstituted indolone is used as a nucleophilic reagent to react with isoprene, and a trans-isopentenyl substituted indolone product is obtained. And then taking the product as a reaction raw material, and carrying out nucleophilic substitution reaction on the product and halogenated alkane under an alkaline condition to obtain the 3, 3-disubstituted indolone with divergent functional groups. According to the invention, isoprene is used as a reaction precursor, a trans-isopentenyl substituted indolone product is obtained with high activity and selectivity, a nucleophilic substitution reaction is relayed, and a new strategy is provided for flexibly and conveniently introducing functional groups with different steric hindrances and electrical properties.

Described is a method for the production of isobutene from a carbon source characterized in that it comprises: (a) culturing a microorganism capable of producing 3-methylcrotonic acid from a carbon source in a liquid culture medium, thereby producing 3-methylcrotonic acid so that it accumulates in the liquid culture medium; and (b) enzymatically converting 3-methylcrotonic acid contained in the liquid culture medium obtained in step (a) into isobutene by: (i) incubating a microorganism expressing ap FMN-dependent decarboxylase associated with an FMN prenyl transferase with liquid culture medium containing 3-methylcrotonic acid obtained in step (a); and / or (ii) incubating a FMN-dependent decarboxylase associated with a FMN prenyl transferase with liquid culture medium containing 3-methylcrotonic acid obtained in step (a); thereby producing isobutene; and (c) recovering the produced isobutene.

This invention relates to a method for synthesizing aromatic carbon-10 sulfur-containing compounds from isoprene. Specifically, using disulfide, isoprene, and 2-methyl-1-buten-3-yne as raw materials, aromatic carbon-10 sulfur-containing compounds are constructed under cobalt catalyst and iodine tandem catalysis. This invention has the following advantages: the raw materials are simple and readily available, the synthesis is simple, it is environmentally friendly, the conditions are mild, and it has high atom economy. The compounds obtained from the bulk chemical isoprene have structures similar to natural terpenes and represent an important class of terpenes.

This invention relates to the synthesis of carboxyl-terminated diunsaturated ketones with C=C double bonds at the α,β and γ,δ positions relative to the carbonyl carbon atom, or the β,γ and γ,δ positions. These ketones can be readily obtained from corresponding alkynyl alcohols with terminal carboxyl groups in a few steps. These ketones are important key building blocks for the synthesis of isoprene-like derivatives, especially vitamin E derivatives.

This invention discloses a chiral oxazoline-pyridine-imine cobalt compound, its synthesis method, and its applications. The synthesis method involves the condensation reaction of 2-cyano-6-acetylpyridine and an aniline derivative with p-toluenesulfonic acid to generate a pyridine-imine compound. This compound is then cyclized with different chiral amino alcohols in the presence of zinc trifluoromethanesulfonate to generate chiral oxazoline-pyridine-imine ligands. The reaction of these ligands with anhydrous cobalt chloride successfully prepared four chiral oxazoline-pyridine-imine cobalt compounds. The cobalt catalyst synthesized in this invention possesses different chiral groups, electronic effects, and steric hindrance, and can catalyze the polymerization of isoprene.

The invention provides a preparation method of a natural product indole alkaloid TMC-205, which comprises the following steps: introducing-COCF3 to the 3-site of indole, hydrolyzing-COCF3 to generate TMC-205 or introducing-CHO to the 3-site of indole, and then introducing-CHO to the 3-site to carry out two lines of Pinnick oxidation to generate TMC-205, by establishing an intermediate, the selectivity is high, the side reaction is extremely few, the problem of low yield caused by direct introduction of carboxyl is solved, and the preparation method is suitable for industrial production. According to the present invention, the method can achieve the quantitative and efficient conversion into the carboxyl group, the use of the high toxicity, the high flammability and the expensive reagent in the traditional method is avoided, and in the key step of constructing the core isoprene structure, the 6-bromoindole with the simple structure is innovatively adopted to directly carry out the Heck-dehydration reaction, such that the potential side reaction is effectively reduced, and the cost is reduced; therefore, the product yield is remarkably improved, and the method is suitable for industrial large-scale production.

