A method for the selective hydrogenation of prenyl aldehyde to synthesize prenol

Abstract

The invention discloses a method for synthesizing prenol employing selective hydrogenation of 3-methylcrotonaldehyde. The method comprises the following steps: feeding, nitrogen and hydrogen substitution, hydrogenation reaction, and separation. The used raw materials comprise 1 part of 3-methylcrotonaldehyde, 0.1-10 parts of water and 0.02-0.2 part of a catalyst; and the used catalyst is a water-soluble complex which is formed by a water-soluble salt of the group VIII metal and a water-soluble ligand. The 3-methylcrotonaldehyde conversion ratio and the selectivity of prenol of the synthetic reaction are high; a water phase of the catalyst can be applied repeatedly for over 20 times; the unit consumption of the catalyst is low; the production cost is greatly reduced; and the method is suitable for industrial production.

Description

technical field

[0001] The invention relates to a method for synthesizing prenol as an intermediate of medicine, fragrance and pesticide, in particular to a method for selectively hydrogenating prenol to prenol. Background technique

[0002] Isopentenol (3-methyl-2-butenol), is an important medicine, fragrance and pesticide intermediate, which can be used to produce citral, isophytol, DV methyl chrysanthemum, vitamin E, vitamin A. Carotenoid intermediates, etc., can also be used in other organic synthesis.

[0003] The synthetic method of isopentenol mainly contains following several kinds at present:

[0004] 1. Isobutene method: Patent US4028424 describes the preparation of prenol by Prince reaction with isobutene and formaldehyde as raw materials, but the reaction selectivity is poor, the selectivity of prenol is about 5%, and 80 ~90% 3-methyl-3-butenol;

[0005] Patent WO2008037693 describes that 3-methyl-3-butenol is prepared by condensation reaction using isobutene ...

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