Device and method for realizing passive fusion of micro-droplets

A micro-droplet and droplet technology, applied to laboratory containers, chemical instruments and methods, laboratory utensils, etc., can solve the problems of complex micro-channel structures and increased difficulty of micro-channels

Active Publication Date: 2020-10-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Compared with active fusion, the flow control system of passive fusion is simpler and has less interference with the characteristics of the droplet itself, but the microchannel structure is more complicated, which increases the difficulty of microchannel fabrication

Method used

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  • Device and method for realizing passive fusion of micro-droplets
  • Device and method for realizing passive fusion of micro-droplets
  • Device and method for realizing passive fusion of micro-droplets

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Experimental program
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Embodiment

[0053] In the device of the present embodiment, the width of the first microchannel 6 is 100 μm, the width of the second microchannel 7 and the third microchannel 8 is 30 μm, and between the second microchannel branch 7 and the first microchannel branch 6 The included angle and the included angle α between the third microchannel branch 8 and the first microchannel branch 6 are both 90°. In this embodiment, the continuous phase fluid c injected into the first microchannel branch 6 by the first syringe pump 2 is deionized water, and the first dispersed phase fluid c injected into the second microchannel branch 7 by the second syringe pump 3 Both d1 and the second dispersed phase fluid d2 injected into the third microchannel branch 8 by the third syringe pump 1 are mineral oils, wherein a dyeing agent is added to the second dispersed phase fluid d2 to make the first dispersed phase fluid d1 It is easier to distinguish between d2 and the second dispersed phase fluid. The rest of ...

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Abstract

The invention discloses a device and a method for realizing passive fusion of micro-droplets. The inlet end of a micro-channel main path is respectively communicated with a first micro-channel branchpath, a second micro-channel branch path and a third micro-channel branch path; the axis of the first micro-channel branch path is the same as the axis of the micro-channel main path, and the includedangle between the second micro-channel branch path and the first micro-channel branch path is the same as the included angle between the third micro-channel branch path and the first micro-channel branch; and a first injection pump injects a continuous phase fluid into the first micro-channel branch path, a second injection pump injects a first dispersed phase fluid into the second micro-channelbranch path, and a third injection pump injects a second dispersed phase fluid into the third micro-channel branch path. Under the condition that the device does not need to be provided with a complexmicro-channel structure, efficient fusion between micro-droplets can be achieved. Meanwhile, the plurality of groups of injection pumps and micro-channels can be arranged as required, so that the mutual fusion of a plurality of micro-droplets is realized.

Description

technical field [0001] The invention belongs to the technical field of droplet fusion, and in particular relates to a device and method for realizing passive fusion of micro-droplets. Background technique [0002] Droplet-Based Microfluidics is an important branch of microfluidic chip technology in recent years. Droplet microfluidic technology is a new technology for manipulating tiny volume droplets, that is, the microfluidic chip uses the interaction of two or more immiscible liquids to generate highly monodisperse nanoliter to femtoliter droplet. In the application of droplet microfluidics technology, the controllable fusion of droplets is an important means of mixing between different reagents or samples, and is widely used in the fields of particle synthesis, biochemical reactions, and drug screening. [0003] Currently, droplet fusion is mainly divided into two categories: active fusion and passive fusion. The active fusion of droplets refers to the effect of extern...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/50273
Inventor 钱锦远李晓娟金志江
Owner ZHEJIANG UNIV
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