A genetically engineered microbe capable of producing isoprene from a carbon source and method related thereto include a first nucleic acid sequence encoding a first enzyme, wherein the first enzyme is configured to catalyze one or more steps of a conversion from the carbon source to acetyl coenzyme A (A-CoA), a second nucleic acid sequence encoding a second enzyme of a mevalonate (MVA) pathway, and a heterologous nucleic acid sequence encoding a third enzyme, wherein the third enzyme is configured to catalyzing an isoprene-producing chemical reaction.

The invention is related to a process for synthesizing a sustainable aviation fuel composition. The process comprises providing a reaction mixture comprising a first compound that is at least one of mevalonolactone, mevalonic acid, mevalonate salt, dehydromevalonic acid, dehydromevalonate salt, dehydromevalonolactone or combinations thereof. The process then involves converting the first compound in the reaction mixture to provide a first intermediate comprising isoprene. Then, the isoprene in the first intermediate is reacted in the presence of a first heat transfer agent to provide a second intermediate comprising terpenes. Finally, the second intermediate is allowed to react in the presence of a second heat transfer agent, or alternatively in neat conditions, and optionally in presence of a catalyst to provide the sustainable fuel composition. The sustainable aviation fuel composition made available from the process of the invention is found to comprise monocyclic aromatic hydrocarbons (MAHs) at useful concentration ranges (along with cycloalkanes) while they are substantially devoid of Polycyclic aromatic hydrocarbons (PAHs).

This invention discloses a method for constructing an enzyme cascade reactor using phosphorylated SBA-15 as a carrier to catalyze the synthesis of isoprene from mevalonic acid, belonging to the field of biocatalysis and synthetic biology. This method constructs a co-immobilized phosphatase cascade reactor consisting of mevalonate kinase (MVK), phosphate mevalonate kinase (PMK), mevalonate diphosphate decarboxylase (MVD), isopentenyl pyrophosphate isomerase (IDI), and isoprene synthase (ISPS), achieving highly efficient cascade catalysis from mevalonic acid (MVA) to isoprene. By immobilizing the five enzymes on a phosphorylated mesoporous SBA-15 carrier through hydrogen bonding, the stability, reusability, and catalytic efficiency of the enzymes are significantly improved, solving the problems of easy inactivation and difficulty in recovery of free enzymes. Simultaneously, optimized reaction conditions enable efficient, low-cost, and sustainable preparation of isoprene, suitable for the industrial production of bio-based isoprene.

Disclosed herein are tire tread rubber compositions comprising a specified elastomer component, reinforcing silica filler, carbon black, hydrocarbon plasticizer resin, liquid plasticizer, and a cure package. The elastomer component includes natural rubber, polyisoprene, or a combination thereof; and high cis polybutadiene rubber having a silica-reactive functional group. Use of the disclosed ingredients may result in a tire tread having particular properties, as discussed further herein.

The present invention relates to the enhancement of flumetyl sulforim when it is utilized concomitantly, contemporaneously or in conjunction with Flumetylsulforim-Enhancing compounds, collectively, or typically, Isoprene unit-based compounds or compounds structurally based on 2-methyl-l,3-butadiene units or derived from them, such as, monoterpenoid and derivatives thereof, secondary metabolites originating from isoprene selected from Phenylpropanoids; Monoterpenoids, monoterpenes, flavones, Flavonoids etc., as part of a program to address agricultural and particularly crop plant pathogens, whether in curative, protective, and / or preventative programs. The present invention also relates to methods of increasing the enhancement of flumetylsulforim when it is utilized concomitantly, contemporaneously or in conjunction with Flumetylsulforim- Enhancing compounds collectively, or typically, Isoprene unit-based compounds or compounds structurally based on 2-methyl- 1,3 -butadiene units or derived from them, by adjusting the ratios between the flumetylsulforim and Flumetylsulforim-Enhancing compounds and / or by adjusting the concentration of the compounds in the spray mix from which they are applied.

The present disclosure relates to synthetic biology and, in particular the bioproduction of isoprenoids using heterologous expression of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGR) enzyme(s).

