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Compositions and methods for broad-spectrum antiviral therapy

An anti-virus and virus technology, applied in the direction of anti-viral agents, active ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve the problems of restricting wide application, unfavorable pharmacokinetics, narrow therapeutic window, etc.

Pending Publication Date: 2020-11-03
VERSITECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a number of drawbacks, such as unfavorable pharmacokinetics and narrow therapeutic window, limit its widespread use in clinical settings [9]

Method used

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  • Compositions and methods for broad-spectrum antiviral therapy
  • Compositions and methods for broad-spectrum antiviral therapy
  • Compositions and methods for broad-spectrum antiviral therapy

Examples

Experimental program
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Embodiment

[0144] Cells and viruses: human embryonic kidney (HEK293T) cells, human lung cancer (A549) cells, human liver cancer (Huh7) cells, human rhabdomyosarcoma (RD) cells, human epithelial type 2 (HEp-2) cells, human lung adenocarcinoma ( Calu-3) cells, human leukemia (THP-1) monocytes, Madin-Darby canine kidney (MDCK) cells, African green monkey kidney (Vero) cells, and Vero-E6 cells were obtained from ATCC, and according to the supplier / Manufacturer's recommendations are kept in the medium. Human peripheral blood mononuclear cell-derived macrophages (MDMs) were isolated from healthy adult blood samples collected from the Hong Kong Red Cross Blood Transfusion Service according to an institutional review board-approved protocol at The University of Hong Kong. Monocyte preparation and differentiation were performed according to established protocols, as previously described by the inventors [45]. All cell lines were incubated at 37 °C in 5% CO 2 cultivated in. All cell lines used...

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Abstract

AM580 and structurally related compounds have been found to be useful in treating infection by a wide range of RNA and DNA viruses, and also in reducing associated inflammation. This activity is independent of RAR-alpha signaling, and is not a result of activation of the hosts innate immune response. Broad antiviral activity of AM580 and structurally related compounds is a due to modulation of lipogenesis so as to correct disregulation of this pathway in virus-infected cells, via inhibition of nSREPBP.

Description

[0001] This application claims the benefit of U.S. Provisional Application No. 62 / 573933, filed October 18, 2017. These and all other referenced external materials are hereby incorporated by reference in their entirety. To the extent that a definition or use of a term in a reference incorporated by reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein controls. technical field [0002] The field of the invention is antiviral therapy, in particular antiviral therapy using small molecules. Background technique [0003] The Background Description includes information useful for understanding the present invention. No admission is made that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication referenced, either explicitly or implicitly, is prior art. [0004] Severe Acute Respiratory Syndrome (SARS), Pandemic Influenza A (H1N1), Mid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61K31/07A61K31/192A61K45/06A61P31/12
CPCA61P31/12A61K31/196A61K31/192
Inventor 袁硕峰陈福和朱轩刘耀南袁国勇
Owner VERSITECH LTD
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