Sodium hyaluronate eye drops containing 0.01% of atropine and preparation method of sodium hyaluronate eye drops

Abstract

The invention discloses sodium hyaluronate eye drops containing 0.01% of atropine. The eye drops comprise sodium hyaluronate, atropine, sodium hydroxide, hydrogen chloride, sodium chloride and water for injection. The mass concentration of sodium hyaluronate is 0.1-10 g/L, the mass concentration of atropine is 0.1 g/L, sodium hydroxide and hydrogen chloride are pH regulators, and sodium chloride is an osmotic pressure regulator. The eye drops contain no traditional Chinese medicinal components, bacteriostatic agent, preservative, cosolvent, thicken agent, complexing agent or the like, the components are simple and are normal substances of human bodies except for atropine, so that corneal damage caused by damage of the microenvironment on the surfaces of eyeballs is avoid, harm to the humanbodies and growth and development due to long-term excessive use of components such as traditional Chinese medicine is also avoided, and the incidence of allergic reaction is effectively reduced. Inaddition, the eye drops have pH and osmotic pressure adjusted, use comfort is improved, small-dose independent packages are also produced based on aseptic filling and a hot pressing sterilization process, and biological safety of the product is ensured.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a sodium hyaluronate eye drop containing 0.01% atropine and a preparation method thereof. Background technique [0002] Myopia is a kind of refractive error, which refers to a kind of eye disease that reduces vision, sees distant objects blurred, and sees near objects clearly. After wearing glasses for correction, distance vision can be improved. With the changes in people's lifestyle, eating habits and living environment, the number of myopia patients is increasing year by year, and the age of onset tends to be younger, especially in school-age children. At present, my country has become a big country with myopia, and the number of people suffering from myopia ranks first in the world, and the high incidence of myopia among young people and the younger age have become public health problems that have attracted much attention. In 2016, Peking Univ...

AI Technical Summary

Problems solved by technology

In addition, sodium hyaluronate eye drops have no systemic effects other than basic local physical effects (sur