The present invention is related to an alcoholic formulation comprising a mixture of alkaloids, specifically
piperine, piperettine, trichostaquine, piperoleins, other alkamides, and / or other alkaloids, as well as terpenoids, phenolics,
prenol lipids, and flavonoids. The formulation is particularly rich in piperines, which are found in greater proportion compared to the other compounds. This unique composition exhibits anti-tumor activity
in vitro, reducing tumors generated by
orthotopic transplantation of tumors in animal models. Furthermore, it modulates the immune response by reducing the frequency of intratumoral immunosuppressive cells and increasing the frequency of cytotoxic T lymphocytes, thereby promoting tumor destruction and controlling
metastasis.