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A kind of Lycium barbarum polysaccharide lrp3-s1, its preparation method and its use

A technology of LRP3-S1 and wolfberry black fruit, which is applied in the field of polysaccharides

Active Publication Date: 2021-11-26
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As the main component of black fruit wolfberry, polysaccharides have been reported to have anti-fatigue, immune regulation, anti-inflammatory, hypoglycemic, and anti-oxidative effects, but there are few reports on anti-tumor

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  • A kind of Lycium barbarum polysaccharide lrp3-s1, its preparation method and its use
  • A kind of Lycium barbarum polysaccharide lrp3-s1, its preparation method and its use
  • A kind of Lycium barbarum polysaccharide lrp3-s1, its preparation method and its use

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preparation Embodiment 1

[0027] Preparation Example 1 Extraction, separation, purification and structural characterization of Lycium barbarum polysaccharide LRP3-S1

[0028] (1) Extraction and separation of polysaccharides

[0029] Soak the black wolfberry fruit in industrial ethanol for one week, air-dry the black wolfberry after soaking, and then extract it by boiling water extraction, and detect the sugar content of the extract by the sulfuric acid-phenol method until the sugar reaction is not obvious. The extracts were combined, concentrated to a small volume, and centrifuged to remove the precipitate. The supernatant was dialyzed against countercurrent water for two days. The dialyzed internal solution was alcohol-precipitated with ethanol with a volume fraction of 95%, and the volume ratio of the extract to ethanol was 1:5 (v / v), and stood overnight. The excess ethanol in the upper layer was discarded, and the precipitate was centrifuged, washed alternately with ethanol and acetone three times...

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Abstract

The present invention provides a preparation method of Lycium barbarum polysaccharide LRP3‑S1 obtained from Lycium barbarum fruit, the use of the polysaccharide to inhibit the proliferation and invasion of pancreatic cancer cells, and the use in the preparation of drugs for preventing and / or treating pancreatic cancer . The homogeneous polysaccharide was obtained by water extraction and alcohol precipitation method and chromatographic column separation and purification, and the RG‑I structure of the polysaccharide was identified by chemical and physical methods. In vitro experiments have proved that the polysaccharide can inhibit the proliferation of pancreatic cancer cells and weaken their invasion ability. Therefore, the polysaccharide has a potential therapeutic effect on pancreatic cancer, and may become a kind of carbohydrate drug against pancreatic cancer.

Description

technical field [0001] The present invention relates to the use of a polysaccharide, specifically relates to a kind of RG-I type pectin extracted from Lycium ruthenicum Murr, and also provides its preparation method and its role in the treatment of pancreatic cancer The application in the preparation of the medicine for preventing and / or treating pancreatic cancer. Background technique [0002] Pancreatic cancer is one of the most malignant solid tumors with the worst prognosis and the lowest five-year survival rate. At the same time, pancreatic cancer has a high aggressiveness, and usually metastasizes in the early stage of the cancer, invading the stroma, blood vessels and their peripheral tissues, which greatly increases the mortality rate. Therefore, it has become one of the major diseases that people are paying close attention to at present. [0003] Lycium barbarum black fruit is a unique medicinal and edible plant in Northwest China. It has the functions of nourishi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/06A61K31/732A61P35/00
CPCA61K31/732A61P35/00C08B37/0045C08B37/0048
Inventor 丁侃陈霞张世海何菲
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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