Fungicide imazalil ionic liquid, preparation method and application thereof
A technology of ionic liquid and imazalil, applied in the direction of fungicides, botany equipment and methods, applications, etc., can solve the problems of limited development speed, high cost, and long drug development cycle of new fungicides
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Embodiment 1
[0032] Embodiment one The synthesis of imazalil ionic liquid
[0033] Weigh 0.297g of the original drug imazalil into a 50mL three-neck bottle, add 20mL of methanol to fully dissolve imazalil; add relevant anionic ligands (acetic acid, nonanoic acid, oleic acid, salicylic acid, benzoic acid) , The reaction was stirred at 60-70°C, and the reaction was followed by thin chromatography separation until the reaction was complete. The reaction compound is removed by a rotary evaporator to remove methanol, and the related imazalil ionic liquid can be obtained.
[0034] Six kinds of anionic ligands mentioned above were selected, and six kinds of imazalil ionic ligands were synthesized by acid-base neutralization reaction. Among them, number 1 is imazalil; number 2 is imazalil-acetic acid ionic liquid; number 3 is imazalil-nonanoic acid ionic liquid; number 4 is imazalil-oleic acid ionic liquid; number 5 is imazalil - Benzoic acid ionic liquid; number 6 is imazalil-salicylic acid ion...
Embodiment 2
[0039] Embodiment two characterization of imazalil ionic liquid
[0040] Take an appropriate amount of the imazalil ionic liquid prepared in Example 1 and put it in an NMR tube, add 600 μL of deuterated chloroform, and use a nuclear magnetic resonance instrument Bruker Avance DPX 300 MHz to carry out the characterization of the proton nuclear magnetic resonance spectrum, and analyze the structural characteristics of the imazalil ionic liquid .
[0041] The obtained imazalil ionic liquid was characterized by proton nuclear magnetic resonance spectrum by nuclear magnetic resonance instrument. From the data of the hydrogen spectrogram in Table 2, it can be seen that the active hydrogen of the carboxyl group located in the high field in all paired ions disappeared, and the imazalil in the synthetic product was -Acetic acid ionic liquid, imazalil-nonanoic acid ionic liquid and imazalil-oleic acid ionic liquid N-CH-N hydrogen spectrum shift on the imidazole ring moved to the high fi...
Embodiment 3
[0045] Example 3: Determination of Sensitivity of Pepper Anthracnose Pathogenic Bacteria to Imazalil
[0046] 1. Preparation of culture medium
[0047] PDA medium: Potato dextrose agar medium without antibiotics purchased from Suleibao Company, weighed 46g, dissolved in 1L ddH2O, autoclaved at 121°C for 20min, and set aside.
[0048] 2. Preparation of drug-containing medium
[0049] Completely dissolve imazalil with a mixed solution of methanol and water to prepare imazalil mother solution with a concentration of 5.0 mg / mL. To the 200mL PDA medium cooled to about 55°C, add the corresponding volume of 5mg / L imazalil, mix well, and prepare to contain 0.5mg / L, 1.0mg / L, 2.0mg / L, 4.0mg / L , 8.0mg / L and 16.0mg / L imazalil PDA plates.
[0050] 3. Determination of sensitivity of pepper anthracnose pathogen to imazalil
[0051] Sensitivity assays were performed using the growth rate method. The test strains HHBY48 (C.acutatum), YYGXZ07 (C.brevisporum), HBLF01 (C.capsici), CZHP03 (C....
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