Composition combining DNA damage causing compounds with DNA damage repair inhibitors, and preparation method and application of composition

A DNA damage and inhibitor technology, applied in the field of preparation of drugs for the treatment of echinococcosis, can solve the problems of single action target, large toxic and side effects, poor therapeutic effect, etc., and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2020-09-29
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention provides a composition, preparation method and application of a DNA damage-causing compound combined with a DNA damage repair inhibitor, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the problem that existing drugs for the treatment of echinococcosis have a single target. , Poor therapeutic effect and serious side effects

Method used

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  • Composition combining DNA damage causing compounds with DNA damage repair inhibitors, and preparation method and application of composition
  • Composition combining DNA damage causing compounds with DNA damage repair inhibitors, and preparation method and application of composition
  • Composition combining DNA damage causing compounds with DNA damage repair inhibitors, and preparation method and application of composition

Examples

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Effect test

Embodiment 1

[0030] Embodiment 1: The composition of the DNA damage-causing compound combined with a DNA damage repair inhibitor, including a DNA damage-causing compound and a DNA damage repair inhibitor, wherein the DNA damage-causing compound is dehydrohaeline, dehydrohaeline derivatives, At least one of doxorubicin, actinomycin D, daunomezine, etoposide and teniposide, and the DNA damage repair inhibitor is at least one of RAD51 inhibitors and BRCA1 inhibitors.

[0031] The composition of the present invention that causes DNA damage combined with a DNA damage repair inhibitor uses the DNA damage compound and the DNA damage repair inhibitor drug in combination, while the DNA damage compound resists the DNA damage of cystic echinococcosis, the DNA damage repair inhibitor Blocking the DNA damage repair of anti-cystic echinococcosis, multiple targets play an anti-echinococcosis effect, and improve the therapeutic effect of anti-echinococcosis. Single point, poor therapeutic effect and serio...

Embodiment 2

[0032] Example 2: As an optimization of the above examples, the RAD51 inhibitors are RAD51 inhibitor RI-1, RAD51 inhibitor RI-2, RAD51 inhibitor Amuvatinib MP470, RAD51 inhibitor B02, RAD51 inhibitor IBR2 and RAD51 inhibitor RAD51- More than one of IN-2.

[0033]The RAD51 inhibitor RI-1 is RAD51 Inhibitor RI-1, the RAD51 inhibitor RI-2 is RAD51 Inhibitor RI-2, the RAD51 inhibitor Amuvatinib MP470 is RAD51 Inhibitor Amuvatinib MP470, and the RAD51 inhibitor B02 is RAD51 Inhibitor B02, The RAD51 inhibitor IBR2 is RAD51 Inhibitor IBR2, and the RAD51 inhibitor RAD51-IN-2 is RAD51 Inhibitor RAD51-IN-2.

Embodiment 3

[0034] Example 3: As an optimization of the above examples, the BRCA1 inhibitor is BRCA1 inhibitor BRCA1-IN-1.

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Abstract

The invention relates to the technical field of preparation of medicine for treating echinococcosis, in particular to a composition combining DNA damage causing compounds with DNA damage repair inhibitors, and a preparation method and application of the composition. The composition comprises the DNA damage causing compounds and the DNA damage repair inhibitors. The DNA damage causing compounds areone or more kind of materials of harmine, harmine derivatives, adriamycin, dactinomycin, daunorubicin, etoposide and teniposide; and the DNA damage repair inhibitors are one or more kind of materialsof an RAD51 inhibitor and a BRCA1 inhibitor. Through combined use of the DNA damage causing compounds and the DNA damage repair inhibitors, the composition provided by the invention is used for treating the echinococcosis; the effect of realizing the damage to worm body DNA by the DNA damage causing compounds and realizing the inhibition on the DNA damage repair by the DNA damage repair inhibitors at the same time can be achieved; the worm body DNA damage repair process is completely blocked; finally, the worm body apoptosis is caused; the anti-echinococcosis effect is achieved; and the anti-echinococcosis treatment effect is improved.

Description

technical field [0001] The invention relates to the technical field of preparing medicines for treating echinococcosis, and relates to a composition, a preparation method and an application of a DNA damage-causing compound combined with a DNA damage repair inhibitor. Background technique [0002] Cystic Echinococcosis (CE), also known as granulosus echinococcosis, is a zoonotic parasitic disease with worldwide distribution, which seriously threatens the development of public health and animal husbandry, causing about 3 billion economic loss. In my country, it is mainly distributed in Xinjiang, Qinghai, Tibet and other western animal husbandry areas, and there are about 160,000 patients with the disease, ranking first in the world. At present, the treatment methods for echinococcosis include surgical treatment, drug treatment, immunoprevention and radiotherapy, etc. Surgical treatment has always been the first choice, but due to the complexity of the disease, the postoperati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/437A61K31/704A61K38/12A61K31/7048A61P33/10
CPCA61K45/06A61K31/437A61K31/704A61K38/12A61K31/7048A61P33/10
Inventor 王建华温浩赵军巩月红高旖卢帅文丽梅陈蓓耿伟高惠静吕国栋
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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