The application relates to an application of a geranylgeranyl pyrophosphate reductase in preparation of tocopherol, wherein a nucleotide sequence coding the geranylgeranyl pyrophosphate reductase is shown as SEQ ID No. 11, and the application comprises the following steps: under the assistance of coenzyme iron-oxidation-reduction protein and iron-oxygen-reduction protein-NADP+ reductase, the geranylgeranyl pyrophosphate reductase catalyzes the reduction of delta-tocotrienol to generate delta-tocopherol. The geranylgeranyl pyrophosphate reductase has the function of reducing the unsaturated isoprene side chain of tocotrienol, can catalyze the reduction of tocotrienol to generate tocopherol, does not need to depend on the geranyl pyrophosphate precursor in the existing tocopherol biosynthesis pathway, significantly improves the tocopherol synthesis efficiency, and provides a new strategy for the biosynthesis of tocopherol and other tocopherols.

This invention discloses a supported composite metal-oxide catalyst, its preparation, and its application in the direct synthesis of high-carbon isoolefins from methanol and ethanol. The catalyst consists of a silicon-based support, metal Cu, and oxides. Based on the total mass of the catalyst, the loading of metal Cu is 0.1–30 wt.%, and the loading of oxides is 0–30 wt.%. The oxides are oxides of elements from Groups IIIB, IVB, and / or IIIA of the periodic table. The catalytic system of this invention is stable under high-temperature reaction conditions. Furthermore, when isobutene is the target product, the conversion rate of ethanol can reach 100%, the yield of isobutene is 41.5%, and the total yield of high-carbon isoolefins reaches 41.5%. When isoprene is the target product, the conversion rate of ethanol can reach 98.2%, the yield of isoprene is 17.9%, and the total yield of high-carbon isoolefins reaches 23.9%.

The invention relates to the technical field of tobacco extracts, in particular to a C13 non-isoprene derivative, an extraction method thereof, a pharmaceutical composition and application of the C13 non-isoprene derivative in preparation of anti-inflammatory drugs or / and anti-tumor drugs. The C13 nonisoprene derivative is obtained by taking tobacco leaves in southern Anhui Province of Anhui Province as a raw material, extracting by using a mixed solvent of ketone and water, extracting by using an ether solvent, sequentially eluting and separating by using silica gel column chromatography, MCI macroporous adsorption resin column chromatography, Sephadex LH-20 gel column chromatography and preparative thin-layer chromatography, and combining TLC (Thin Layer Chromatography) color development and ultraviolet absorption. A cellular level anti-inflammatory experiment shows that the compound has an obvious anti-inflammatory effect on lipopolysaccharide induced inflammation, and has an obvious proliferation inhibition effect on four cancer cells, namely A549, A549-TAX, HT-29 and SNU-398; the compound can be used for preparing anti-inflammatory drugs or / and anti-tumor drugs.

DEPCT6916 / 12 / 2568 This invention relates to a process for preparing 3-methyl-2-butenal (prenal) for... Prepare 3-methyl-2-butane-1-ol(prenol), for the preparation of diprenyl acetate of prenol, including for... Preparation of 3,7-dimethyl-octa-2,6-dienal(citral) where the amount of aldehyde in one reactant stream The current, or more precisely, is kept below the triggering value. Furthermore, this invention also involves... The product stream that can be obtained from prenol, prenol diprenyl acetate of prenol including citral;

To provide improved methods, compositions and host cells for improved prenylation of aromatic substrates or production of downstream metabolites thereof in host cells.SOLUTION: Provided herein are methods and compositions for producing cannabinoids and other metabolites in a host cell.SELECTED DRAWING: Figure 1

The invention provides a synthesis method of an (E)-2-methylpentyl-1, 3-diene compound, which comprises the following steps: by taking a compound as shown in a formula (3) as a raw material, reacting in an organic solvent under the action of triethylamine hydrobromide (Et3N.HBr) to generate the (E)-2-methylpentyl-1, 3-diene compound as shown in a formula (4). The method can be carried out under mild conditions, and the problems that traditional metal catalysis or strong acid catalysis is poor in compatibility with sensitive functional groups, harsh in reaction condition, serious in environmental pollution and the like are solved; meanwhile, the substrate is high in universality and can be compatible with electron-donating and electron-withdrawing substituted benzene ring substrates and various heteroaromatic ring substrates; besides, post-treatment of the product is simple and convenient, a high-purity product can be obtained through conventional column chromatography, and a brand new scheme is provided for green synthesis of isoprene fine chemicals.